Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.1271 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.1271 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase | 0.0727 | 0.2516 | 0.2467 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0549 | 0.0064 | 0.0064 |
Echinococcus granulosus | serine:threonine protein kinase | 0.0727 | 0.2516 | 0.2467 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0549 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0727 | 0.2516 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1271 | 1 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0549 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.0549 | 0.0064 | 0.0255 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0549 | 0.0064 | 0.0064 |
Echinococcus multilocularis | serine:threonine protein kinase | 0.0727 | 0.2516 | 0.2516 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0549 | 0.0064 | 0.0064 |
Echinococcus multilocularis | serine:threonine protein kinase | 0.0727 | 0.2516 | 0.2516 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0727 | 0.2516 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0727 | 0.2516 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1271 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0549 | 0.0064 | 0.0255 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.1271 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/MARK protein kinase | 0.0727 | 0.2516 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 1 mm | Antibacterial activity against Escherichia coli NCTC 12923 assessed as growth inhibition at 50 mg/mL after 24 hr by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 2 mm | Antifungal activity against Candida albicans NCPF 3179 assessed as growth inhibition at 50 mg/mL after 72 hr by agar well diffusion method | ChEMBL. | No reference |
MIC (functional) | = 0.5 mg/ml | Antifungal activity against Candida albicans NCPF 3179 assessed as growth inhibition after 72 hr by serial broth dilution method | ChEMBL. | No reference |
MIC (functional) | = 0.5 mg/ml | Antibacterial activity against Escherichia coli NCTC 12923 assessed as growth inhibition after 24 hr by serial broth dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.