Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0059 | 0.0668 | 0.2868 |
Brugia malayi | jmjC domain containing protein | 0.0097 | 0.1226 | 0.4757 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0173 | 0.2328 | 1 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0173 | 0.2328 | 0.6193 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0338 | 0.0338 |
Echinococcus granulosus | peregrin | 0.003 | 0.0247 | 0.0247 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.027 | 0.0653 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0173 | 0.2328 | 1 |
Brugia malayi | Phosphoglycerate kinase | 0.0173 | 0.2328 | 0.9035 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.019 | 0.2577 | 0.624 |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0.0247 | 0.1061 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.019 | 0.2577 | 0.624 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0247 | 0.1061 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0297 | 0.413 | 1 |
Brugia malayi | Bromodomain containing protein | 0.003 | 0.0247 | 0.0959 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0338 | 0.131 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.019 | 0.2577 | 0.624 |
Plasmodium vivax | small ubiquitin-related modifier, putative | 0.0031 | 0.027 | 0.1158 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0297 | 0.413 | 1 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0173 | 0.2328 | 0.2328 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0338 | 0.0338 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0173 | 0.2328 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0059 | 0.0668 | 0.2868 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0031 | 0.027 | 0.1158 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.019 | 0.2577 | 0.624 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0173 | 0.2328 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0297 | 0.413 | 1 |
Giardia lamblia | Sentrin | 0.0031 | 0.027 | 0.0653 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0173 | 0.2328 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.019 | 0.2577 | 0.624 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0173 | 0.2328 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0416 | 0.0416 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0247 | 0.0959 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0063 | 0.0739 | 0.3173 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0059 | 0.0668 | 0.1617 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0173 | 0.2328 | 0.5638 |
Leishmania major | small ubiquitin protein, putative | 0.0031 | 0.027 | 0.1158 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.003 | 0.0247 | 0.0247 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.0173 | 0.2328 | 1 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0063 | 0.0739 | 0.3173 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0297 | 0.413 | 1 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0173 | 0.2328 | 1 |
Entamoeba histolytica | ubiquitin like protein | 0.0031 | 0.027 | 0.0653 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0173 | 0.2328 | 0.5638 |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.0031 | 0.027 | 0.027 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.019 | 0.2577 | 0.624 |
Loa Loa (eye worm) | PHD-finger family protein | 0.003 | 0.0247 | 0.0959 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0173 | 0.2328 | 0.2328 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0173 | 0.2328 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0297 | 0.413 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.019 | 0.2577 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0247 | 0.1061 |
Leishmania major | hypothetical protein, conserved | 0.0059 | 0.0668 | 0.2868 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0297 | 0.413 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0097 | 0.1226 | 0.1226 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0701 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0297 | 0.413 | 1 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0063 | 0.0739 | 0.3173 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0063 | 0.0739 | 0.3173 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.2328 | 0.9035 |
Plasmodium falciparum | phd finger protein, putative | 0.003 | 0.0247 | 0.1061 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0338 | 0.0338 |
Toxoplasma gondii | small ubiquitin family modifier, putative | 0.0031 | 0.027 | 0.1158 |
Brugia malayi | Ubiquitin-like protein SMT3 | 0.0031 | 0.027 | 0.1046 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0297 | 0.413 | 1 |
Plasmodium falciparum | small ubiquitin-related modifier | 0.0031 | 0.027 | 0.1158 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0297 | 0.413 | 1 |
Onchocerca volvulus | 0.019 | 0.2577 | 1 | |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.003 | 0.0247 | 0.0247 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0247 | 0.0247 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0059 | 0.0668 | 0.1617 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0173 | 0.2328 | 0.2328 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0338 | 0.131 |
Schistosoma mansoni | ubiquitin-like protein sumo/smt3-related | 0.0031 | 0.027 | 0.027 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0097 | 0.1226 | 0.1226 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0416 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0554 | 0.2152 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0173 | 0.2328 | 1 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0173 | 0.2328 | 0.2328 |
Trypanosoma brucei | small ubiquitin-related modifier | 0.0031 | 0.027 | 0.1158 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0247 | 0.0959 |
Giardia lamblia | Phosphoglycerate kinase | 0.0173 | 0.2328 | 0.5638 |
Echinococcus multilocularis | Small ubiquitin modifier 2 | 0.0031 | 0.027 | 0.027 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.0705 | 0.2736 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0145 | 0.1924 | 0.328 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.019 | 0.2577 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.019 | 0.2577 | 0.624 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0173 | 0.2328 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.019 | 0.2577 | 0.624 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0338 | 0.0338 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0063 | 0.0739 | 0.3173 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0701 | 1 | 1 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0173 | 0.2328 | 0.5638 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0.0247 | 0.0598 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.019 | 0.2577 | 1 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0173 | 0.2328 | 1 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0059 | 0.0668 | 0.2868 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0297 | 0.413 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.003 | 0.0247 | 0.0247 |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0173 | 0.2328 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.019 | 0.2577 | 0.624 |
Brugia malayi | Phosphoglycerate kinase | 0.0063 | 0.0739 | 0.2867 |
Trypanosoma brucei | phosphoglycerate kinase, putative | 0.0063 | 0.0739 | 0.3173 |
Trypanosoma cruzi | 3-phosphoglycerate kinase, glycosomal | 0.0063 | 0.0739 | 0.3173 |
Schistosoma mansoni | jumonji domain containing protein | 0.0077 | 0.0936 | 0.0936 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0031 | 0.027 | 0.1158 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0173 | 0.2328 | 1 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0063 | 0.0739 | 0.3173 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0297 | 0.413 | 1 |
Echinococcus multilocularis | peregrin | 0.003 | 0.0247 | 0.0247 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0297 | 0.413 | 1 |
Loa Loa (eye worm) | SMO-1 protein | 0.0031 | 0.027 | 0.1046 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 446 uM | Concentration required to reduce the viability of mock-infected MT-4 cells by 50%. | ChEMBL. | 1732552 |
CC50 (functional) | = 446 uM | Concentration required to reduce the viability of mock-infected MT-4 cells by 50%. | ChEMBL. | 1732552 |
EC50 (functional) | = 82 uM | Concentration required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1. | ChEMBL. | 1732552 |
EC50 (binding) | = 82 uM | Inhibitory concentration against HIV-1 reverse transcriptase | ChEMBL. | 9435895 |
EC50 (binding) | = 82 uM | Inhibitory concentration against HIV-1 reverse transcriptase | ChEMBL. | 9435895 |
Log 1/C (functional) | = 4.09 | Tested for 50% protection of MT-4 cells from HIV infection | ChEMBL. | No reference |
Selectivity index (functional) | = 5.3 | Ratio of EC50/CC50 | ChEMBL. | 1732552 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.