Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pseudomonas aeruginosa | Beta-lactamase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | ribonuclease Z | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0368 | 1 | 1 |
Leishmania major | metallo-beta-lactamase family protein-like protein | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | metallo-beta-lactamase domain-containing protein | 0.0019 | 0 | 0.5 |
Leishmania major | cleavage and polyadenylation specificity factor, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | metallo-beta-lactamase-like protein, putative | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | cytosolic glyoxalase II | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Treponema pallidum | ribonuclease Z | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | hydroxyacylglutathione hydrolase, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | Hydroxyacylglutathione hydrolase, mitochondrial homolog | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0368 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Trypanosoma cruzi | glyoxalase II | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0368 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0368 | 1 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | glyoxalase II | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | glyoxalase II, GloB | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0 | 0.5 |
Giardia lamblia | Metallo-beta-lactamase superfamily protein | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | metallo-beta-lactamase-like protein, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0368 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0368 | 1 | 1 |
Mycobacterium ulcerans | beta lactamase-like protein | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0 | 0.5 |
Mycobacterium leprae | POSSIBLE HYDROLASE | 0.0019 | 0 | 0.5 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.0019 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | Putative hydrolase PNKD | 0.0019 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0368 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | metallo-beta-lactamase superfamily, putative | 0.0019 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | metallo-beta-lactamase superfamily hydrolase | 0.0019 | 0 | 0.5 |
Plasmodium vivax | unspecified product | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | metallo-beta-lactamase-like protein, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | glyoxalase II | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | glyoxalase II | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0368 | 1 | 1 |
Leishmania major | hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0368 | 1 | 1 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | cleavage and polyadenylation specificity factor subunit, putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0368 | 1 | 1 |
Plasmodium vivax | hydroxyacyl glutathione hydrolase, putative | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Beta lactamase like protein | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0019 | 0 | 0.5 |
Mycobacterium leprae | Beta-lactamase-like protein | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0019 | 0 | 0.5 |
Leishmania major | metallo-beta-lactamase family-like protein | 0.0019 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | metallo-beta-lactamase superfamily, putative | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | hydroxyacylglutathione hydrolase | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | Zn-dependent glyoxylase | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 | Inhibition of Pseudomonas aeruginosa IMP1 metallo-beta-lactamase | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.