Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0365 | 0.1648 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0093 | 0.0888 | 0.0859 |
Plasmodium falciparum | p25-alpha family protein, putative | 0.0026 | 0.0034 | 0.002 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0032 | 0.0112 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0165 | 0.1801 | 0.1774 |
Echinococcus multilocularis | tubulin polymerization promoting protein family | 0.0026 | 0.0034 | 0.0009 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.2212 | 1 |
Plasmodium vivax | p25-alpha family protein, putative | 0.0026 | 0.0034 | 0.002 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.0953 | 0.4305 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0101 | 0.0994 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.0994 | 1 |
Echinococcus granulosus | tubulin polymerization promoting protein family | 0.0026 | 0.0034 | 0.0009 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.0888 | 0.4015 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.0888 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0365 | 0.1648 |
Trypanosoma brucei | p25-alpha, putative | 0.0026 | 0.0034 | 0.0023 |
Echinococcus multilocularis | tubulin polymerization promoting protein family | 0.0026 | 0.0034 | 0.0009 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0093 | 0.0888 | 0.3927 |
Onchocerca volvulus | TPPP family protein homolog | 0.0807 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.0365 | 0.1526 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0061 | 0.0476 | 0.4617 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1136 | 0.5134 |
Echinococcus multilocularis | tubulin polymerization promoting protein family | 0.0026 | 0.0034 | 0.0009 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0052 | 0.0365 | 0.0334 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0101 | 0.0994 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0165 | 0.1801 | 0.1774 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.0034 | 0.002 |
Giardia lamblia | Hypothetical protein | 0.0026 | 0.0034 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0365 | 0.0334 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0093 | 0.0888 | 1 |
Entamoeba histolytica | Flap nuclease, putative | 0.0026 | 0.0032 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0034 | 0.0023 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0098 | 0.0953 | 0.0924 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0098 | 0.0953 | 0.4222 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0365 | 0.1648 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0165 | 0.1801 | 0.1774 |
Echinococcus granulosus | tubulin polymerization promoting protein family | 0.0026 | 0.0034 | 0.0009 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.1199 | 0.1171 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0101 | 0.0994 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0098 | 0.0953 | 0.4222 |
Echinococcus granulosus | tubulin polymerization promoting protein family | 0.0026 | 0.0034 | 0.0009 |
Schistosoma mansoni | p25-alpha domain containing protein | 0.0026 | 0.0034 | 0.0153 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0098 | 0.0953 | 0.0924 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.1199 | 0.1171 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.0365 | 0.1526 |
Echinococcus granulosus | geminin | 0.0197 | 0.2212 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.1199 | 0.1171 |
Schistosoma mansoni | P25 alpha-related | 0.0026 | 0.0034 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 0.6106 | 0.6094 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0031 | 0.0094 | 0.0723 |
Echinococcus multilocularis | geminin | 0.0197 | 0.2212 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0365 | 0.1648 |
Loa Loa (eye worm) | p25-alpha family protein | 0.0807 | 1 | 1 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.0888 | 1 |
Echinococcus granulosus | tubulin polymerization promoting protein family | 0.0026 | 0.0034 | 0.0009 |
Brugia malayi | hypothetical protein | 0.0502 | 0.6106 | 0.6094 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0101 | 0.0994 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.0953 | 0.4305 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0098 | 0.0953 | 0.4222 |
Echinococcus multilocularis | tubulin polymerization promoting protein family | 0.0026 | 0.0034 | 0.0009 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0052 | 0.0365 | 0.0334 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0034 | 0.0153 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.003 | 0.0082 | 0.0589 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0093 | 0.0888 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0093 | 0.0888 | 0.0859 |
Treponema pallidum | ATP-binding protein (ylxH-1) | 0.0434 | 0.5244 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.0888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1136 | 0.1108 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0034 | 0.0023 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0098 | 0.0953 | 0.4222 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.1801 | 0.1774 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0052 | 0.0365 | 0.0334 |
Trypanosoma cruzi | p25-alpha, putative | 0.0026 | 0.0034 | 0.0023 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0093 | 0.0888 | 0.3927 |
Toxoplasma gondii | p25-alpha family protein | 0.0026 | 0.0034 | 0.002 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0101 | 0.0994 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0052 | 0.0365 | 0.1526 |
Toxoplasma gondii | p25-alpha family protein | 0.0026 | 0.0034 | 0.002 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.0365 | 0.1526 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.0953 | 0.4305 |
Trypanosoma cruzi | p25-alpha, putative | 0.0026 | 0.0034 | 0.0023 |
Echinococcus multilocularis | GPCR, family 2 | 0.0052 | 0.0365 | 0.1526 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.0994 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.2212 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.0365 | 0.1526 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0113 | 0.1136 | 0.1108 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 1000 uM | Cytotoxicity against Homo sapiens (human) K562 cells assessed as growth inhibition after 48 hr by MTT assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.