Detailed information for compound 182324

Basic information

Technical information
  • TDR Targets ID: 182324
  • Name: 6,7-bis(4-chlorophenyl)-1-ethyl-2,2-dioxopyra zino[2,3-c][1,2,6]thiadiazin-4-amine
  • MW: 448.326 | Formula: C19H15Cl2N5O2S
  • H donors: 1 H acceptors: 4 LogP: 3.46 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1c2nc(c3ccc(cc3)Cl)c(nc2C(=NS1(=O)=O)N)c1ccc(cc1)Cl
  • InChi: 1S/C19H15Cl2N5O2S/c1-2-26-19-17(18(22)25-29(26,27)28)23-15(11-3-7-13(20)8-4-11)16(24-19)12-5-9-14(21)10-6-12/h3-10H,2H2,1H3,(H2,22,25)
  • InChiKey: SIWMLXXCWWCYTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6,7-bis(4-chlorophenyl)-1-ethyl-2,2-dioxo-pyrazino[2,3-c][1,2,6]thiadiazin-4-amine
  • 6,7-bis(4-chlorophenyl)-1-ethyl-2,2-dioxo-4-pyrazino[2,3-c][1,2,6]thiadiazinamine
  • [6,7-bis(4-chlorophenyl)-1-ethyl-2,2-diketo-pyrazino[2,3-c][1,2,6]thiadiazin-4-yl]amine
  • 6,7-bis(4-chlorophenyl)-1-ethyl-2,2-dioxopyrazino[2,3-d][1,2,6]thiadiazin-4-amine
  • 6,7-bis(4-chlorophenyl)-1-ethyl-2,2-dioxo-pyrazino[2,3-d][1,2,6]thiadiazin-4-amine
  • 6,7-bis(4-chlorophenyl)-1-ethyl-2,2-dioxo-4-pyrazino[2,3-d][1,2,6]thiadiazinamine
  • [6,7-bis(4-chlorophenyl)-1-ethyl-2,2-diketo-pyrazino[2,3-d][1,2,6]thiadiazin-4-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0089 0.0043 0.0065
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0173 0.0174 0.026
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0135 0.0114 0.0215
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Echinococcus multilocularis neuropeptides capa receptor 0.0251 0.0295 0.0565
Onchocerca volvulus 0.0251 0.0295 0.1532
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0251 0.0295 0.0444
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0089 0.0043 0.0061
Brugia malayi SEA domain containing protein 0.0218 0.0243 0.0365
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0173 0.0174 0.0171
Loa Loa (eye worm) hypothetical protein 0.0087 0.004 0.0061
Echinococcus multilocularis sex peptide receptor 0.0251 0.0295 0.0565
Schistosoma mansoni cercarial elastase (S01 family) 0.0203 0.0221 0.0218
Loa Loa (eye worm) G-protein coupled receptor 0.0251 0.0295 0.0448
Brugia malayi G-protein coupled receptor 0.0251 0.0295 0.0444
Onchocerca volvulus 0.02 0.0216 0.1117
Echinococcus granulosus nAChR subunit 0.0089 0.0043 0.0077
Brugia malayi PAN domain containing protein 0.02 0.0216 0.0324
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0173 0.0174 0.0331
Brugia malayi Cation transporter family protein 0.0173 0.0174 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0075 0.0021 0.0031
Toxoplasma gondii PAN domain-containing protein 0.2221 0.3361 1
Brugia malayi Kelch motif family protein 0.0735 0.1048 0.1588
Brugia malayi PAN domain containing protein 0.02 0.0216 0.0324
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0173 0.0174 0.026
Echinococcus multilocularis neuropeptide receptor 0.0251 0.0295 0.0565
Schistosoma mansoni biogenic amine receptor 0.0251 0.0295 0.0292
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0251 0.0295 0.0565
Brugia malayi Cation transporter family protein 0.0173 0.0174 0.026
Schistosoma mansoni cercarial elastase (S01 family) 0.0203 0.0221 0.0218
Schistosoma mansoni nAChR subunit 0.0084 0.0036 0.0033
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0173 0.0174 0.0331
Loa Loa (eye worm) hypothetical protein 0.0089 0.0043 0.0065
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Brugia malayi hypothetical protein 0.0251 0.0295 0.0444
Loa Loa (eye worm) ACC-1 protein 0.0173 0.0174 0.0264
Brugia malayi Protein kinase domain containing protein 0.0329 0.0417 0.063
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Echinococcus granulosus voltage dependent calcium channel 0.0135 0.0114 0.0215
Echinococcus multilocularis g protein coupled receptor 0.0251 0.0295 0.0565
Echinococcus granulosus integrin beta 2 0.3388 0.5177 1
Toxoplasma gondii microneme protein MIC4 0.02 0.0216 0.0358
Brugia malayi EGF-like domain containing protein 0.0125 0.0099 0.0146
Loa Loa (eye worm) hypothetical protein 0.0125 0.0099 0.015
Onchocerca volvulus 0.0251 0.0295 0.1532
Schistosoma mansoni voltage-gated cation channel 0.0135 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0735 0.1048 0.1591
Loa Loa (eye worm) neuropeptide F receptor 0.0251 0.0295 0.0448
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0251 0.0295 0.0444
Schistosoma mansoni hypothetical protein 0.0218 0.0243 0.0241
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Brugia malayi sulfakinin receptor protein 0.0251 0.0295 0.0444
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.02 0.0216 0.0328
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0682 0.0966 0.1464
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Brugia malayi hypothetical protein 0.0084 0.0036 0.005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0203 0.0221 0.0218
Toxoplasma gondii PAN domain-containing protein 0.02 0.0216 0.0358
Schistosoma mansoni integrin alpha 0.117 0.1725 0.1723
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.0148 0.0281
Echinococcus granulosus kelch ECH associated protein 1 like 0.0095 0.0053 0.0097
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0173 0.0174 0.0171
Echinococcus granulosus glycoprotein Antigen 5 0.0203 0.0221 0.0422
Brugia malayi hypothetical protein 0.0084 0.0036 0.005
Schistosoma mansoni neuropeptide F-like receptor 0.0251 0.0295 0.0292
