Detailed view for PVX_221290

Basic information

TDR Targets ID: 322157
Plasmodium vivax, unspecified product
Source Database / ID:  PlasmoDB 

pI: 5.5525 | Length (AA): 289 | MW (Da): 32960 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00753   Metallo-beta-lactamase superfamily
PF16661   Metallo-beta-lactamase superfamily domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  

Metabolic Pathways

mRNA surveillance pathway (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 288 2i7t (A) 10 235 48.00 0.00000037 1 1.13578 0.55
16 139 1e5d (A) 34 155 16.00 0.27 0.32 0.630566 -0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127285)

Species Accession Gene Product
Arabidopsis thaliana AT1G61010   cleavage and polyadenylation specificity factor subunit 73-I
Babesia bovis BBOV_IV001630   cleavage and polyadenylation specifity factor
Brugia malayi Bm1_34605   cpsf3-prov protein
Candida albicans CaO19.5486   subunit of polyadenylation factor I
Candida albicans CaO19.12941   subunit of polyadenylation factor I
Caenorhabditis elegans CELE_Y67H2A.1   Protein CPSF-3
Cryptosporidium hominis Chro.80059   cleavage and polyadenylation specifity factor protein
Cryptosporidium parvum cgd8_460   cleavage and polyadenylation specifity factor protein, CPSF metallobeta-lactamase
Dictyostelium discoideum DDB_G0274799   DNA repair metallo-beta-lactamase domain-containing protein
Drosophila melanogaster Dmel_CG7698   Cleavage and polyadenylation specificity factor 73
Echinococcus granulosus EgrG_001021200   Cleavage and polyadenylation specificity factor
Entamoeba histolytica EHI_136170   cleavage and polyadenylation specificity factor 73 kDa subunit, putative
Echinococcus multilocularis EmuJ_001021200   Cleavage and polyadenylation specificity factor
Giardia lamblia GL50803_4498   Cleavage and polyadenylation specificity factor, 73 kDa subunit
Homo sapiens ENSG00000119203   cleavage and polyadenylation specific factor 3, 73kDa
Leishmania braziliensis LbrM.20.3010   cleavage and polyadenylation specificity factor, putative
Leishmania donovani LdBPK_343210.1   cleavage and polyadenylation specificity factor, putative
Leishmania infantum LinJ.34.3210   cleavage and polyadenylation specificity factor, putative
Leishmania major LmjF.34.3430   cleavage and polyadenylation specificity factor, putative
Leishmania mexicana LmxM.33.3430   cleavage and polyadenylation specificity factor, putative
Loa Loa (eye worm) LOAG_06840   cpsf3-prov protein
Mus musculus ENSMUSG00000054309   cleavage and polyadenylation specificity factor 3
Neospora caninum NCLIV_014990   hypothetical protein
Oryza sativa 4334816   Os03g0852900
Plasmodium berghei PBANKA_1302400   cleavage and polyadenylation specificity factor subunit 3, putative
Plasmodium falciparum PF3D7_1438500   cleavage and polyadenylation specificity factor subunit 3, putative
Plasmodium knowlesi PKNH_1243900   cleavage and polyadenylation specificity factor subunit 3, putative
Plasmodium vivax PVX_221290   unspecified product
Plasmodium vivax PVX_118570   cleavage and polyadenylation specificity factor, putative
Plasmodium vivax PVX_209290   unspecified product
Plasmodium yoelii PY00665   cleavage and polyadenylation specificity factor, 73 kDa subunit
Saccharomyces cerevisiae YLR277C   Ysh1p
Schistosoma japonicum Sjp_0310280   Cleavage and polyadenylation specificity factor subunit 3, putative
Schistosoma japonicum Sjp_0011280   Cleavage and polyadenylation specificity factor subunit 3, putative
Schistosoma mansoni Smp_084380   cleavage and polyadenylation specificity factor-related
Schmidtea mediterranea mk4.015559.00  
Schmidtea mediterranea mk4.000158.08  
Schmidtea mediterranea mk4.030240.00  
Schmidtea mediterranea mk4.005289.01  
Schmidtea mediterranea mk4.000158.07   Cleavage and polyadenylation specificity factor subunit 3
Trypanosoma brucei gambiense Tbg972.4.1170   cleavage and polyadenylation specificity factor subunit, putative
Trypanosoma brucei Tb927.4.1340   cleavage and polyadenylation specificity factor subunit, putative
Trypanosoma congolense TcIL3000_4_840   cleavage and polyadenylation specificity factor subunit, putative
Trypanosoma cruzi TcCLB.508693.10   cleavage and polyadenylation specificity factor, putative
Toxoplasma gondii TGME49_285200   cleavage and polyadenylation specifity factor protein
Theileria parva TP03_0560   cleavage and polyadenylation specificity factor protein, putative
Theileria parva TP03_0561   hypothetical protein
Trichomonas vaginalis TVAG_437970   cleavage and polyadenylation specificity factor, putative

Essentiality

PVX_221290 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.1340 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.4.1340 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.1340 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.1340 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y67H2A.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y67H2A.1 Caenorhabditis elegans larval arrest wormbase
YLR277C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1302400 Plasmodium berghei Essential plasmo
TGME49_285200 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0156 1 0.5
0.0249 0.3365 1
0.0153 1 0.5
0.0367 0.531 1
0.0079 0.301 1
0.0051 0.5023 0.5
0.0183 1 1
0.0085 0.271 1
0.0134 0.3422 1
0.0153 1 0.5
0.0259 0.336 1
0.0019 0.5 0.5
0.0282 0.3876 1
0.024 0.347 0.5
0.0333 0.487 1
0.03 0.9089 1
0.0098 0.5 0.5
0.0284 0.6112 1
0.0208 0.4509 1
0.0101 0.5 0.5
0.0033 0.5 0.5
0.0286 1 0.5
0.0304 0.3722 1
0.0307 0.4131 1
0.0215 0.5175 0.5
0.0101 0.5 0.5
0.0031 0.5 0.5
0.0151 0.5 0.5
0.0139 0.3313 1
0.032 0.4025 0.5
0.0068 0.616 0.5
0.03 0.9089 1
0.0224 1 0.5
0.0138 0.8072 0.5
0.0065 0.5 0.5
0.0141 0.5 0.5
0.0173 0.5058 1
0.0304 0.3722 1
0.0115 1 0.5
0.0161 1 1
0.0088 0.4106 0.5
0.035 0.2506 1
0.0263 0.5703 1
0.0404 0.2792 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PVX_221290 (Plasmodium vivax), unspecified product
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