TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 389.473 | Formula: C21H19N5OS
H donors: 1 H acceptors: 4 LogP: 3.52 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1sc(nc1C)c1nnn(c1)Cc1ccccc1)NCc1ccccc1
InChi: 1S/C21H19N5OS/c1-15-19(20(27)22-12-16-8-4-2-5-9-16)28-21(23-15)18-14-26(25-24-18)13-17-10-6-3-7-11-17/h2-11,14H,12-13H2,1H3,(H,22,27)
InChiKey: FNRATZPGWXUVAU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	stearoyl-Coenzyme A desaturase 1	Starlite/ChEMBL	References
Homo sapiens	stearoyl-CoA desaturase (delta-9-desaturase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Loa Loa (eye worm)	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium knowlesi	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium berghei	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium falciparum	stearoyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Brugia malayi	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma congolense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	stearic acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Neospora caninum	fatty acyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium yoelii	delta-9 fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0335	1	0.5
Entamoeba histolytica	hypothetical protein	0.0335	1	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	serine/threonine RGC	0.0335	1	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine kinase	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0335	1	0.5
Echinococcus granulosus	tyrosine kinase	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Entamoeba histolytica	hypothetical protein	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0335	1	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0335	1	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Brugia malayi	Raf kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0335	1	0.5
Echinococcus multilocularis	protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0335	1	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0335	1	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0335	1	0.5
Schistosoma mansoni	protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0335	1	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0335	1	0.5
Echinococcus multilocularis	insulin receptor	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Leishmania major	protein kinase, putative	0.0335	1	1
Onchocerca volvulus		0.0335	1	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0335	1	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Plasmodium falciparum	protein kinase, putative	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0335	1	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0335	1	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0335	1	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0335	1	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Loa Loa (eye worm)	TK protein kinase	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0335	1	0.5
Brugia malayi	hypothetical protein	0.0335	1	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0335	1	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine kinase	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Schistosoma mansoni	protein kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0335	1	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0335	1	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Giardia lamblia	Kinase, NEK	0.0335	1	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0335	1	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0335	1	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0335	1	0.5
Echinococcus granulosus	protein kinase	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0335	1	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0335	1	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Schistosoma mansoni	ephrin receptor	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0335	1	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0335	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0335	1	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0335	1	0.5
Toxoplasma gondii	STE kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0335	1	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0335	1	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0335	1	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0335	1	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0335	1	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Entamoeba histolytica	hypothetical protein	0.0335	1	0.5
Echinococcus multilocularis	activin receptor type	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0335	1	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0335	1	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0335	1	0.5
Echinococcus multilocularis	protein kinase	0.0335	1	0.5
Brugia malayi	SH2 domain containing protein	0.0335	1	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus multilocularis	heat shock protein 70	0.0335	1	0.5
Brugia malayi	SH2 domain containing protein	0.0335	1	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0335	1	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0335	1	0.5
Entamoeba histolytica	hypothetical protein	0.0335	1	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0335	1	0.5
Loa Loa (eye worm)	SRC-1	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Trypanosoma brucei	protein kinase, putative	0.0335	1	1
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Entamoeba histolytica	hypothetical protein	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Trypanosoma cruzi	protein kinase, putative	0.0335	1	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Brugia malayi	hypothetical protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Entamoeba histolytica	hypothetical protein	0.0335	1	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK protein kinase	0.0335	1	0.5
Schistosoma mansoni	protein kinase	0.0335	1	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0335	1	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0335	1	0.5
Schistosoma mansoni	protein kinase	0.0335	1	0.5
Brugia malayi	hypothetical protein	0.0335	1	0.5
Brugia malayi	protein-tyrosine kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0335	1	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0335	1	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0335	1	0.5
