Detailed information for compound 1823700

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.474 | Formula: C19H22FN5O2S
  • H donors: 2 H acceptors: 3 LogP: 2.59 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1csc(n1)NC(=O)N1CCC(CC1)N1CCc2c1cc(F)cc2
  • InChi: 1S/C19H22FN5O2S/c1-21-17(26)15-11-28-18(22-15)23-19(27)24-7-5-14(6-8-24)25-9-4-12-2-3-13(20)10-16(12)25/h2-3,10-11,14H,4-9H2,1H3,(H,21,26)(H,22,23,27)
  • InChiKey: PDCACPNCQCDPLU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acyl-CoA desaturase 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi fatty acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Plasmodium knowlesi stearoyl-CoA desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Leishmania mexicana stearic acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Loa Loa (eye worm) acyl-CoA desaturase Get druggable targets OG5_126939 All targets in OG5_126939
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative Get druggable targets OG5_126939 All targets in OG5_126939
Candida albicans one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase Get druggable targets OG5_126939 All targets in OG5_126939
Leishmania infantum fatty-acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Trypanosoma cruzi fatty acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Trypanosoma cruzi fatty acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Leishmania donovani fatty-acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Trypanosoma brucei gambiense fatty acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Leishmania major fatty-acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Trypanosoma brucei fatty acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Plasmodium yoelii delta-9 fatty acid desaturase Get druggable targets OG5_126939 All targets in OG5_126939
Candida albicans one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase Get druggable targets OG5_126939 All targets in OG5_126939
Leishmania donovani stearic acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Onchocerca volvulus Get druggable targets OG5_126939 All targets in OG5_126939
Leishmania braziliensis stearic acid desaturase Get druggable targets OG5_126939 All targets in OG5_126939
Leishmania braziliensis fatty-acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Neospora caninum fatty acyl-CoA desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Trypanosoma congolense fatty acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Brugia malayi acyl-CoA desaturase Get druggable targets OG5_126939 All targets in OG5_126939
Plasmodium falciparum stearoyl-CoA desaturase Get druggable targets OG5_126939 All targets in OG5_126939
Plasmodium berghei stearoyl-CoA desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Leishmania infantum stearic acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Leishmania major stearic acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Leishmania mexicana fatty-acid desaturase, putative Get druggable targets OG5_126939 All targets in OG5_126939
Onchocerca volvulus Get druggable targets OG5_126939 All targets in OG5_126939
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase Acyl-CoA desaturase 1   358 aa 317 aa 27.1 %
Candida albicans one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase Acyl-CoA desaturase 1   358 aa 317 aa 27.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus natriuretic peptide receptor 1 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase HCK 0.0171 1 0.5
Schistosoma mansoni protein kinase 0.0171 1 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0171 1 0.5
Loa Loa (eye worm) protein kinase domain-containing protein 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Plasmodium falciparum protein kinase, putative 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Leishmania major protein kinase, putative 0.0171 1 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Echinococcus multilocularis insulin receptor 0.0171 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0171 1 0.5
Brugia malayi Tyrosine-protein kinase PR2 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Echinococcus multilocularis tyrosine kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0171 1 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0171 1 0.5
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0171 1 0.5
Brugia malayi hypothetical protein 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Loa Loa (eye worm) TK/FAK protein kinase 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0171 1 0.5
Schistosoma mansoni protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0171 1 0.5
Echinococcus granulosus kinase suppressor of Ras 1 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Echinococcus multilocularis protein KINase family member (kin 25) 0.0171 1 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Schistosoma mansoni protein tyrosine kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0171 1 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0171 1 0.5
Entamoeba histolytica hypothetical protein 0.0171 1 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Entamoeba histolytica ankyrin repeat protein 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0171 1 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis protein kinase atn1, putative 0.0171 1 0.5
Schistosoma mansoni serine/threonine RGC 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0171 1 0.5
Echinococcus granulosus tyrosine kinase 0.0171 1 0.5
Echinococcus multilocularis tyrosine kinase 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Srms 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Schistosoma mansoni protein kinase 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0171 1 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0171 1 0.5
