Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.1264 | 0.1122 | 0.4234 |
Treponema pallidum | licC protein (licC) | 0.1264 | 0.1122 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1109 | 0.0897 | 0.296 |
Mycobacterium ulcerans | molybdopterin-guanine dinucleotide biosynthesis protein A | 0.1264 | 0.1122 | 0.0778 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0749 | 0.0373 | 0.1741 |
Mycobacterium ulcerans | hypothetical protein | 0.1264 | 0.1122 | 0.0778 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0749 | 0.0373 | 0.1741 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.1897 | 0.2042 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1109 | 0.0897 | 0.296 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.1965 | 0.2142 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1109 | 0.0897 | 0.296 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1109 | 0.0897 | 0.4186 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1109 | 0.0897 | 0.5 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.1965 | 0.2142 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1109 | 0.0897 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1109 | 0.0897 | 0.7694 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1109 | 0.0897 | 0.296 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.1422 | 0.1353 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1109 | 0.0897 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1109 | 0.0897 | 0.296 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1264 | 0.1122 | 0.0778 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1109 | 0.0897 | 0.296 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.1965 | 0.2142 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.7369 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1109 | 0.0897 | 0.5 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.1897 | 0.2042 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.7369 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1109 | 0.0897 | 0.7694 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1109 | 0.0897 | 0.7694 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.1217 | 0.1054 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1109 | 0.0897 | 0.296 |
Mycobacterium ulcerans | hypothetical protein | 0.1264 | 0.1122 | 0.0778 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.1965 | 0.2142 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1264 | 0.1122 | 0.0778 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1109 | 0.0897 | 0.296 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1109 | 0.0897 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.1109 | 0.0897 | 0.4186 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.1422 | 0.1353 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1109 | 0.0897 | 0.7694 |
Chlamydia trachomatis | biotin carboxylase | 0.068 | 0.0273 | 0.5 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.1965 | 0.2142 | 1 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.1965 | 0.2142 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.1965 | 0.2142 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.7369 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CLH (ADMET) | = 0.7 ml/min | Clearance in human hepatocytes | ChEMBL. | 24556380 |
IC50 (functional) | = 7.8 nM | Antagonist activity at human CRTH2 receptor expressed in HEK cells assessed as inhibition of forskolin-induced cAMP formation preincubated for 10 mins followed by forskolin challenge measured after 10 to 60 mins by ELISA assay | ChEMBL. | 24556380 |
Ki (binding) | = 3.4 nM | Antagonist activity at human CRTH2 receptor expressed in CHO-1 cells assessed as inhibition of PGD2-induced Ca2+ flux preincubated for 30 mins followed by PGD2 challenge measured after 60 mins by chemiluminescence assay | ChEMBL. | 24556380 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.