Detailed information for compound 1815083

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 518.627 | Formula: C28H30N4O4S
  • H donors: 2 H acceptors: 3 LogP: 5.36 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)C1=C(C)NC(=C(C1c1cnc(n1Nc1ccccc1)SC)C(=O)OCc1ccccc1)C
  • InChi: 1S/C28H30N4O4S/c1-5-35-26(33)23-18(2)30-19(3)24(27(34)36-17-20-12-8-6-9-13-20)25(23)22-16-29-28(37-4)32(22)31-21-14-10-7-11-15-21/h6-16,25,30-31H,5,17H2,1-4H3
  • InChiKey: PTGNGDXCVQAGJU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) voltage-dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav1 Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni voltage-gated cation channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma congolense Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent N-type calcium channel subunit alpha-1B, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Muscle calcium channel subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei gambiense calcium channel protein, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav2A Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii transporter, cation channel family protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni cd63 antigen-like Voltage-dependent L-type calcium channel subunit alpha-1C   169 aa 181 aa 22.1 %
Onchocerca volvulus 60S acidic ribosomal protein P2 homolog Voltage-dependent L-type calcium channel subunit alpha-1C   169 aa 144 aa 24.3 %
Echinococcus multilocularis sodium channel protein Voltage-dependent L-type calcium channel subunit alpha-1C   169 aa 145 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi voltage-dependent calcium channel 0.0242 0.1856 0.3869
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0285 0.3184 0.877
Echinococcus multilocularis two pore calcium channel protein 1 0.0242 0.1856 0.1141
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0242 0.1856 0.3869
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0273 0.2812 0.1175
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0478 0.9193 0.9122
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Echinococcus multilocularis potassium voltage gated channel protein 0.0242 0.1856 0.1141
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0285 0.3184 0.2586
Echinococcus multilocularis short transient receptor potential channel 6 0.0242 0.1856 0.1141
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0242 0.1856 0.1141
Schistosoma mansoni calcium-activated potassium channel 0.0242 0.1856 0.1141
Brugia malayi vesicle-fusing ATPase 0.0296 0.3518 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0285 0.3184 0.1811
Entamoeba histolytica cdc48-like protein, putative 0.0478 0.9193 0.5
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Echinococcus multilocularis potassium voltage gated channel protein 0.0242 0.1856 0.1141
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0273 0.2812 0.7398
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0242 0.1856 0.1141
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0478 0.9193 1
Loa Loa (eye worm) steroid hormone receptor 0.0273 0.2812 0.7398
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0242 0.1856 0.3869
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0242 0.1856 0.3869
Schistosoma mansoni thyroid hormone receptor 0.0273 0.2812 0.2181
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0242 0.1856 0.1141
Brugia malayi Cyclic-nucleotide gated cation channel 0.0242 0.1856 0.3869
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0504 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0273 0.2812 0.1175
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0242 0.1856 0.3869
Echinococcus multilocularis voltage gated potassium channel 0.0242 0.1856 0.1141
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0273 0.2812 0.2181
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0273 0.2812 0.1175
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0273 0.2812 0.2181
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0273 0.2812 0.7398
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0242 0.1856 0.3869
Brugia malayi photoreceptor-specific nuclear receptor 0.0273 0.2812 0.7398
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0273 0.2812 0.1175
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0273 0.2812 0.7398
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0273 0.2812 0.2181
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0242 0.1856 0.3869
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0504 1 1
Loa Loa (eye worm) hypothetical protein 0.0273 0.2812 0.7398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0273 0.2812 0.7398
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0242 0.1856 0.1141
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0273 0.2812 0.1175
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0273 0.2812 0.2181
Loa Loa (eye worm) vesicle-fusing ATPase 0.0296 0.3518 1
Echinococcus multilocularis transient receptor potential cation channel 0.0242 0.1856 0.1141
Echinococcus multilocularis transient receptor potential cation channel 0.0242 0.1856 0.1141
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0242 0.1856 0.1141
Loa Loa (eye worm) voltage-dependent calcium channel 0.0285 0.3184 0.877
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0242 0.1856 0.3869
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0273 0.2812 0.7398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0273 0.2812 0.7398
Loa Loa (eye worm) ion channel NompC 0.0242 0.1856 0.3869
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Echinococcus multilocularis transient receptor potential cation channel 0.0242 0.1856 0.1141
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0242 0.1856 0.1141
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0242 0.1856 0.3869
