TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 398.456 | Formula: C21H26N4O4
H donors: 0 H acceptors: 4 LogP: 3.51 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)N1[C@@H]2CC[C@H]1C[C@H](C2)Oc1ncnc(c1C)Oc1cccnc1C
InChi: 1S/C21H26N4O4/c1-4-27-21(26)25-15-7-8-16(25)11-17(10-15)28-19-13(2)20(24-12-23-19)29-18-6-5-9-22-14(18)3/h5-6,9,12,15-17H,4,7-8,10-11H2,1-3H3/t15-,16+,17+
InChiKey: ZJRFPSHTPAIAJZ-FVQHAEBGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	G protein-coupled receptor 119	Starlite/ChEMBL	References
Mus musculus	G-protein coupled receptor 119	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	follicle stimulating hormone receptor	G protein-coupled receptor 119	335 aa	274 aa	22.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.008	0.014	0.014
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Echinococcus multilocularis	epidermal growth factor receptor	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0031	0.0022	1
Schistosoma mansoni	protein tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.4164	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Trypanosoma cruzi	protein kinase, putative	0.0031	0.0022	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0031	0.0022	0.4531
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0031	0.0022	0.0022
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0038	0.0038	0.3183
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0031	0.0022	0.0022
Echinococcus multilocularis	neuropeptide s receptor	0.0548	0.127	0.127
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Toxoplasma gondii	aldehyde dehydrogenase	0.0071	0.0119	1
Entamoeba histolytica	hypothetical protein	0.0031	0.0022	0.4531
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Echinococcus multilocularis	insulin receptor	0.0031	0.0022	0.0022
Echinococcus granulosus	activated cdc42 kinase 1	0.0031	0.0022	0.0022
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0049	0.0049
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	hypothetical protein	0.0035	0.0031	0.6298
Echinococcus multilocularis	tyrosine protein kinase csk	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	hypothetical protein	0.0031	0.0022	0.4531
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0031	0.0022	0.0022
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0031	0.0022	0.0022
Giardia lamblia	Protein 21.1	0.0031	0.0022	1
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0031	0.0022	0.0022
Entamoeba histolytica	hypothetical protein	0.0042	0.0049	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0031	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Entamoeba histolytica	hypothetical protein, conserved	0.0031	0.0022	0.4531
Entamoeba histolytica	hypothetical protein	0.0042	0.0049	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Entamoeba histolytica	serine/threonine kinase, putative	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0294	0.0294
Echinococcus multilocularis	geminin	0.0199	0.0426	0.0426
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Brugia malayi	integrin-linked kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0031	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0294	0.0294
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase pr2	0.0031	0.0022	0.0022
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0031	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.4164	1	1
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0037	0.0036	0.0036
Brugia malayi	Furin-like cysteine rich region family protein	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0031	0.0022	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0031	0.0022	0.0022
Giardia lamblia	Kinase, NEK	0.0031	0.0022	1
Schistosoma mansoni	protein kinase	0.0031	0.0022	0.0022
Plasmodium vivax	protein kinase, putative	0.0031	0.0022	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0117	0.0229	0.0229
Trichomonas vaginalis	STE family protein kinase	0.0031	0.0022	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0038	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Onchocerca volvulus	Huntingtin homolog	0.0144	0.0294	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0031	0.0022	0.0022
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0031	0.0022	0.0022
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0022	0.0022
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0031	0.0022	1
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	natriuretic peptide receptor 1	0.0031	0.0022	0.0022
Echinococcus granulosus	kinase suppressor of Ras 1	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0031	0.0022	0.0022
Echinococcus granulosus	protein kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase HCK	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0031	0.0022	0.0022
Echinococcus granulosus	protein tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	c src tyrosine kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Brugia malayi	Raf kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0035	0.0031	0.6298
Echinococcus granulosus	epidermal growth factor receptor	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus multilocularis	sodium channel protein	0.0038	0.0038	0.0038
Entamoeba histolytica	serine/threonine kinase, putative	0.0031	0.0022	0.4531
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0031	0.0022	0.0022
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0071	0.0119	1
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Echinococcus multilocularis	activin receptor type	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0119	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0031	0.0022	0.0022
Brugia malayi	Guanylyl cyclase protein 23	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Schistosoma mansoni	hypothetical protein	0.0037	0.0036	0.0036
Brugia malayi	ephrin receptor 1 precursor	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Echinococcus multilocularis	neuropeptide receptor A26	0.0548	0.127	0.127
Echinococcus granulosus	tyrosine protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0031	0.0022	0.0022
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.4164	1	1
Schistosoma mansoni	protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	protein kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Echinococcus multilocularis	GPCR, family 2	0.0037	0.0036	0.0036
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Trichomonas vaginalis	protein kinase atn1, putative	0.0031	0.0022	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0031	0.0022	0.0022
Brugia malayi	latrophilin 2 splice variant baaae	0.008	0.014	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0119	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0	0.5
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.0119	0.0119
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Entamoeba histolytica	hypothetical protein	0.0031	0.0022	0.4531
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0031	0.0022	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0031	0.0022	0.0022
Entamoeba histolytica	hypothetical protein	0.0031	0.0022	0.4531
Brugia malayi	hypothetical protein	0.0144	0.0294	0.0294