Schistosoma mansoni hypothetical protein 0.0087 0.004 0.0038
Schistosoma mansoni amine GPCR 0.0251 0.0295 0.0292
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.0174 0.026
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0084 0.0036 0.0064
Brugia malayi ORL1-like opioid receptor 0.0251 0.0295 0.0444
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0251 0.0295 0.0448
Schistosoma mansoni serine-type protease inhibitor 0.6488 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0251 0.0295 0.0292
Brugia malayi PAN domain containing protein 0.02 0.0216 0.0324
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0295 0.0292
Brugia malayi Melatonin receptor type 1A 0.0251 0.0295 0.0444
Echinococcus granulosus kelch ECH associated protein 1 0.0095 0.0053 0.0097
Onchocerca volvulus 0.0251 0.0295 0.1532
Schistosoma mansoni tyrosine kinase 0.0156 0.0148 0.0145
Loa Loa (eye worm) hypothetical protein 0.02 0.0216 0.0328
Echinococcus multilocularis G-protein coupled receptor, putative 0.0251 0.0295 0.0565
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.0036 0.005
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Echinococcus multilocularis receptor type guanylyl cyclase 0.0216 0.024 0.0459
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Brugia malayi G protein-coupled receptor F59B2.13 0.0251 0.0295 0.0444
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0173 0.0174 0.0331
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0135 0.0114 0.0215
Loa Loa (eye worm) hypothetical protein 0.0689 0.0976 0.1483
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0173 0.0174 0.026
Loa Loa (eye worm) hypothetical protein 0.0063 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Loa Loa (eye worm) hypothetical protein 0.1289 0.191 0.29
Echinococcus granulosus Mastin 0.0203 0.0221 0.0422
Echinococcus granulosus atrial natriuretic peptide receptor 0.019 0.0199 0.038
Echinococcus multilocularis serotonin receptor 0.0251 0.0295 0.0565
Brugia malayi AKH receptor 0.0251 0.0295 0.0444
Onchocerca volvulus 0.0084 0.0036 0.0173
Loa Loa (eye worm) hypothetical protein 0.0063 0.0003 0.0004
Echinococcus multilocularis allatostatin A receptor 0.0251 0.0295 0.0565
Brugia malayi hypothetical protein 0.0203 0.0221 0.0331
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Loa Loa (eye worm) RGC/RGC protein kinase 0.0216 0.024 0.0365
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0173 0.0174 0.026
Echinococcus multilocularis fibrillin 2 0.0125 0.0099 0.0186
Schistosoma mansoni cercarial elastase (S01 family) 0.0203 0.0221 0.0218
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0251 0.0295 0.0448
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.0036 0.005
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0084 0.0036 0.0064
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Echinococcus multilocularis transmembrane protease serine 3 0.0203 0.0221 0.0422
Echinococcus multilocularis nAChR subunit 0.0089 0.0043 0.0077
Echinococcus granulosus tm gpcr rhodopsin 0.0251 0.0295 0.0565
Brugia malayi Trypsin-like protease protein 5 0.0203 0.0221 0.0331
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Echinococcus multilocularis voltage dependent calcium channel 0.0135 0.0114 0.0215
Mycobacterium ulcerans hypothetical protein 0.0203 0.0221 1
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0173 0.0174 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0173 0.0174 0.026
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0689 0.0976 0.0974
Echinococcus multilocularis fmrfamide receptor 0.0251 0.0295 0.0565
Brugia malayi jmjC domain containing protein 0.0097 0.0056 0.0081
Toxoplasma gondii subtilisin SUB12 0.02 0.0216 0.0358
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Schistosoma mansoni cercarial elastase (S01 family) 0.0203 0.0221 0.0218
Echinococcus granulosus potassium voltage gated channel protein 0.0541 0.0746 0.1436
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0541 0.0746 0.1129
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Onchocerca volvulus 0.0251 0.0295 0.1532
Giardia lamblia Neurogenic locus notch-like protein 0.0125 0.0099 0.5
Brugia malayi RE15519p 0.0251 0.0295 0.0444
Echinococcus granulosus orexin receptor type 2 0.0251 0.0295 0.0565
Loa Loa (eye worm) TK/ROR protein kinase 0.0329 0.0417 0.0634
Onchocerca volvulus 0.0089 0.0043 0.021
Echinococcus granulosus glycine receptor subunit beta 0.0173 0.0174 0.0331
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.0295 0.0448
Giardia lamblia Tenascin precursor 0.0125 0.0099 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0203 0.0221 0.0218
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Schistosoma mansoni neurotransmitter gated ion channel 0.0084 0.0036 0.0033
Loa Loa (eye worm) apoptosis regulator protein 0.0087 0.004 0.0061
Echinococcus granulosus integrin alpha ps 0.0298 0.0369 0.0708
Brugia malayi PAN domain containing protein 0.02 0.0216 0.0324
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0092 0.0048 0.112
Schistosoma mansoni hypothetical protein 0.0251 0.0295 0.0292
Echinococcus multilocularis g-protein coupled receptor 0.0251 0.0295 0.0565
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0173 0.0174 0.0331
Brugia malayi putative neuropeptide receptor NPR1 0.0251 0.0295 0.0444
Loa Loa (eye worm) GABA receptor subunit 0.0089 0.0043 0.0065
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Loa Loa (eye worm) DOMON domain-containing protein 0.0218 0.0243 0.0369
