Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Starlite/ChEMBL | References |
Mus musculus | stearoyl-Coenzyme A desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0018 | 0.0127 | 0.05 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Onchocerca volvulus | 0.0223 | 0.2539 | 1 | |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0205 | 0.2327 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Leishmania major | delta-6 fatty acid desaturase | 0.0018 | 0.0127 | 0.05 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0018 | 0.0127 | 0.5 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0018 | 0.0127 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0223 | 0.2539 | 1 |
Leishmania major | delta-12 fatty acid desaturase | 0.0018 | 0.0127 | 0.05 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0018 | 0.0127 | 0.05 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Leishmania major | stearic acid desaturase, putative | 0.0223 | 0.2539 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0018 | 0.0127 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0018 | 0.0127 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0205 | 0.2327 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0018 | 0.0127 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0205 | 0.2327 | 0.9163 |
Brugia malayi | acyl-CoA desaturase | 0.0205 | 0.2327 | 1 |
Onchocerca volvulus | 0.0223 | 0.2539 | 1 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0205 | 0.2327 | 0.9163 |
Leishmania major | fatty acid desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0205 | 0.2327 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0856 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0855 | 0.9996 | 0.9996 |
Entamoeba histolytica | protein kinase, putative | 0.0856 | 1 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.0223 | 0.2539 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0856 | 1 | 1 |
Leishmania major | delta-4 fatty acid desaturase | 0.0018 | 0.0127 | 0.05 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0018 | 0.0127 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0018 | 0.0127 | 0.5 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0018 | 0.0127 | 0.5 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Leishmania major | fatty acid desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Leishmania major | delta-5 fatty acid desaturase | 0.0018 | 0.0127 | 0.05 |
Mycobacterium ulcerans | hypothetical protein | 0.0018 | 0.0127 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0856 | 1 | 1 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0855 | 0.9996 | 0.9996 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0018 | 0.0127 | 0.5 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0018 | 0.0127 | 0.05 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0223 | 0.2539 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0018 | 0.0127 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0018 | 0.0127 | 0.05 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 63 nM | Inhibition of SCD1 in mouse liver microsomes | ChEMBL. | 24374272 |
IC50 (binding) | = 219 nM | Inhibition of SCD1 in human HepG2 cells using [1-14C]stearic acid as substrate | ChEMBL. | 24374272 |
Inhibition (binding) | Inhibition of human delta-6 desaturase at 10 uM | ChEMBL. | 24374272 | |
Inhibition (binding) | Inhibition of human delta-5 desaturase at 10 uM | ChEMBL. | 24374272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.