Echinococcus granulosus	tyrosine kinase	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0335	1	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0335	1	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0335	1	0.5
Schistosoma mansoni	protein kinase	0.0335	1	0.5
Schistosoma mansoni	ephrin receptor	0.0335	1	0.5
Loa Loa (eye worm)	TK/Met protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Trichomonas vaginalis	TK family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0335	1	0.5
Brugia malayi	Receptor family ligand binding region containing protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0335	1	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Plasmodium vivax	protein kinase, putative	0.0335	1	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Trichomonas vaginalis	STE family protein kinase	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0335	1	0.5
Plasmodium falciparum	protein kinase, putative	0.0335	1	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Loa Loa (eye worm)	TK protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus granulosus	tyrosine kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0335	1	0.5
Toxoplasma gondii	protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Trypanosoma cruzi	protein kinase, putative	0.0335	1	1
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0335	1	1
Echinococcus multilocularis	protein tyrosine kinase	0.0335	1	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0335	1	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0335	1	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0335	1	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0335	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Echinococcus granulosus	insulin receptor	0.0335	1	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0335	1	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Leishmania major	hypothetical protein, conserved	0.0335	1	1
Loa Loa (eye worm)	TK protein kinase	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0335	1	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0335	1	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0335	1	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus granulosus	protein tyrosine kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	protein kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0335	1	0.5
Schistosoma mansoni	protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0335	1	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0335	1	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Entamoeba histolytica	hypothetical protein	0.0335	1	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0335	1	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0335	1	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0335	1	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Leishmania major	protein kinase, putative	0.0335	1	1
Onchocerca volvulus		0.0335	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0335	1	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0335	1	0.5
Schistosoma mansoni	protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0335	1	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0335	1	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0335	1	1
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Giardia lamblia	Protein 21.1	0.0335	1	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Schistosoma mansoni	protein kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0335	1	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0335	1	1
Giardia lamblia	Kinase	0.0335	1	0.5
Loa Loa (eye worm)	TK protein kinase	0.0335	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	1	0.5
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0335	1	1
Schistosoma mansoni	protein kinase	0.0335	1	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0335	1	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0335	1	1
Entamoeba histolytica	hypothetical protein	0.0335	1	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0335	1	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0335	1	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0335	1	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0335	1	0.5
Brugia malayi	integrin-linked kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0335	1	0.5
Loa Loa (eye worm)	TK protein kinase	0.0335	1	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0335	1	0.5
Echinococcus multilocularis	activated cdc42 kinase 1	0.0335	1	0.5
Loa Loa (eye worm)	TK protein kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Entamoeba histolytica	hypothetical protein	0.0335	1	0.5
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Echinococcus multilocularis	tyrosine protein kinase	0.0335	1	0.5
Schistosoma mansoni	hypothetical protein	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0335	1	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0335	1	0.5
Loa Loa (eye worm)	TK protein kinase	0.0335	1	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Entamoeba histolytica	hypothetical protein	0.0335	1	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0335	1	1
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Entamoeba histolytica	hypothetical protein	0.0335	1	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0335	1	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0335	1	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Onchocerca volvulus		0.0335	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0335	1	0.5
Giardia lamblia	Kinase, NEK	0.0335	1	0.5
Echinococcus granulosus	activin receptor type	0.0335	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0335	1	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0335	1	1
Brugia malayi	SRC-1	0.0335	1	0.5
Schistosoma mansoni	tyrosine kinase	0.0335	1	0.5
Entamoeba histolytica	protein kinase, putative	0.0335	1	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0335	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0335	1	0.5
Plasmodium falciparum	protein kinase, putative	0.0335	1	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 33 nM	Inhibition of SCD1 in mouse liver microsomes	ChEMBL.	24374272
IC50 (binding)	= 9983 nM	Inhibition of SCD1 in human HepG2 cells using [1-14C]stearic acid as substrate	ChEMBL.	24374272
Inhibition (binding)		Inhibition of human delta-6 desaturase at 10 uM	ChEMBL.	24374272
Inhibition (binding)		Inhibition of human delta-5 desaturase at 10 uM	ChEMBL.	24374272

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3104613

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1820147