Echinococcus multilocularis kelch ECH associated protein 1 0.0095 0.0053 0.0097
Schistosoma mansoni hypothetical protein 0.0251 0.0295 0.0292
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0092 0.0048 0.5
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0173 0.0174 0.0331
Brugia malayi Dopamine receptor 0.0251 0.0295 0.0444
Echinococcus granulosus tm gpcr rhodopsin 0.0251 0.0295 0.0565
Brugia malayi Kringle domain containing protein 0.0321 0.0404 0.061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0295 0.0292
Brugia malayi Serotonin receptor 0.0251 0.0295 0.0444
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0173 0.0174 0.0331
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0251 0.0295 0.0565
Brugia malayi hypothetical protein 0.0251 0.0295 0.0444
Schistosoma mansoni cercarial elastase (S01 family) 0.0203 0.0221 0.0218
Onchocerca volvulus 0.0203 0.0221 0.1144
Brugia malayi Muscle positioning protein 4 0.0222 0.025 0.0375
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0084 0.0036 0.0054
Brugia malayi hypothetical protein 0.0251 0.0295 0.0444
Schistosoma mansoni hypothetical protein 0.0251 0.0295 0.0292
Echinococcus granulosus biogenic amine 5HT receptor 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0173 0.0174 0.0264
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Brugia malayi larval opioid receptor 0.0251 0.0295 0.0444
Echinococcus granulosus sex peptide receptor 0.0251 0.0295 0.0565
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0173 0.0174 0.026
Echinococcus multilocularis glycine receptor subunit beta 0.0173 0.0174 0.0331
Loa Loa (eye worm) hypothetical protein 0.02 0.0216 0.0328
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0295 0.0292
Echinococcus multilocularis somatostatin receptor 0.0251 0.0295 0.0565
Brugia malayi Trypsin family protein 0.0203 0.0221 0.0331
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0063 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Loa Loa (eye worm) hypothetical protein 0.0089 0.0043 0.0065
Brugia malayi Integrin alpha pat-2 precursor 0.117 0.1725 0.2617
Schistosoma mansoni nAChR subunit 0.0173 0.0174 0.0171
Schistosoma mansoni cercarial elastase (S01 family) 0.0203 0.0221 0.0218
Echinococcus granulosus integrin alpha 3 0.0846 0.1221 0.2354
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0084 0.0036 0.0054
Schistosoma mansoni hypothetical protein 0.0298 0.0369 0.0366
Onchocerca volvulus 0.0689 0.0976 0.5106
Echinococcus granulosus neuropeptide Y receptor 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0547 0.0756 0.1149
Schistosoma mansoni hypothetical protein 0.0251 0.0295 0.0292
Schistosoma mansoni tyrosine kinase 0.0079 0.0028 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Brugia malayi G-protein coupled receptor 0.0251 0.0295 0.0444
Schistosoma mansoni opsin-like receptor 0.0251 0.0295 0.0292
Onchocerca volvulus 0.1289 0.191 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0216 0.024 0.0365
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0173 0.0174 0.026
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Toxoplasma gondii hypothetical protein 0.02 0.0216 0.0358
Loa Loa (eye worm) hypothetical protein 0.0063 0.0003 0.0004
Brugia malayi GnHR receptor homolog 0.0251 0.0295 0.0444
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0251 0.0295 0.0565
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0203 0.0221 0.0218
Echinococcus multilocularis integrin alpha ps 0.0623 0.0874 0.1683
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0203 0.0221 0.0331
Brugia malayi Receptor family ligand binding region containing protein 0.0216 0.024 0.0361
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0135 0.0114 0.0215
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0135 0.0114 0.0215
Loa Loa (eye worm) hypothetical protein 0.0605 0.0845 0.1284
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Schistosoma mansoni histamine h1 receptor 0.0251 0.0295 0.0292
Schistosoma mansoni adenoreceptor 0.0251 0.0295 0.0292
Toxoplasma gondii kringle domain-containing protein 0.0321 0.0404 0.0936
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0153 0.0143 0.0271
Loa Loa (eye worm) PAN domain-containing protein 0.02 0.0216 0.0328
Brugia malayi hypothetical protein 0.0251 0.0295 0.0444
Echinococcus granulosus 7tm_1 domain containing protein 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Schistosoma mansoni tyrosine kinase 0.0079 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Brugia malayi neuropeptide F receptor 0.0251 0.0295 0.0444
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0173 0.0174 0.0331
Brugia malayi Tachykinin-like peptides receptor 99D 0.0251 0.0295 0.0444
Schistosoma mansoni acetylcholine receptor-related 0.0084 0.0036 0.0033
Onchocerca volvulus 0.0251 0.0295 0.1532
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.0036 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0321 0.0404 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0173 0.0174 0.0171
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.0174 0.026
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0203 0.0221 0.0422
Schistosoma mansoni neuropeptide receptor 0.0251 0.0295 0.0292
Onchocerca volvulus 0.0251 0.0295 0.1532
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Schistosoma mansoni neuropeptide receptor 0.0251 0.0295 0.0292
