Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Zea mays | Protoporphyrinogen IX oxidase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0105 | 0.4794 | 0.7278 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0105 | 0.4794 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0105 | 0.4794 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0025 | 0 | 0.5 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0105 | 0.4794 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0135 | 0.6587 | 0.7764 |
Echinococcus multilocularis | dual specificity | 0.0105 | 0.4794 | 0.4794 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0135 | 0.6587 | 0.6587 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0135 | 0.6587 | 0.6587 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0105 | 0.4794 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0136 | 0.6642 | 1 |
Echinococcus multilocularis | dual specificity | 0.0105 | 0.4794 | 0.4794 |
Echinococcus granulosus | dual specificity | 0.0105 | 0.4794 | 0.565 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0105 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | haspin protein kinase | 0.0135 | 0.6587 | 0.9918 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0192 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.6587 | 0.6587 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0167 | 0.8485 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0192 | 1 | 1 |
Brugia malayi | GSG2 | 0.0135 | 0.6587 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0105 | 0.4794 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0135 | 0.6587 | 0.7764 |
Brugia malayi | hypothetical protein | 0.0135 | 0.6587 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0135 | 0.6587 | 0.9918 |
Echinococcus multilocularis | dual specificity | 0.0105 | 0.4794 | 0.4794 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0135 | 0.6587 | 0.7764 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0105 | 0.4794 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0105 | 0.4794 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0167 | 0.8485 | 1 |
Echinococcus granulosus | dual specificity | 0.0105 | 0.4794 | 0.565 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0105 | 0.4794 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0105 | 0.4794 | 0.565 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0192 | 1 | 1 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0105 | 0.4794 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0105 | 0.4794 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0105 | 0.4794 | 0.5 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0105 | 0.4794 | 0.7218 |
Entamoeba histolytica | protein kinase, putative | 0.0105 | 0.4794 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0192 | 1 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0105 | 0.4794 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.3 | Inhibition of Zea mays cv. Anjou (maize) plastid Protoporphyrinogen IX oxidase assessed as inhibition of protoporphyrin IX by fluorescence spectrophotometry | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.