Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0181 | 0.279 | 0.4211 |
Onchocerca volvulus | 0.0391 | 0.6626 | 1 | |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0391 | 0.6626 | 1 |
Onchocerca volvulus | 0.0181 | 0.279 | 0.4211 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0181 | 0.279 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.2269 | 0.3425 |
Echinococcus granulosus | Endonuclease G | 0.0109 | 0.1468 | 0.5262 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.279 | 0.4211 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0181 | 0.279 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0181 | 0.279 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.279 | 0.4211 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0181 | 0.279 | 0.4211 |
Mycobacterium leprae | hypothetical protein | 0.0028 | 0 | 0.5 |
Giardia lamblia | Phosphatidylinositol-glycan biosynthesis, class O protein | 0.0028 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0109 | 0.1468 | 1 |
Onchocerca volvulus | 0.0181 | 0.279 | 0.4211 | |
Trypanosoma cruzi | endonuclease G, putative | 0.0109 | 0.1468 | 0.5 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0109 | 0.1468 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0391 | 0.6626 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0109 | 0.1468 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0391 | 0.6626 | 1 |
Schistosoma mansoni | endonuclease related | 0.0109 | 0.1468 | 0.2216 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0181 | 0.279 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0181 | 0.279 | 1 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0109 | 0.1468 | 0.2216 |
Trypanosoma cruzi | endonuclease G, putative | 0.0109 | 0.1468 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0181 | 0.279 | 0.4211 |
Echinococcus multilocularis | ectonucleotide | 0.0152 | 0.2269 | 0.8134 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0152 | 0.2269 | 0.8134 |
Trypanosoma brucei | endonuclease G, putative | 0.0109 | 0.1468 | 1 |
Trichomonas vaginalis | pps1 dual specificty phosphatase, putative | 0.0575 | 1 | 0.5 |
Echinococcus granulosus | ectonucleotide | 0.0152 | 0.2269 | 0.8134 |
Plasmodium falciparum | GPI ethanolamine phosphate transferase 3, putative | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0181 | 0.279 | 1 |
Echinococcus multilocularis | Endonuclease G | 0.0109 | 0.1468 | 0.5262 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0181 | 0.279 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0152 | 0.2269 | 0.8134 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0181 | 0.279 | 1 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0109 | 0.1468 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0181 | 0.279 | 1 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0181 | 0.279 | 0.4211 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0109 | 0.1468 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0181 | 0.279 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0181 | 0.279 | 0.4211 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0181 | 0.279 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0109 | 0.1468 | 0.5 |
Leishmania major | endonuclease G, putative | 0.0109 | 0.1468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.279 | 0.4211 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.