Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0055 | 0.2269 | 0.2792 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0055 | 0.2269 | 0.0931 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.6342 | 0.7777 |
Schistosoma mansoni | patched 1 | 0.0045 | 0.1476 | 0.0962 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0128 | 0.8127 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0045 | 0.1476 | 0.181 |
Echinococcus granulosus | expressed conserved protein | 0.0099 | 0.5825 | 0.5102 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0128 | 0.8127 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0046 | 0.1497 | 0.1842 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.008 | 0.4285 | 0.5255 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.008 | 0.4285 | 0.5273 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0128 | 0.8127 | 0.7802 |
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.008 | 0.4285 | 0.5273 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1344 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1476 | 0.181 |
Schistosoma mansoni | protein kinase | 0.008 | 0.4285 | 0.4779 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0055 | 0.2269 | 0.2792 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2299 | 0.2819 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.8154 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0128 | 0.8127 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.8127 | 0.9966 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0107 | 0.6474 | 0.7754 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2269 | 0.1193 |
Plasmodium vivax | RNA helicase-1, putative | 0.0128 | 0.8127 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0128 | 0.8127 | 0.7802 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0128 | 0.8127 | 0.7802 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0055 | 0.2269 | 0.204 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2134 | 0.2617 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0106 | 0.6342 | 0.7777 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.1497 | 0.1836 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2269 | 0.1193 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.2134 | 0.2617 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.2617 | 0.3209 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0128 | 0.8127 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0055 | 0.2269 | 0.0931 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0128 | 0.8127 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0128 | 0.8127 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0768 | 0.0942 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0055 | 0.2269 | 0.0931 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0128 | 0.8127 | 0.9966 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0128 | 0.8127 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0128 | 0.8127 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0046 | 0.1497 | 0.1836 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1344 | 0.0782 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1344 | 0.0782 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.2134 | 0.2617 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0128 | 0.8127 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.008 | 0.4285 | 0.5273 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.2617 | 0.3209 |
Brugia malayi | Cytochrome P450 family protein | 0.0046 | 0.1497 | 0.1836 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2269 | 0.1193 |
Giardia lamblia | Kinase, STE STE20 | 0.008 | 0.4285 | 0.3441 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0151 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.008 | 0.4285 | 0.4224 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0046 | 0.1497 | 0.1842 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0055 | 0.2269 | 0.2792 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0055 | 0.2269 | 0.2783 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.8154 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0128 | 0.8127 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0046 | 0.1497 | 0.1836 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.008 | 0.4285 | 0.3296 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0128 | 0.8127 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0055 | 0.2269 | 0.2792 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0128 | 0.8127 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.008 | 0.4285 | 0.4224 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0128 | 0.8127 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.2269 | 0.2792 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.008 | 0.4285 | 0.3296 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0128 | 0.8127 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0128 | 0.8127 | 0.7802 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0055 | 0.2269 | 0.2792 |
Brugia malayi | MAP kinase sur-1 | 0.0055 | 0.2269 | 0.2783 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.2269 | 0.2792 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2269 | 0.1193 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0768 | 0.0942 |
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.008 | 0.4285 | 0.5255 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0128 | 0.8127 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0046 | 0.1497 | 0.1842 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.1497 | 0.1836 |
Brugia malayi | CHE-14 protein | 0.0045 | 0.1476 | 0.181 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0128 | 0.8127 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1344 | 0.0782 |
Echinococcus multilocularis | expressed conserved protein | 0.0099 | 0.5825 | 0.5102 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0055 | 0.2269 | 0.2792 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0055 | 0.2269 | 0.0931 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0046 | 0.1497 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0106 | 0.6342 | 0.5709 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.8154 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0128 | 0.8127 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.2134 | 0.2617 |
Trichomonas vaginalis | STE family protein kinase | 0.008 | 0.4285 | 0.4224 |
Trypanosoma brucei | protein kinase, putative | 0.0055 | 0.2269 | 0.2792 |
Echinococcus multilocularis | protein dispatched 1 | 0.0052 | 0.1993 | 0.0606 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0106 | 0.6342 | 0.5709 |
Leishmania major | cytochrome p450-like protein | 0.0046 | 0.1497 | 0.1842 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5 nM | In vitro inhibition of potassium-contracted rabbit aorta strips | ChEMBL. | 1387168 |
Max/average (functional) | = 0 | In vivo evaluation for the antihypertensive effect in the spontaneously hypertensive rat is % decrease in blood pressure during post drug administration at 45 umol/kg peroral; 47/40 | ChEMBL. | 1387168 |
Max/average (functional) | = 0 | In vivo evaluation for the antihypertensive effect in the spontaneously hypertensive rat is % decrease in blood pressure during post drug administration at 15 uM/kg peroral; 46/22 | ChEMBL. | 1387168 |
Max/average (functional) | = 0 | In vivo evaluation for the antihypertensive effect in the spontaneously hypertensive rat is % decrease in blood pressure during post drug administration at 5 umol/kg peroral; 37/17 | ChEMBL. | 1387168 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.