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0031	0.0022	0.0022
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0031	0.0022	1
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Brugia malayi	hypothetical protein	0.0031	0.0022	0.0022
Schistosoma mansoni	protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0031	0.0022	0.0022
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0031	0.0022	0.0022
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0071	0.0119	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0037	0.0036	0.0036
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0031	0.0022	0.0022
Echinococcus granulosus	raf serine:threonine protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase csk	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Giardia lamblia	Kinase, NEK	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0049	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0022	1
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Trichomonas vaginalis	TK family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	receptor protein kinase, putative	0.0031	0.0022	0.4531
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK/INSR protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0199	0.0426	0.0426
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0031	0.0022	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.014	0.014
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0022	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Brugia malayi	SH2 domain containing protein	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Entamoeba histolytica	serine/threonine kinase, putative	0.0031	0.0022	0.4531
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus multilocularis	transfer RNA-Thr	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0031	0.0022	0.0022
Echinococcus multilocularis	protein kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0031	0.0022	0.0022
Onchocerca volvulus	Huntingtin homolog	0.0144	0.0294	1
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Schistosoma mansoni	ephrin receptor	0.0031	0.0022	0.0022
Plasmodium falciparum	protein kinase, putative	0.0031	0.0022	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0031	0.0022	0.0022
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0031	0.0022	0.0022
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Loa Loa (eye worm)	TK/Met protein kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	neuropeptide s receptor	0.0548	0.127	0.127
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0022	0.0022
Schistosoma mansoni	protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase shark	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase csk	0.0031	0.0022	0.0022
Trypanosoma cruzi	protein kinase, putative	0.0031	0.0022	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Schistosoma mansoni	protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Schistosoma mansoni	hypothetical protein	0.0037	0.0036	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0022	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0031	0.6298
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0031	0.0022	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0031	0.0022	0.0022
Echinococcus multilocularis	protein tyrosine kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0031	0.0022	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0037	0.0036	0.0036
Echinococcus granulosus	tyrosine protein kinase Srms	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosin kinase, putative	0.0031	0.0022	0.4531
Giardia lamblia	Kinase	0.0031	0.0022	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0031	0.0022	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0031	0.0022	0.0022
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0031	0.0022	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0031	0.0022	0.0022
Echinococcus multilocularis	FL cytokine receptor	0.0031	0.0022	0.0022
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0022	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0031	0.0022	0.1856
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0049	0.0049
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosin kinase, putative	0.0031	0.0022	0.4531
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	heat shock protein 70	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0031	0.0022	0.4531
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Trichomonas vaginalis	AGC family protein kinase	0.0031	0.0022	1
Toxoplasma gondii	STE kinase	0.0031	0.0022	0.1856
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0031	0.0022	0.0022
Brugia malayi	Receptor family ligand binding region containing protein	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0117	0.0229	0.0229
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Entamoeba histolytica	serine/threonine kinase, putative	0.0031	0.0022	0.4531
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0031	0.0022	0.4531
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0031	0.0022	0.0022
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0031	0.0022	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0117	0.0229	0.0229
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0022	0.0022
Echinococcus granulosus	activin receptor type	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0031	0.0022	0.0022
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Echinococcus multilocularis	tyrosine protein kinase csk	0.0031	0.0022	0.0022
Brugia malayi	protein-tyrosine kinase	0.0031	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0031	0.0022	0.0022
Echinococcus granulosus	ephrin type A receptor 4 A	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0031	0.0022	0.0022
Schistosoma mansoni	protein kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	neuropeptide receptor A26	0.0548	0.127	0.127
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	SRC-1	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Schistosoma mansoni	protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	cysteine surface protein, putative	0.0031	0.0022	0.4531
Loa Loa (eye worm)	serine/threonine protein kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine kinase	0.0031	0.0022	0.0022
Brugia malayi	C-terminal src kinase protein 1	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Echinococcus granulosus	integrin linked protein kinase	0.0031	0.0022	0.0022
Brugia malayi	Latrophilin receptor protein 2	0.0037	0.0036	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0037	0.0036	0.0036
Echinococcus granulosus	GPCR family 2	0.0037	0.0036	0.0036
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0031	0.0022	0.0022
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0031	0.0022	0.0022
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0049	0.0049
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0037	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0037	0.0036	0.0036
Echinococcus multilocularis	tyrosine protein kinase csk	0.0031	0.0022	0.0022
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.4164	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.0119	0.0119
