Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acyl-CoA desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | endonuclease G, putative | 0.0108 | 0.0709 | 1 |
Onchocerca volvulus | 0.0386 | 1 | 1 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0179 | 0.309 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0179 | 0.309 | 0.2563 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0179 | 0.309 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.309 | 0.1195 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0386 | 1 | 1 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0108 | 0.0709 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0179 | 0.309 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0108 | 0.0709 | 1 |
Echinococcus granulosus | ectonucleotide | 0.0151 | 0.2152 | 0.6061 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0179 | 0.309 | 0.2563 |
Trypanosoma brucei | endonuclease G, putative | 0.0108 | 0.0709 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0151 | 0.2152 | 0.6061 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0179 | 0.309 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0179 | 0.309 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0179 | 0.309 | 0.2563 |
Onchocerca volvulus | 0.0179 | 0.309 | 0.309 | |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.309 | 0.1195 |
Schistosoma mansoni | hypothetical protein | 0.0386 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0179 | 0.309 | 1 |
Onchocerca volvulus | 0.0179 | 0.309 | 0.309 | |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0179 | 0.309 | 0.2563 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0179 | 0.309 | 0.2563 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0179 | 0.309 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.0151 | 0.2152 | 0.6061 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0179 | 0.309 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0179 | 0.309 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0151 | 0.2152 | 0.6061 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0179 | 0.309 | 1 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0108 | 0.0709 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0108 | 0.0709 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0108 | 0.0709 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0179 | 0.309 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0108 | 0.0709 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0108 | 0.0709 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.309 | 0.1195 |
Leishmania major | endonuclease G, putative | 0.0108 | 0.0709 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 29 nM | Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using Stearoyl-[9,10-3H]-CoA as substrate assessed as [3H2O] generation | ChEMBL. | 24153205 |
IC50 (binding) | = 29 nM | SCD1 Enzymatic Assay | BINDINGDB. | No reference |
INH (binding) | = 16 nM | Inhibition of SCD1 in human A431 cells assessed as conversion of 13C-palmitic acid to 13C-palmitoleic acid after 4 hrs by LC/MS analysis | ChEMBL. | 24153205 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.