Entamoeba histolytica receptor protein kinase, putative 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica hypothetical protein 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase pr2 0.0171 1 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Brugia malayi Raf kinase 0.0171 1 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Blk 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Echinococcus multilocularis protein kinase 0.0171 1 0.5
Entamoeba histolytica ankyrin repeat protein 0.0171 1 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0171 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0171 1 0.5
Echinococcus multilocularis transfer RNA-Thr 0.0171 1 0.5
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0171 1 0.5
Echinococcus multilocularis protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.0171 1 0.5
Echinococcus multilocularis kinase suppressor of Ras 1 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica hypothetical protein 0.0171 1 0.5
Schistosoma mansoni tyrosine protein kinase 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0171 1 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0171 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0171 1 0.5
Brugia malayi SH2 domain containing protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Entamoeba histolytica cysteine surface protein, putative 0.0171 1 0.5
Brugia malayi SH2 domain containing protein 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Trypanosoma brucei protein kinase, putative 0.0171 1 1
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Loa Loa (eye worm) SRC-1 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0171 1 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Brugia malayi hypothetical protein 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Echinococcus multilocularis ephrin type A receptor 4 A 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Trypanosoma cruzi protein kinase, putative 0.0171 1 1
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Entamoeba histolytica hypothetical protein 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0171 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0171 1 0.5
Entamoeba histolytica hypothetical protein 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Echinococcus multilocularis integrin linked protein kinase 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0171 1 0.5
Brugia malayi protein-tyrosine kinase 0.0171 1 0.5
Schistosoma mansoni protein kinase 0.0171 1 0.5
Brugia malayi hypothetical protein 0.0171 1 0.5
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0171 1 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0171 1 0.5
Schistosoma mansoni protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Echinococcus granulosus protein kinase 0.0171 1 0.5
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0171 1 0.5
Echinococcus multilocularis receptor type guanylyl cyclase 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase HCK 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Loa Loa (eye worm) serine/threonine protein kinase 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Giardia lamblia Kinase, NEK 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Schistosoma mansoni ephrin receptor 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0171 1 0.5
Echinococcus multilocularis c src tyrosine kinase 0.0171 1 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0171 1 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0171 1 0.5
Trypanosoma brucei Pseudokinase, putative 0.0171 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase shark 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Toxoplasma gondii STE kinase 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0171 1 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0171 1 0.5
Toxoplasma gondii protein kinase domain-containing protein 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Echinococcus granulosus c src tyrosine kinase 0.0171 1 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0171 1 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0171 1 0.5
Echinococcus multilocularis activin receptor type 0.0171 1 0.5
Entamoeba histolytica hypothetical protein 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Echinococcus multilocularis natriuretic peptide receptor 1 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0171 1 0.5
Echinococcus multilocularis protein tyrosine kinase 0.0171 1 0.5
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0171 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0171 1 0.5
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0171 1 0.5
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Loa Loa (eye worm) TK/ALK protein kinase 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0171 1 1
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0171 1 0.5
Echinococcus granulosus insulin receptor 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase pr2 0.0171 1 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0171 1 0.5
Echinococcus multilocularis FL cytokine receptor 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Leishmania major hypothetical protein, conserved 0.0171 1 1
Loa Loa (eye worm) TK protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Schistosoma mansoni protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TK/EPH protein kinase 0.0171 1 0.5
Echinococcus granulosus protein tyrosine kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0171 1 0.5
Brugia malayi Furin-like cysteine rich region family protein 0.0171 1 0.5
Loa Loa (eye worm) TK/ACK protein kinase 0.0171 1 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Schistosoma mansoni protein kinase 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0171 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Blk 0.0171 1 0.5
Echinococcus granulosus tyrosine kinase 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Echinococcus granulosus receptor type guanylyl cyclase 0.0171 1 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Loa Loa (eye worm) TK/RYK protein kinase 0.0171 1 0.5
