Detailed information for compound 1816776
Basic information
Technical information
- Name: Unnamed compound
- MW: 600.569 | Formula: C28H25FN2O10S
-
H donors: 3
H acceptors: 5
LogP: 3.46
Rotable bonds: 8
Rule of 5 violations (Lipinski): 2 - SMILES: COc1cc(cc(c1O)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@@H](c2c1cc1OCOc1c2)NC(=O)NS(=O)(=O)c1ccc(cc1)F
- InChi: 1S/C28H25FN2O10S/c1-37-21-7-13(8-22(38-2)26(21)32)23-16-9-19-20(41-12-40-19)10-17(16)25(18-11-39-27(33)24(18)23)30-28(34)31-42(35,36)15-5-3-14(29)4-6-15/h3-10,18,23-25,32H,11-12H2,1-2H3,(H2,30,31,34)/t18-,23+,24-,25+/m0/s1
- InChiKey: GIWQWLURJDHYMG-LVEBQJTPSA-N
Network
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Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Trypanosoma brucei | Pseudokinase, putative | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine protein kinase fes (fps) (ptk group IV) | 0.0239 | 1 | 1 |
| Brugia malayi | Adenylate and Guanylate cyclase catalytic domain containing protein | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Plasmodium falciparum | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0239 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0239 | 1 | 1 |
| Toxoplasma gondii | STE kinase | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0239 | 1 | 1 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK/ABL protein kinase | 0.0239 | 1 | 1 |
| Giardia lamblia | Kinase, NEK | 0.0239 | 1 | 0.5 |
| Brugia malayi | hypothetical protein | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | protein tyrosine kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | ephrin receptor | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | natriuretic peptide receptor 1 | 0.0239 | 1 | 1 |
| Plasmodium vivax | tyrosine kinase-like protein, putative | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Brugia malayi | ephrin receptor 1 precursor | 0.0239 | 1 | 1 |
| Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0239 | 1 | 1 |
| Brugia malayi | protein-tyrosine kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | insulin receptor | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | c src tyrosine kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | activated cdc42 kinase 1 | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | protein kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK/KIN6 protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Toxoplasma gondii | protein kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | serine-threonine protein kinase, putative | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0239 | 1 | 1 |
| Echinococcus granulosus | receptor type guanylyl cyclase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | retinal guanylyl cyclase 2 | 0.0239 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/DDR protein kinase | 0.0239 | 1 | 1 |
| Brugia malayi | SH2 domain containing protein | 0.0239 | 1 | 1 |
| Entamoeba histolytica | serine/threonine kinase, putative | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | receptor protein kinase, putative | 0.0239 | 1 | 0.5 |
| Trypanosoma brucei | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TKL/MLK/TAK1 protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0239 | 1 | 1 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase transmembrane receptor | 0.0239 | 1 | 1 |
| Echinococcus granulosus | tyrosine protein kinase Srms | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase csk | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FAK protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | kinase suppressor of Ras 1 | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TKL/MLK/HH498 protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | cysteine surface protein, putative | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | mitogen-activated protein kinase kinase kinase 9 | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK protein kinase | 0.0239 | 1 | 1 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Echinococcus multilocularis | macrophage colony stimulating factor 1 receptor | 0.0239 | 1 | 1 |
| Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine protein kinase csk | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein | 0.0239 | 1 | 0.5 |
| Brugia malayi | intermediate filament protein | 0.003 | 0.0615 | 0.0615 |
| Entamoeba histolytica | hypothetical protein | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK protein kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | protein kinase | 0.0239 | 1 | 1 |
| Brugia malayi | Tyrosine-protein kinase F09A5.2 in chromosome X, putative | 0.0239 | 1 | 1 |
| Trypanosoma cruzi | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | atrial natriuretic peptide receptor 1 | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | activated cdc42 kinase 1 | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK/RYK protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0615 | 0.0615 |
| Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine protein kinase fes (fps) (ptk group IV) | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Plasmodium falciparum | tyrosine kinase-like protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | protein tyrosine kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TKL/MLK/ILK protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | AGC family protein kinase | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0239 | 1 | 1 |
| Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0239 | 1 | 1 |
| Schistosoma mansoni | protein kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | tyrosine protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | protein kinase atn1, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | ephrin receptor | 0.0239 | 1 | 1 |
| Echinococcus granulosus | activin receptor type | 0.0239 | 1 | 1 |