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0203 0.0221 0.0218
Echinococcus granulosus fibrillin 1 0.0125 0.0099 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0125 0.0099 0.015
Brugia malayi Trypsin family protein 0.0203 0.0221 0.0331
Echinococcus multilocularis integrin beta 2 0.3388 0.5177 1
Echinococcus granulosus dro:myosuppressin receptor 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0386 0.0504 0.0766
Loa Loa (eye worm) hypothetical protein 0.0071 0.0016 0.0024
Echinococcus granulosus neuropeptide receptor 0.0401 0.0528 0.1015
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0084 0.0036 0.0064
Echinococcus granulosus g protein coupled receptor 0.0251 0.0295 0.0565
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0173 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0541 0.0746 0.1132
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0135 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.0682 0.0966 0.1467
Onchocerca volvulus 0.0125 0.0099 0.0505
Onchocerca volvulus 0.0222 0.025 0.1296
Schistosoma mansoni biogenic amine receptor 0.0251 0.0295 0.0292
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0251 0.0295 0.0292
Schistosoma mansoni nAChR subunit 0.0173 0.0174 0.0171
Onchocerca volvulus 0.02 0.0216 0.1117
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Echinococcus granulosus neuropeptide receptor 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0203 0.0221 0.0335
Schistosoma mansoni tyrosine kinase 0.0088 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Echinococcus granulosus alpha 1A adrenergic receptor 0.0251 0.0295 0.0565
Brugia malayi excitatory GABA receptor EXP-1A 0.0173 0.0174 0.026
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.0174 0.026
Brugia malayi G protein-coupled receptor 0.0251 0.0295 0.0444
Brugia malayi Trypsin family protein 0.1289 0.191 0.2897
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0173 0.0174 0.0331
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.0174 0.026
Schistosoma mansoni hypothetical protein 0.0203 0.0221 0.0218
Echinococcus multilocularis g protein coupled receptor 0.0251 0.0295 0.0565
Echinococcus granulosus transmembrane protease serine 3 0.0203 0.0221 0.0422
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0173 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0203 0.0221 0.0422
Brugia malayi hypothetical protein 0.0251 0.0295 0.0444
Schistosoma mansoni tyrosine kinase 0.0079 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Schistosoma mansoni amine GPCR 0.0251 0.0295 0.0292
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0251 0.0295 0.0292
Echinococcus granulosus fibrillin 2 0.0125 0.0099 0.0186
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Brugia malayi hypothetical protein 0.0084 0.0036 0.005
Toxoplasma gondii microneme protein MIC17B 0.02 0.0216 0.0358
Onchocerca volvulus 0.0689 0.0976 0.5106
Schistosoma mansoni hypothetical protein 0.0087 0.004 0.0038
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0089 0.0043 0.0061
Onchocerca volvulus Putative nachr subunit 0.0173 0.0174 0.0897
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0251 0.0295 0.0565
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0251 0.0295 0.0292
Toxoplasma gondii microneme protein MIC17A 0.02 0.0216 0.0358
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0135 0.0114 0.0169
Brugia malayi hypothetical protein 0.0251 0.0295 0.0444
Brugia malayi PAN domain containing protein 0.02 0.0216 0.0324
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Echinococcus multilocularis epidermal growth factor receptor 0.0088 0.0041 0.0074
Echinococcus multilocularis Mastin 0.0203 0.0221 0.0422
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0251 0.0295 0.0565
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0088 0.0041 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0295 0.0292
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.0174 0.026
Toxoplasma gondii PAN domain-containing protein 0.2221 0.3361 1
Onchocerca volvulus 0.0218 0.0243 0.1262
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0203 0.0221 0.0218
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0135 0.0114 0.0111
Loa Loa (eye worm) PAN domain-containing protein 0.02 0.0216 0.0328
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0295 0.0292
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0173 0.0174 0.0331
Onchocerca volvulus 0.02 0.0216 0.1117
Schistosoma mansoni nAChR subunit 0.0084 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0063 0.0003 0.0004
Brugia malayi PAN domain containing protein 0.02 0.0216 0.0324
Echinococcus granulosus peptide allatostatin:somatostatin 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0173 0.0174 0.0331
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0517 0.071 0.1366
Brugia malayi hypothetical protein 0.0251 0.0295 0.0444
Onchocerca volvulus 0.0218 0.0243 0.1262
Loa Loa (eye worm) hypothetical protein 0.0203 0.0221 0.0335
Echinococcus multilocularis nAChR subunit 0.0173 0.0174 0.0331
Loa Loa (eye worm) hypothetical protein 0.0075 0.0021 0.0031
Onchocerca volvulus 0.02 0.0216 0.1117
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0089 0.0043 0.004
Echinococcus granulosus neuropeptide receptor A26 0.0251 0.0295 0.0565
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0251 0.0295 0.0565
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0321 0.0404 0.5
