Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | choline O acetyltransferase | 0.0042 | 0.0013 | 0.0013 |
Schistosoma mansoni | choline o-acyltransferase | 0.0042 | 0.0013 | 0.0035 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0124 | 0.1207 | 0.3142 |
Schistosoma mansoni | hypothetical protein | 0.0306 | 0.384 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0306 | 0.384 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0042 | 0.0013 | 0.0037 |
Echinococcus granulosus | geminin | 0.0306 | 0.384 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.3638 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0042 | 0.0013 | 0.0037 |
Brugia malayi | Choline O-acetyltransferase | 0.0042 | 0.0013 | 0.0037 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0072 | 0.0452 | 0.1244 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0124 | 0.1207 | 0.1207 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0124 | 0.1207 | 0.3317 |
Onchocerca volvulus | 0.0042 | 0.0013 | 0.5 | |
Onchocerca volvulus | 0.0042 | 0.0013 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0117 | 0.1102 | 0.287 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0124 | 0.1207 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0042 | 0.0013 | 0.0037 |
Brugia malayi | Cytochrome P450 family protein | 0.0072 | 0.0452 | 0.1244 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0117 | 0.1102 | 0.9122 |
Onchocerca volvulus | 0.0042 | 0.0013 | 0.5 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0117 | 0.1102 | 0.1102 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0013 | 0.0037 |
Echinococcus granulosus | choline O acetyltransferase | 0.0042 | 0.0013 | 0.0035 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0117 | 0.1102 | 0.9122 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0124 | 0.1207 | 0.3317 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0124 | 0.1207 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0124 | 0.1207 | 1 |
Onchocerca volvulus | 0.0042 | 0.0013 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0306 | 0.384 | 0.384 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0292 | 0.3638 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0117 | 0.1102 | 0.9122 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0042 | 0.0013 | 0.0037 |
Schistosoma mansoni | choline o-acyltransferase | 0.0042 | 0.0013 | 0.0035 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 15 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis BCG | ChEMBL. | 24246731 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.