| Toxoplasma gondii | Tyrosine kinase-like (TKL) protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | activin receptor type | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK protein kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0239 | 1 | 1 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK/ACK protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.059 | 0.059 |
| Echinococcus granulosus | retinal guanylyl cyclase 2 | 0.0239 | 1 | 1 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Echinococcus granulosus | dual specificity testis-specific protein kinase | 0.0239 | 1 | 1 |
| Brugia malayi | Tyrosine-protein kinase PR2 | 0.0239 | 1 | 1 |
| Brugia malayi | Probable tyrosine-protein kinase kin-31 | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | FL cytokine receptor | 0.0239 | 1 | 1 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Entamoeba histolytica | serine/threonine kinase, putative | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Brugia malayi | Guanylyl cyclase protein 23 | 0.0239 | 1 | 1 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase Fes:Fps | 0.0239 | 1 | 1 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase csk | 0.0239 | 1 | 1 |
| Echinococcus granulosus | tyrosine protein kinase csk | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0239 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase shark | 0.0239 | 1 | 1 |
| Onchocerca volvulus | Tyrosine kinase homolog | 0.0239 | 1 | 1 |
| Leishmania major | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | protein kinase | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/ALK protein kinase | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Echinococcus granulosus | tyrosine protein kinase transmembrane receptor | 0.0239 | 1 | 1 |
| Echinococcus granulosus | c src tyrosine kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine-protein kinase fps85d | 0.0239 | 1 | 1 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0239 | 1 | 1 |
| Brugia malayi | SH2 domain containing protein | 0.0239 | 1 | 1 |
| Entamoeba histolytica | serine/threonine kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine protein kinase pr2 | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0615 | 0.0615 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/Met protein kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | atrial natriuretic peptide receptor 1 | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | epidermal growth factor receptor | 0.0239 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | protein kinase domain-containing protein | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | epidermal growth factor receptor | 0.0239 | 1 | 1 |
| Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0239 | 1 | 1 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | retinal guanylyl cyclase 2 | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | transfer RNA-Thr | 0.0239 | 1 | 1 |
| Echinococcus granulosus | tyrosine kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Leishmania major | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Echinococcus granulosus | 3'partial|retinal guanylyl cyclase 2 | 0.0239 | 1 | 1 |
| Brugia malayi | Probable tyrosine-protein kinase kin-31 | 0.0239 | 1 | 1 |
| Echinococcus granulosus | epidermal growth factor receptor | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Brugia malayi | proto-oncogene tyrosine-protein kinase FER | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Brugia malayi | hypothetical protein | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/ROR protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | br serine/threonine-protein kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosin kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | retinal guanylyl cyclase 2 | 0.0239 | 1 | 1 |
| Echinococcus granulosus | activated cdc42 kinase 1 | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | integrin linked protein kinase | 0.0239 | 1 | 1 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine protein kinase transmembrane receptor | 0.0239 | 1 | 1 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0615 | 0.0615 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein | 0.0239 | 1 | 0.5 |
| Onchocerca volvulus | Tyrosine kinase receptor Cad96Ca homolog | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | SRC-1 | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | serine/threonine kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Schistosoma mansoni | protein kinase | 0.0239 | 1 | 1 |
| Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | protein KINase family member (kin 25) | 0.0239 | 1 | 1 |
| Giardia lamblia | Protein 21.1 | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/EPH protein kinase | 0.0239 | 1 | 1 |
| Giardia lamblia | Kinase, NEK | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein | 0.0239 | 1 | 0.5 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | retinal guanylyl cyclase 2 | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | kinase suppressor of Ras 1 | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine protein kinase shark | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase with ankyrin repeats, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosin kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0615 | 0.0615 |
| Echinococcus granulosus | tyrosine kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | ephrin type A receptor 4 A | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | serine/threonine kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase pr2 | 0.0239 | 1 | 1 |
| Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine kinase | 0.0239 | 1 | 1 |
| Plasmodium vivax | tyrosine kinase-like protein, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Trypanosoma brucei | Flagellum attachment zone protein 20 | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | insulin receptor | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Trichomonas vaginalis | protein tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | receptor protein kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Brugia malayi | Adenylate and Guanylate cyclase catalytic domain containing protein | 0.0239 | 1 | 1 |