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0242 0.1856 0.1141
Echinococcus multilocularis transient receptor potential cation channel 0.0242 0.1856 0.1141
Brugia malayi ion channel NompC 0.0242 0.1856 0.3869
Brugia malayi ecdysteroid receptor 0.0273 0.2812 0.7398
Brugia malayi cation channel family protein 0.0242 0.1856 0.3869
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0242 0.1856 0.1141
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0242 0.1856 0.1141
Brugia malayi olfactory channel protein osm-9 0.0242 0.1856 0.3869
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0242 0.1856 0.1141
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0273 0.2812 0.7398
Echinococcus multilocularis potassium voltage gated channel protein 0.0242 0.1856 0.1141
Schistosoma mansoni voltage-gated cation channel 0.0285 0.3184 0.2586
Mycobacterium tuberculosis Putative conserved ATPase 0.0302 0.3706 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0273 0.2812 0.2181
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0273 0.2812 0.7398
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0273 0.2812 0.7398
Trypanosoma brucei Valosin-containing protein 0.0478 0.9193 1
Echinococcus multilocularis ryanodine receptor 44f 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0273 0.2812 0.7398
Brugia malayi valosin containing protein 0.0296 0.3518 1
Echinococcus multilocularis voltage dependent calcium channel 0.0285 0.3184 0.2586
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0242 0.1856 0.1141
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0242 0.1856 0.3869
Echinococcus multilocularis transient receptor potential cation channel 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0273 0.2812 0.7398
Brugia malayi nuclear receptor NHR-88 0.0273 0.2812 0.7398
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0273 0.2812 0.7398
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0296 0.3518 1
Echinococcus multilocularis potassium large conductance calcium activated 0.0242 0.1856 0.1141
Echinococcus multilocularis calcium activated potassium channel 0.0242 0.1856 0.1141
Echinococcus multilocularis voltage dependent calcium channel 0.0285 0.3184 0.2586
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0242 0.1856 0.1141
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0478 0.9193 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0242 0.1856 0.3869
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0273 0.2812 0.7398
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0285 0.3184 0.1631
Echinococcus multilocularis shaker cognate 0.0242 0.1856 0.1141
Schistosoma mansoni two-pore calcium channel 0.0242 0.1856 0.1141
Schistosoma mansoni vesicular amine transporter 0.0242 0.1856 0.1141
Echinococcus multilocularis two pore calcium channel protein 2 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0285 0.3184 0.2586
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0285 0.3184 0.2586
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0285 0.3184 0.877
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Loa Loa (eye worm) calcium channel 0.0285 0.3184 0.877
Brugia malayi nuclear hormone receptor 0.0273 0.2812 0.7398
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0478 0.9193 0.5
Brugia malayi steroid hormone receptor 0.0273 0.2812 0.7398
Brugia malayi Steroid receptor seven-up type 2 0.0273 0.2812 0.7398
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Echinococcus multilocularis transfer RNA-Gly 0.0242 0.1856 0.1141
Schistosoma mansoni transient receptor potential channel 0.0242 0.1856 0.1141
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0273 0.2812 0.1175
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0242 0.1856 0.1141
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0273 0.2812 0.2181
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Onchocerca volvulus Protein ultraspiracle homolog 0.0273 0.2812 0.1175
Schistosoma mansoni hypothetical protein 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Echinococcus multilocularis ecdysone induced protein 78C 0.0273 0.2812 0.2181
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0273 0.2812 0.7398
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Loa Loa (eye worm) ryanodine receptor 0.0242 0.1856 0.3869
Schistosoma mansoni coup transcription factor 0.0273 0.2812 0.2181
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0242 0.1856 0.3869
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0273 0.2812 0.7398
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0273 0.2812 0.7398
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0273 0.2812 0.7398
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0302 0.3706 0.2272
Echinococcus multilocularis voltage gated potassium channel 0.0242 0.1856 0.1141
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0242 0.1856 0.3869
Schistosoma mansoni transient receptor potential channel 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Trypanosoma cruzi Valosin-containing protein, putative 0.0478 0.9193 1
Giardia lamblia AAA family ATPase 0.0302 0.3706 0.5
Echinococcus multilocularis transient receptor potential gamma protein 0.0242 0.1856 0.1141
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0273 0.2812 0.7398
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0242 0.1856 0.3869
Schistosoma mansoni steroid hormone receptor ad4bp 0.0273 0.2812 0.2181
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0273 0.2812 0.1175
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0273 0.2812 0.1175
Loa Loa (eye worm) hypothetical protein 0.0273 0.2812 0.7398
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0242 0.1856 0.1141
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Echinococcus multilocularis sodium leak channel non selective protein 0.0242 0.1856 0.1141