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase csk	0.0031	0.0022	0.0022
Entamoeba histolytica	ankyrin repeat protein	0.0031	0.0022	0.4531
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0031	0.0022	0.0022
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Leishmania major	protein kinase, putative	0.0031	0.0022	0.1856
Schistosoma mansoni	protein kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0031	0.0022	0.0022
Schistosoma mansoni	protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Leishmania major	protein kinase, putative	0.0031	0.0022	0.1856
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Entamoeba histolytica	receptor protein kinase, putative	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Brugia malayi	SRC-1	0.0031	0.0022	0.0022
Echinococcus granulosus	geminin	0.0199	0.0426	0.0426
Entamoeba histolytica	hypothetical protein	0.0035	0.0031	0.6298
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Entamoeba histolytica	ankyrin repeat protein	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Leishmania major	hypothetical protein, conserved	0.0031	0.0022	0.1856
Echinococcus granulosus	insulin receptor	0.0031	0.0022	0.0022
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0031	0.0022	0.1856
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0199	0.0426	0.0426
Brugia malayi	Tyrosine-protein kinase PR2	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0031	0.0022	0.0022
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0031	0.0022	0.0022
Echinococcus granulosus	receptor type guanylyl cyclase	0.0031	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0031	0.0022	0.4531
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0042	0.0049	0.0049
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0031	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0229	0.0229
Echinococcus multilocularis	protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus granulosus	epidermal growth factor receptor	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine protein kinase csk	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0031	0.0022	0.0022
Entamoeba histolytica	hypothetical protein	0.0031	0.0022	0.4531
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0071	0.0119	0.0119
Entamoeba histolytica	protein kinase, putative	0.0035	0.0031	0.6298
Entamoeba histolytica	protein kinase domain containing protein	0.0031	0.0022	0.4531
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus multilocularis	tyrosine kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Schistosoma mansoni	ephrin receptor	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus granulosus	sodium channel protein	0.0038	0.0038	0.0038
Schistosoma mansoni	hypothetical protein	0.0037	0.0036	0.0036
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0022	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0031	0.0022	1
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Trypanosoma brucei	Pseudokinase, putative	0.0031	0.0022	1
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK/EPH protein kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	integrin linked protein kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Echinococcus granulosus	activated cdc42 kinase 1	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK/CSK protein kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0036	0.0036
Schistosoma mansoni	serine/threonine RGC	0.0031	0.0022	0.0022
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0022	1
Plasmodium falciparum	protein kinase, putative	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0037	0.0036	0.0036
Entamoeba histolytica	hypothetical protein	0.0042	0.0049	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	hypothetical protein	0.0031	0.0022	0.4531
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0031	0.0022	0.4531
Echinococcus multilocularis	tyrosine protein kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	hypothetical protein	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0031	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0042	0.0049	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosin kinase, putative	0.0031	0.0022	0.4531
Echinococcus multilocularis	activated cdc42 kinase 1	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0031	0.0022	0.0022
Brugia malayi	Tyrosine-protein kinase abl-1	0.0031	0.0022	0.0022
Plasmodium falciparum	protein kinase, putative	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0031	0.0022	1
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Brugia malayi	SH2 domain containing protein	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Entamoeba histolytica	protein kinase, putative	0.0031	0.0022	0.4531
Echinococcus granulosus	tyrosine protein kinase Blk	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0031	0.0022	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0031	0.0022	0.0022
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0071	0.0119	0.0119
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Entamoeba histolytica	tyrosine kinase, putative	0.0031	0.0022	0.4531
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0031	0.0022	0.0022
Echinococcus granulosus	tyrosine kinase	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0031	0.0022	0.1856
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0031	0.0022	0.0022
Trypanosoma brucei	protein kinase, putative	0.0031	0.0022	1
Entamoeba histolytica	hypothetical protein	0.0031	0.0022	0.4531
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0031	0.0022	0.0022
Toxoplasma gondii	protein kinase	0.0031	0.0022	0.1856
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0022	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0031	0.0022	0.0022
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0031	0.0022	0.0022
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0031	0.0022	0.1856
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Entamoeba histolytica	tyrosin kinase, putative	0.0031	0.0022	0.4531
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Echinococcus granulosus	c src tyrosine kinase	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0031	0.0022	0.0022
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0119	1
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0031	0.0022	0.0022
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0022	0.0022
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0031	0.0022	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 25 %	Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as maximal stimulation of cMAP level by cell-based cAMP assay relative to 21	ChEMBL.	21536438
Activity (functional)	= 53 %	Agonist activity at human GPR119 expressed in HEK293 cells assessed as maximal stimulation of cMAP level by cell-based cAMP assay relative to 21	ChEMBL.	21536438
EC50 (functional)	= 131 nM	Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cMAP level by cell-based cAMP assay	ChEMBL.	21536438
EC50 (functional)	= 324 nM	Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as stimulation of cMAP level by cell-based cAMP assay	ChEMBL.	21536438

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3084366

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1818476