Echinococcus multilocularis kelch ECH associated protein 1 0.0095 0.0053 0.0097
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1289 0.191 0.1908
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Echinococcus granulosus integrin alpha ps 0.0684 0.0969 0.1867
Echinococcus multilocularis glycine receptor subunit beta 0.0173 0.0174 0.0331
Schistosoma mansoni amine GPCR 0.0251 0.0295 0.0292
Echinococcus multilocularis tissue type plasminogen activator 0.0321 0.0404 0.0776
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0173 0.0174 0.0331
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0173 0.0174 0.026
Echinococcus granulosus kelch ECH associated protein 1 like 0.0095 0.0053 0.0097
Brugia malayi Integrin beta pat-3 precursor 0.4294 0.6586 1
Onchocerca volvulus 0.0203 0.0221 0.1144
Schistosoma mansoni cercarial elastase (S01 family) 0.0203 0.0221 0.0218
Brugia malayi PAN domain containing protein 0.02 0.0216 0.0324
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0251 0.0295 0.0444
Schistosoma mansoni integrin alpha-4 0.0382 0.0499 0.0497
Schistosoma mansoni nAChR subunit 0.0173 0.0174 0.0171
Schistosoma mansoni acetylcholine receptor subunit beta 0.0084 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0125 0.0099 0.015
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0251 0.0295 0.0292
Schistosoma mansoni voltage-gated potassium channel 0.0541 0.0746 0.0743
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0251 0.0295 0.0292
Schistosoma mansoni myosin xvIII 0.0251 0.0295 0.0292
Toxoplasma gondii 1,3(4)-beta-glucanase 0.02 0.0216 0.0358
Entamoeba histolytica hypothetical protein 0.0089 0.0043 1
Echinococcus multilocularis neuropeptide receptor A26 0.0251 0.0295 0.0565
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0251 0.0295 0.0565
Schistosoma mansoni opsin-like receptor 0.0251 0.0295 0.0292
Echinococcus multilocularis potassium voltage gated channel protein 0.0541 0.0746 0.1436
Echinococcus multilocularis voltage dependent calcium channel 0.0135 0.0114 0.0215
Echinococcus multilocularis dro:myosuppressin receptor 0.0251 0.0295 0.0565
Echinococcus granulosus G protein coupled receptor 139 0.0251 0.0295 0.0565
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0251 0.0295 0.0565
Echinococcus granulosus tm gpcr rhodopsin 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Echinococcus multilocularis enteropeptidase 0.0203 0.0221 0.0422
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0251 0.0295 0.0565
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0135 0.0114 0.0215
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0084 0.0036 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0295 0.0292
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0251 0.0295 0.0448
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0025 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Echinococcus granulosus biogenic amine 5HT receptor 0.0251 0.0295 0.0565
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Onchocerca volvulus 0.0084 0.0036 0.0173
Echinococcus multilocularis integrin alpha 3 0.0846 0.1221 0.2354
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0203 0.0221 0.0335
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Schistosoma mansoni neuropeptide f receptor 76f 0.0251 0.0295 0.0292
Echinococcus multilocularis adam 0.0125 0.0099 0.0186
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0203 0.0221 0.0422
Echinococcus multilocularis Kelch repeat type 1 0.0095 0.0053 0.0098
Schistosoma mansoni integrin alpha-ps 0.0386 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0173 0.0174 0.026
Onchocerca volvulus 0.02 0.0216 0.1117
Onchocerca volvulus 0.0089 0.0043 0.0214
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Echinococcus granulosus serotonin receptor 0.0251 0.0295 0.0565
Echinococcus granulosus tachykinin peptides receptor 99D 0.0251 0.0295 0.0565
Loa Loa (eye worm) glutamate receptor 0.0063 0.0003 0.0004
Brugia malayi hypothetical protein 0.0251 0.0295 0.0444
Onchocerca volvulus 0.02 0.0216 0.1117
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Onchocerca volvulus 0.0251 0.0295 0.1532
Schistosoma mansoni neuropeptide receptor 0.0401 0.0528 0.0525
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Schistosoma mansoni neurotransmitter gated ion channel 0.0089 0.0043 0.004
Echinococcus multilocularis G protein coupled receptor 139 0.0401 0.0528 0.1015
Giardia lamblia High cysteine protein 0.0125 0.0099 0.5
Schistosoma mansoni nAChR subunit 0.0173 0.0174 0.0171
Loa Loa (eye worm) hypothetical protein 0.07 0.0994 0.1509
Giardia lamblia High cysteine protein 0.0125 0.0099 0.5
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0087 0.004 0.0057
Schistosoma mansoni nAChR subunit 0.0173 0.0174 0.0171
Loa Loa (eye worm) hypothetical protein 0.0321 0.0404 0.0614
Loa Loa (eye worm) trypsin family protein 0.0203 0.0221 0.0335
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0251 0.0295 0.0292
Onchocerca volvulus 0.0173 0.0174 0.0897
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Echinococcus granulosus glycine receptor subunit alpha 1 0.0173 0.0174 0.0331
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Onchocerca volvulus 0.0689 0.0976 0.5106
Onchocerca volvulus 0.0089 0.0043 0.021
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0173 0.0174 0.0331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0295 0.0292
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Brugia malayi Cation transporter family protein 0.0689 0.0976 0.1479