Mycobacterium ulcerans ATPase 0.0302 0.3706 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0273 0.2812 0.7398
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0242 0.1856 0.3869
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Schistosoma mansoni thyroid hormone receptor 0.0273 0.2812 0.2181
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0242 0.1856 0.1141
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0273 0.2812 0.2181
Schistosoma mansoni voltage-dependent calcium channel 0.0242 0.1856 0.1141
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0504 1 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0242 0.1856 0.3869
Echinococcus multilocularis hyperpolarization activated cyclic 0.0242 0.1856 0.1141
Echinococcus multilocularis hyperpolarization activated cyclic 0.0242 0.1856 0.1141
Schistosoma mansoni retinoic acid receptor RXR 0.0273 0.2812 0.2181
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0285 0.3184 0.1631
Schistosoma mansoni nuclear hormone receptor 0.0273 0.2812 0.2181
Brugia malayi Transient-receptor-potential like protein 0.0242 0.1856 0.3869
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Loa Loa (eye worm) voltage-gated calcium channel 0.0242 0.1856 0.3869
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0242 0.1856 0.1141
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0273 0.2812 0.2181
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0285 0.3184 0.2586
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0242 0.1856 0.3869
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0273 0.2812 0.1175
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0242 0.1856 0.3869
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0285 0.3184 0.2586
Echinococcus multilocularis thyroid hormone receptor alpha 0.0273 0.2812 0.2181
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0273 0.2812 0.2181
Brugia malayi Nuclear hormone receptor-like 1 0.0273 0.2812 0.7398
Schistosoma mansoni ryanodine receptor related 0.0242 0.1856 0.1141
Echinococcus multilocularis sodium channel protein 0.0242 0.1856 0.1141
Echinococcus multilocularis conserved hypothetical protein 0.0242 0.1856 0.1141
Echinococcus multilocularis transient receptor potential cation channel 0.0242 0.1856 0.1141
Onchocerca volvulus 0.0273 0.2812 0.1175
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0504 1 1
Brugia malayi hypothetical protein 0.0242 0.1856 0.3869
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Onchocerca volvulus Bile acid receptor homolog 0.0273 0.2812 0.1175
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0242 0.1856 0.1141
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0242 0.1856 0.3869
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0273 0.2812 0.2181
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0242 0.1856 0.1141
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0242 0.1856 0.1141
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0285 0.3184 0.2586
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0273 0.2812 0.2181
Echinococcus multilocularis potassium voltage gated channel protein 0.0242 0.1856 0.1141
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0478 0.9193 0.5
Schistosoma mansoni 60S ribosomal protein L21 0.0242 0.1856 0.1141
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0273 0.2812 0.7398
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0242 0.1856 0.1141
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Toxoplasma gondii transporter, cation channel family protein 0.0285 0.3184 0.1631
Echinococcus multilocularis short transient receptor potential channel 6 0.0242 0.1856 0.1141
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0273 0.2812 0.7398
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0273 0.2812 0.7398
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0273 0.2812 0.2181
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0273 0.2812 0.2181
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0285 0.3184 0.1631
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0242 0.1856 0.1141
Echinococcus granulosus voltage dependent calcium channel 0.0285 0.3184 0.1631
Echinococcus multilocularis FTZ F1 alpha 0.0273 0.2812 0.2181
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0285 0.3184 0.1811
Echinococcus granulosus FTZ F1 alpha 0.0273 0.2812 0.1175
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.1856 0.1141
Schistosoma mansoni voltage-gated ion channel 0.0242 0.1856 0.1141
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0285 0.3184 0.877
Toxoplasma gondii cell division protein CDC48AP 0.0302 0.3706 0.2272
Echinococcus granulosus voltage dependent calcium channel 0.0285 0.3184 0.1631
Toxoplasma gondii cell division protein CDC48CY 0.0504 1 1
Schistosoma mansoni transient receptor potential channel 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0242 0.1856 0.3869
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0273 0.2812 0.7398
Loa Loa (eye worm) voltage-gated potassium channel 0.0242 0.1856 0.3869
Schistosoma mansoni transient receptor potential channel 4 0.0242 0.1856 0.1141
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0242 0.1856 0.1141
Loa Loa (eye worm) hypothetical protein 0.0273 0.2812 0.7398
Brugia malayi cation channel family protein 0.0242 0.1856 0.3869
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0273 0.2812 0.7398
Loa Loa (eye worm) hypothetical protein 0.0273 0.2812 0.7398

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.86 10'-9M Antagonist activity at Cavia porcellus albino (guinea pig) calcium channel assessed as inhibition of KCl-induced ileal longitudinal smooth muscle contraction ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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