Brugia malayi C-terminal src kinase protein 1 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0171 1 0.5
Brugia malayi ephrin receptor 1 precursor 0.0171 1 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TK family protein kinase 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Loa Loa (eye worm) TK/DDR protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TK/Met protein kinase 0.0171 1 0.5
Schistosoma mansoni ephrin receptor 0.0171 1 0.5
Schistosoma mansoni protein kinase 0.0171 1 0.5
Brugia malayi Guanylyl cyclase protein 23 0.0171 1 0.5
Brugia malayi Tyrosine-protein kinase abl-1 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Brugia malayi Receptor family ligand binding region containing protein 0.0171 1 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Plasmodium falciparum protein kinase, putative 0.0171 1 0.5
Loa Loa (eye worm) TK/CSK protein kinase 0.0171 1 0.5
Trichomonas vaginalis STE family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Plasmodium vivax protein kinase, putative 0.0171 1 0.5
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0171 1 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.0171 1 0.5
Echinococcus granulosus tyrosine kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0171 1 0.5
Trichomonas vaginalis AGC family protein kinase 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Trypanosoma cruzi protein kinase, putative 0.0171 1 1
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Toxoplasma gondii protein kinase 0.0171 1 0.5
Echinococcus granulosus fibroblast growth factor receptor 4 0.0171 1 0.5
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0171 1 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0171 1 0.5
Echinococcus granulosus integrin linked protein kinase 0.0171 1 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0171 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0171 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Brugia malayi integrin-linked kinase 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Schistosoma mansoni hypothetical protein 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0171 1 0.5
Entamoeba histolytica hypothetical protein 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0171 1 0.5
Echinococcus multilocularis activated cdc42 kinase 1 0.0171 1 0.5
Brugia malayi bone morphogenetic protein type 1 receptor 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0171 1 0.5
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0171 1 0.5
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0171 1 0.5
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0171 1 0.5
Echinococcus granulosus ephrin type A receptor 4 A 0.0171 1 0.5
Entamoeba histolytica hypothetical protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0171 1 1
Entamoeba histolytica hypothetical protein 0.0171 1 0.5
Brugia malayi SRC-1 0.0171 1 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0171 1 1
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Echinococcus granulosus activin receptor type 0.0171 1 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0171 1 0.5
Giardia lamblia Kinase, NEK 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Plasmodium falciparum protein kinase, putative 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase shark 0.0171 1 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0171 1 0.5
Entamoeba histolytica hypothetical protein 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0171 1 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0171 1 0.5
Echinococcus granulosus raf serine:threonine protein kinase 0.0171 1 0.5
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0171 1 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0171 1 0.5
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0171 1 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0171 1 0.5
Brugia malayi Protein kinase domain containing protein 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Leishmania major protein kinase, putative 0.0171 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0171 1 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0171 1 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0171 1 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Schistosoma mansoni protein kinase 0.0171 1 0.5
Entamoeba histolytica receptor protein kinase, putative 0.0171 1 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0171 1 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Giardia lamblia Kinase 0.0171 1 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0171 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0171 1 0.5
Schistosoma mansoni protein kinase 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0171 1 0.5
Echinococcus multilocularis raf serine:threonine protein kinase 0.0171 1 0.5
Entamoeba histolytica protein kinase, putative 0.0171 1 0.5
Onchocerca volvulus 0.0171 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0171 1 0.5
Giardia lamblia Protein 21.1 0.0171 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0171 1 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0171 1 0.5
Schistosoma mansoni protein kinase 0.0171 1 0.5
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0171 1 1
Loa Loa (eye worm) hypothetical protein 0.0171 1 0.5
Loa Loa (eye worm) TK protein kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Schistosoma mansoni tyrosine kinase 0.0171 1 0.5
Trichomonas vaginalis TKL family protein kinase 0.0171 1 0.5
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0171 1 0.5
Entamoeba histolytica hypothetical protein 0.0171 1 0.5
Onchocerca volvulus Tyrosine kinase homolog 0.0171 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 1000 nM SCD1 Enzymatic Assay BINDINGDB. No reference
Inhibition (binding) = 20 % Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using Stearoyl-[9,10-3H]-CoA as substrate assessed as [3H2O] generation at 1 uM ChEMBL. 24153205

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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