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.0148 0.0281
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Brugia malayi PAN domain containing protein 0.02 0.0216 0.0324
Onchocerca volvulus 0.0251 0.0295 0.1532
Echinococcus granulosus tyrosine kinase 0.0071 0.0016 0.0025
Loa Loa (eye worm) hypothetical protein 0.0063 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Brugia malayi PAN domain containing protein 0.02 0.0216 0.0324
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0173 0.0174 0.0331
Schistosoma mansoni hypothetical protein 0.0321 0.0404 0.0402
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0056 0.0103
Brugia malayi Dopamine receptor protein 1 0.0251 0.0295 0.0444
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0251 0.0295 0.0292
Onchocerca volvulus 0.0173 0.0174 0.0897
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0251 0.0295 0.0292
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Echinococcus multilocularis serotonin receptor 0.0251 0.0295 0.0565
Schistosoma mansoni apoptosis regulator bax 0.0087 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Echinococcus granulosus adam 0.0125 0.0099 0.0186
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1363 0.2026 0.2024
Onchocerca volvulus 0.0173 0.0174 0.0897
Echinococcus multilocularis neuropeptide FF receptor 2 0.0251 0.0295 0.0565
Schistosoma mansoni growth hormone secretagogue receptor 0.0251 0.0295 0.0292
Leishmania major hypothetical protein, conserved 0.0321 0.0404 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0251 0.0295 0.0292
Loa Loa (eye worm) hypothetical protein 0.0135 0.0114 0.0173
Echinococcus multilocularis integrin alpha ps 0.0298 0.0369 0.0708
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0251 0.0295 0.0565
Schistosoma mansoni tyrosine kinase 0.0071 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Echinococcus multilocularis integrin alpha ps 0.0684 0.0969 0.1867
Loa Loa (eye worm) hypothetical protein 0.0689 0.0976 0.1483
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Loa Loa (eye worm) PAN domain-containing protein 0.02 0.0216 0.0328
Echinococcus granulosus neuropeptide FF receptor 2 0.0251 0.0295 0.0565
Echinococcus granulosus rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0087 0.004 0.0073
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0238 0.0275 0.0273
Schistosoma mansoni protein kinase 0.0216 0.024 0.0238
Echinococcus multilocularis orexin receptor type 2 0.0251 0.0295 0.0565
Onchocerca volvulus 0.0251 0.0295 0.1532
Schistosoma mansoni neuropeptide F-like receptor 0.0251 0.0295 0.0292
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0125 0.0099 0.5
Onchocerca volvulus 0.0251 0.0295 0.1532
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0173 0.0174 0.0331
Echinococcus multilocularis g protein coupled receptor 0.0251 0.0295 0.0565
Toxoplasma gondii microneme protein MIC17C 0.02 0.0216 0.0358
Brugia malayi hypothetical protein 0.0251 0.0295 0.0444
Brugia malayi hypothetical protein 0.07 0.0994 0.1505
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0056 0.0103
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Schistosoma mansoni amine GPCR 0.0251 0.0295 0.0292
Echinococcus granulosus epidermal growth factor receptor 0.0088 0.0041 0.0074
Schistosoma mansoni biogenic amine (5HT) receptor 0.0251 0.0295 0.0292
Echinococcus multilocularis sodium channel protein 0.0153 0.0143 0.0271
Brugia malayi EGF-like domain containing protein 0.0125 0.0099 0.0146
Onchocerca volvulus 0.0251 0.0295 0.1532
Schistosoma mansoni tyrosine kinase 0.0088 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0063 0.0003 0.0004
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0173 0.0174 0.0331
Schistosoma mansoni opsin-like receptor 0.0251 0.0295 0.0292
Schistosoma mansoni hypothetical protein 0.0203 0.0221 0.0218
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0089 0.0043 0.004
Onchocerca volvulus 0.0218 0.0243 0.1262
Leishmania major calcium channel protein, putative,ion transporter, putative 0.011 0.0075 0.1806
Loa Loa (eye worm) PAN domain-containing protein 0.02 0.0216 0.0328
Schistosoma mansoni cercarial elastase (S01 family) 0.0203 0.0221 0.0218
Echinococcus multilocularis fmrfamide receptor 0.0251 0.0295 0.0565
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0084 0.0036 0.005
Schistosoma mansoni nAChR subunit 0.0173 0.0174 0.0171
Loa Loa (eye worm) calcium channel 0.0135 0.0114 0.0173
Echinococcus multilocularis protein jagged 2 0.0125 0.0099 0.0186
Toxoplasma gondii hypothetical protein 0.02 0.0216 0.0358
Loa Loa (eye worm) TK/EGFR protein kinase 0.0156 0.0148 0.0225
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Echinococcus granulosus neuropeptides capa receptor 0.0251 0.0295 0.0565
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0089 0.0043 0.0061
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Onchocerca volvulus 0.0251 0.0295 0.1532
Trichomonas vaginalis hypothetical protein 0.0125 0.0099 0.5
Schistosoma mansoni integrin alpha-ps 0.0623 0.0874 0.0871
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Loa Loa (eye worm) hypothetical protein 0.02 0.0216 0.0328
Plasmodium falciparum cysteine repeat modular protein 1 0.0321 0.0404 0.5
Onchocerca volvulus 0.0251 0.0295 0.1532
Onchocerca volvulus 0.0203 0.0221 0.1144
Loa Loa (eye worm) hypothetical protein 0.0173 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0218 0.0243 0.0369