| Plasmodium falciparum | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | src-type protein tyrosine kinase-related | 0.0239 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | raf serine:threonine protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase HCK | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | serine/threonine-protein kinase wnk, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase transmembrane receptor | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | protein tyrosine kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Entamoeba histolytica | ankyrin repeat protein | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0239 | 1 | 1 |
| Brugia malayi | integrin-linked kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | tyrosine protein kinase csk | 0.0239 | 1 | 1 |
| Brugia malayi | Receptor family ligand binding region containing protein | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0239 | 1 | 1 |
| Echinococcus granulosus | integrin linked protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Echinococcus granulosus | tyrosine protein kinase Blk | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/CSK protein kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Brugia malayi | C-terminal src kinase protein 1 | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Plasmodium falciparum | tyrosine kinase-like protein | 0.0239 | 1 | 0.5 |
| Brugia malayi | SRC-1 | 0.0239 | 1 | 1 |
| Schistosoma mansoni | protein kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TK family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TKL/RAF/KSR protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | STE family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0239 | 1 | 1 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0239 | 1 | 1 |
| Giardia lamblia | Kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Toxoplasma gondii | protein kinase | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Trypanosoma cruzi | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | protein kinase | 0.0239 | 1 | 1 |
| Echinococcus granulosus | retinal guanylyl cyclase 2 | 0.0239 | 1 | 1 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosin kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Brugia malayi | Raf kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosine kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0239 | 1 | 1 |
| Plasmodium vivax | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosine- protein kinase 2, putative | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Plasmodium falciparum | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase, putative | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | tyrosin kinase, putative | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Entamoeba histolytica | serine/threonine kinase, putative | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Toxoplasma gondii | Tyrosine kinase-like (TKL) protein | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | ephrin type A receptor 4 A | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein | 0.0239 | 1 | 0.5 |
| Trypanosoma brucei | AGC/RSK family serine/threonine kinase, putative | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0239 | 1 | 1 |
| Onchocerca volvulus | 0.0239 | 1 | 1 | |
| Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein tyrosine kinase domain-containing protein | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK protein kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | natriuretic peptide receptor 1 | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | heat shock protein 70 | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0239 | 1 | 1 |
| Schistosoma mansoni | protein kinase | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine protein kinase csk | 0.0239 | 1 | 1 |
| Schistosoma mansoni | tyrosine-protein kinase fps85d | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | serine/threonine protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0239 | 1 | 1 |
| Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Entamoeba histolytica | ankyrin repeat protein | 0.0239 | 1 | 0.5 |
| Echinococcus multilocularis | tyrosine protein kinase Fes:Fps | 0.0239 | 1 | 1 |
| Echinococcus granulosus | epidermal growth factor receptor | 0.0239 | 1 | 1 |
| Entamoeba histolytica | leucine-rich repeat domain-containing protein | 0.0239 | 1 | 0.5 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Brugia malayi | Protein kinase domain containing protein | 0.0239 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0239 | 1 | 0.5 |
| Loa Loa (eye worm) | TK protein kinase | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | ankyrin repeat-containing protein, putative | 0.0239 | 1 | 0.5 |
| Echinococcus granulosus | tyrosine kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/FER protein kinase | 0.0239 | 1 | 1 |
| Schistosoma mansoni | serine/threonine RGC | 0.0239 | 1 | 1 |
| Trichomonas vaginalis | TKL family protein kinase | 0.0239 | 1 | 0.5 |
| Schistosoma mansoni | protein kinase | 0.0239 | 1 | 1 |
| Loa Loa (eye worm) | TK/INSR protein kinase | 0.0239 | 1 | 1 |
| Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0239 | 1 | 1 |
| Echinococcus multilocularis | tyrosine protein kinase csk | 0.0239 | 1 | 1 |
| Brugia malayi | Furin-like cysteine rich region family protein | 0.0239 | 1 | 1 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| IC50 (functional) | = 9 uM | Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay | ChEMBL. | 24332656 |
Phenotypes
Whole-cell/tissue/organism interactions
| Species name | Source | Reference | Is orphan |
|---|---|---|---|
| Homo sapiens | ChEMBL23 | 24332656 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL3105055
Bibliographic References
No literature references available for this target.
If you have references for this compound, please enter them in a user comment (below) or Contact us.