Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 13 | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase 11 | References | |
Homo sapiens | mitogen-activated protein kinase 14 | References | |
Homo sapiens | mitogen-activated protein kinase 8 | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase 10 | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase 12 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 11 | 364 aa | 361 aa | 33.0 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 12 | 357 aa | 362 aa | 30.1 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 13 | 365 aa | 366 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0458 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.1166 | 1 | 0.5 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0458 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0559 | 0.1427 | 0.1427 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.1069 | 0.8627 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0458 | 0 | 0.5 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0559 | 0.1427 | 1 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.1166 | 1 | 0.5 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0559 | 0.1427 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0458 | 0 | 0.5 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0559 | 0.1427 | 1 |
Schistosoma mansoni | d-amino acid oxidase | 0.1166 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.013 uM | Inhibition of JNK1 (unknown origin) | ChEMBL. | 24332487 |
IC50 (binding) | = 0.016 uM | Inhibition of JNK3 (39 to 402 amino acids) (unknown origin) expressed in Escherichia coli BL21(DE3) using biotinylated ATF2 as substrate after 15 mins by HTRF assay | ChEMBL. | 24332487 |
IC50 (binding) | = 5.37 uM | Inhibition of p38 (unknown origin) | ChEMBL. | 24332487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.