Toxoplasma gondii PAN/Apple domain-containing protein 0.02 0.0216 0.0358
Echinococcus granulosus fmrfamide receptor 0.0251 0.0295 0.0565
Brugia malayi Guanylyl cyclase protein 23 0.0089 0.0043 0.0062
Onchocerca volvulus 0.0203 0.0221 0.1144
Onchocerca volvulus 0.02 0.0216 0.1117
Brugia malayi PAN domain containing protein 0.02 0.0216 0.0324
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0084 0.0036 0.005
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0173 0.0174 0.0331
Echinococcus granulosus glycine receptor subunit beta 0.0173 0.0174 0.0331
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0135 0.0114 0.0215
Loa Loa (eye worm) hypothetical protein 0.02 0.0216 0.0328
Schistosoma mansoni tyrosine kinase 0.0071 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.036 0.0464 0.0705
Echinococcus granulosus 7TM GPCR rhodopsin 0.0251 0.0295 0.0565
Brugia malayi hypothetical protein 0.0084 0.0036 0.005
Schistosoma mansoni integrin beta subunit 0.2689 0.4088 0.4086
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0251 0.0295 0.0565
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0251 0.0295 0.0448
Onchocerca volvulus 0.02 0.0216 0.1117
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0087 0.004 0.0073
Schistosoma mansoni hypothetical protein 0.0087 0.004 0.0038
Brugia malayi Furin-like cysteine rich region family protein 0.0156 0.0148 0.0221
Echinococcus granulosus receptor type guanylyl cyclase 0.0216 0.024 0.0459
Echinococcus multilocularis tyrosine kinase 0.0071 0.0016 0.0025
Schistosoma mansoni neurotransmitter gated ion channel 0.0084 0.0036 0.0033
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0203 0.0221 0.0335
Brugia malayi follicle stimulating hormone receptor 0.0251 0.0295 0.0444
Loa Loa (eye worm) PAN domain-containing protein 0.02 0.0216 0.0328
Loa Loa (eye worm) RGC/RGC protein kinase 0.0089 0.0043 0.0066
Loa Loa (eye worm) hypothetical protein 0.0089 0.0043 0.0065
Toxoplasma gondii microneme protein, putative 0.02 0.0216 0.0358
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0084 0.0036 0.0064
Schistosoma mansoni voltage-gated potassium channel 0.0541 0.0746 0.0743
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0063 0.0003 0.0004
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0689 0.0976 0.0974
Loa Loa (eye worm) LGC-31 protein 0.0173 0.0174 0.0264
Loa Loa (eye worm) acetylcholine receptor protein 0.0084 0.0036 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0295 0.0292
Onchocerca volvulus 0.02 0.0216 0.1117
Loa Loa (eye worm) neuropeptide F receptor 0.0251 0.0295 0.0448
Onchocerca volvulus 0.0251 0.0295 0.1532
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0251 0.0295 0.0565
Echinococcus granulosus neuropeptides capa receptor 0.0251 0.0295 0.0565
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0251 0.0295 0.0565
Schistosoma mansoni cercarial elastase (S01 family) 0.0203 0.0221 0.0218
Echinococcus multilocularis neuropeptide Y receptor 0.0251 0.0295 0.0565
Echinococcus granulosus g-protein coupled receptor 0.0251 0.0295 0.0565
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0084 0.0036 0.005
Onchocerca volvulus 0.0251 0.0295 0.1532
Loa Loa (eye worm) ACC-1 protein 0.0173 0.0174 0.0264
Echinococcus granulosus somatostatin receptor 0.0251 0.0295 0.0565
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0541 0.0746 0.1436
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Giardia lamblia Tenascin-X 0.0125 0.0099 0.5
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0063 0.0003 0.0004
Echinococcus multilocularis neuropeptide receptor 0.0401 0.0528 0.1015
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0251 0.0295 0.1532
Echinococcus granulosus neuropeptide Y receptor 0.0251 0.0295 0.0565
Brugia malayi EGF-like domain containing protein 0.0125 0.0099 0.0146
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0251 0.0295 0.0292
Loa Loa (eye worm) hypothetical protein 0.0089 0.0043 0.0065
Brugia malayi Trypsin family protein 0.0203 0.0221 0.0331
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0173 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0087 0.004 0.0073
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0203 0.0221 0.0218
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0087 0.004 0.0073
Echinococcus granulosus hypothetical protein 0.0251 0.0295 0.0565
Brugia malayi putative neuropeptide receptor 0.0251 0.0295 0.0444
Onchocerca volvulus 0.0084 0.0036 0.0173
Schistosoma mansoni nAChR subunit 0.0173 0.0174 0.0171
Brugia malayi Dopamine receptor protein 2 0.0251 0.0295 0.0444
Loa Loa (eye worm) hypothetical protein 0.0063 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0125 0.0099 0.015
Echinococcus granulosus glycine receptor subunit alpha 1 0.0173 0.0174 0.0331
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Onchocerca volvulus 0.0251 0.0295 0.1532
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Giardia lamblia Tenascin-37 0.0125 0.0099 0.5
Loa Loa (eye worm) hypothetical protein 0.1289 0.191 0.29
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0173 0.0174 0.0264
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Echinococcus granulosus neuropeptide s receptor 0.0251 0.0295 0.0565
Schistosoma mansoni biogenic amine (5HT) receptor 0.0251 0.0295 0.0292
Echinococcus granulosus enteropeptidase 0.0203 0.0221 0.0422
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0251 0.0295 0.0565
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0173 0.0174 0.0331
Loa Loa (eye worm) melatonin receptor type 1A 0.0251 0.0295 0.0448
Echinococcus multilocularis fibrillin 1 0.0125 0.0099 0.0186
Schistosoma mansoni hypothetical protein 0.0095 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.0872 0.1261 0.1915
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0203 0.0221 0.0422
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0173 0.0174 0.0331
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0054
Toxoplasma gondii PAN domain-containing protein 0.02 0.0216 0.0358
Echinococcus multilocularis neuropeptide s receptor 0.0251 0.0295 0.0565
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0000064161 0.0000097422
Echinococcus granulosus g protein coupled receptor 0.0251 0.0295 0.0565
Onchocerca volvulus 0.0251 0.0295 0.1532
Schistosoma mansoni cercarial elastase (S01 family) 0.0203 0.0221 0.0218
Loa Loa (eye worm) TYRA-2 protein 0.0251 0.0295 0.0448
Schistosoma mansoni amine GPCR 0.0251 0.0295 0.0292
Giardia lamblia Neurogenic locus Notch protein precursor 0.0125 0.0099 0.5
Schistosoma mansoni neuropeptide receptor 0.0251 0.0295 0.0292
Loa Loa (eye worm) hypothetical protein 0.0089 0.0043 0.0065
Loa Loa (eye worm) integrin alpha pat-2 0.1493 0.2227 0.3382
Echinococcus granulosus glycine receptor subunit alpha 1 0.0173 0.0174 0.0331
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0087 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Onchocerca volvulus 0.1086 0.1594 0.8342
Loa Loa (eye worm) hypothetical protein 0.02 0.0216 0.0328
Giardia lamblia Tenascin-like 0.0125 0.0099 0.5
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0216 0.024 0.1246
Onchocerca volvulus 0.02 0.0216 0.1117
Echinococcus granulosus allatostatin A receptor 0.0251 0.0295 0.0565
Onchocerca volvulus 0.02 0.0216 0.1117
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0203 0.0221 0.0335
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0173 0.0174 0.026
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Brugia malayi hypothetical protein 0.0084 0.0036 0.005
Schistosoma mansoni alpha-1 adrenergic receptor 0.0251 0.0295 0.0292
Loa Loa (eye worm) hypothetical protein 0.0089 0.0043 0.0065
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0135 0.0114 0.0215
Loa Loa (eye worm) hypothetical protein 0.0222 0.025 0.0379
Echinococcus multilocularis glycoprotein Antigen 5 0.0203 0.0221 0.0422
Echinococcus multilocularis neuropeptide Y receptor 0.0251 0.0295 0.0565
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0173 0.0174 0.0264
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0251 0.0295 0.0292
Toxoplasma gondii PAN domain-containing protein 0.02 0.0216 0.0358
Brugia malayi CUB domain containing protein 0.0075 0.0021 0.0027
Brugia malayi EGF-like domain containing protein 0.0125 0.0099 0.0146
Echinococcus granulosus g protein coupled receptor 0.0251 0.0295 0.0565
Brugia malayi Serotonin receptor 0.0251 0.0295 0.0444
Echinococcus multilocularis atrial natriuretic peptide receptor 0.019 0.0199 0.038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0251 0.0295 0.0565
Echinococcus granulosus tissue type plasminogen activator 0.0321 0.0404 0.0776
Echinococcus granulosus sodium channel protein 0.011 0.0075 0.014
Echinococcus multilocularis neuropeptides capa receptor 0.0251 0.0295 0.0565
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0251 0.0295 0.0565
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Onchocerca volvulus 0.0203 0.0221 0.1144
Giardia lamblia hypothetical protein 0.0125 0.0099 0.5
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0251 0.0295 0.0444
Loa Loa (eye worm) hypothetical protein 0.0089 0.0043 0.0065
Brugia malayi hypothetical protein 0.0251 0.0295 0.0444
Loa Loa (eye worm) integrin beta-2 0.4294 0.6586 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0251 0.0295 0.0565
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0089 0.0043 0.0061
Onchocerca volvulus 0.0321 0.0404 0.2105
Echinococcus granulosus nAChR subunit 0.0173 0.0174 0.0331
Loa Loa (eye worm) G-protein coupled receptor 0.0251 0.0295 0.0448
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0251 0.0295 0.0444
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0173 0.0174 0.026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0251 0.0295 0.0292
Loa Loa (eye worm) hypothetical protein 0.0251 0.0295 0.0448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0251 0.0295 0.0292
Toxoplasma gondii PAN domain-containing protein 0.02 0.0216 0.0358
Brugia malayi neuropeptide F receptor 0.0251 0.0295 0.0444
Loa Loa (eye worm) hypothetical protein 0.02 0.0216 0.0328
Onchocerca volvulus 0.0218 0.0243 0.1262
Loa Loa (eye worm) hypothetical protein 0.0063 0.0003 0.0004
Onchocerca volvulus Neuropeptide F receptor homolog 0.0251 0.0295 0.1532
Schistosoma mansoni biogenic amine receptor 0.0251 0.0295 0.0292

Activities

Activity type Activity value Assay description Source Reference
EC100 (functional) = 3 ug ml-1 Inhibition of platelet aggregation (rabbit platelet-rich plasma),induced by arachidonic acid, (100% inhibitory response) ChEMBL. 10464014
EC100 (functional) = 3 ug ml-1 Inhibition of platelet aggregation (rabbit platelet-rich plasma),induced by arachidonic acid, (100% inhibitory response) ChEMBL. 10464014

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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