TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.357 | Formula: C19H17N3O2
H donors: 0 H acceptors: 3 LogP: 3.41 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)C(=O)CCN2c1nc(C)nc2c1cccc2
InChi: 1S/C19H17N3O2/c1-12-20-16-6-4-3-5-14(16)19(21-12)22-10-9-18(23)15-11-13(24-2)7-8-17(15)22/h3-8,11H,9-10H2,1-2H3
InChiKey: YDGUDCQXTXPHLC-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tubulin, beta 2B class IIb	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium falciparum	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania infantum	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Cryptosporidium hominis	beta-catenin-like repeat protein	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin gamma chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium vivax	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Brugia malayi	Tubulin beta-1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta-1 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin beta 1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania infantum	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Neospora caninum	hypothetical protein	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium yoelii	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Babesia bovis	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta-7 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana		Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	tubulin beta 4A class IVa	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta-4 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta-1 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Theileria parva	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei gambiense	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma congolense	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma cruzi	beta tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	ko:K07375 tubulin beta, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Giardia lamblia	Beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Cryptosporidium parvum	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Toxoplasma gondii	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin beta-4 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Brugia malayi	beta-tubulin, identical	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Toxoplasma gondii	beta-1 tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Entamoeba histolytica	tubulin family protein	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium berghei	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania infantum	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Neospora caninum	hypothetical protein	Get druggable targets OG5_126611	All targets in OG5_126611
Neospora caninum	hypothetical protein	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Entamoeba histolytica	tubulin family protein	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin beta-1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin alpha chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	BEN-1 protein	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	ko:K07375 tubulin beta, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	tubulin beta 1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Toxoplasma gondii	beta-tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Giardia lamblia	Beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Giardia lamblia	Beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin, beta 4A class IVa	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei gambiense	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin beta-2A chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania infantum	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	BEN-1 protein	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	tubulin gamma chain	tubulin, beta 2B class IIb	445 aa	438 aa	32.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Wolbachia endosymbiont of Brugia malayi	Xaa-Pro aminopeptidase	0.0018	0	0.5
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Echinococcus multilocularis	Tubulin beta 2C chain	0.003	0.0916	0.0916
Toxoplasma gondii	methionine aminopeptidase 2, putative	0.0146	1	1
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Loa Loa (eye worm)	BEN-1 protein	0.003	0.0916	0.0916
Trichomonas vaginalis	tubulin epsilon chain, putative	0.003	0.0916	0.0916
Trichomonas vaginalis	tubulin alpha chain, putative	0.003	0.0916	0.0916
Echinococcus granulosus	beta tubulin	0.003	0.0916	0.0916
Entamoeba histolytica	methionine aminopeptidase, putative	0.0146	1	1
Onchocerca volvulus	Methionine aminopeptidase 2 homolog	0.0146	1	1
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Loa Loa (eye worm)	beta-tubulin	0.003	0.0916	0.0916
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0146	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.003	0.0916	0.0916
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0146	1	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.003	0.0916	0.0916
Plasmodium falciparum	tubulin beta chain	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0146	1	1
Trypanosoma brucei	beta tubulin	0.003	0.0916	0.0916
Loa Loa (eye worm)	tubulin beta-1 chain	0.003	0.0916	0.0916
Schistosoma mansoni	tubulin subunit beta	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Plasmodium vivax	methionine aminopeptidase 2, putative	0.0146	1	1
Schistosoma mansoni	tubulin subunit beta	0.003	0.0916	0.0916
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.003	0.0916	0.0916
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0018	0	0.5
Schistosoma mansoni	tubulin subunit beta	0.003	0.0916	0.0916
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0146	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.003	0.0916	0.0916
Trichomonas vaginalis	tubulin, putative	0.003	0.0916	0.0916
Echinococcus granulosus	tubulin subunit beta	0.003	0.0916	0.0916
Chlamydia trachomatis	aminopeptidase P	0.0018	0	0.5
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0146	1	1
Treponema pallidum	aminopeptidase P	0.0018	0	0.5
Echinococcus granulosus	tubulin beta 1 chain	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Trichomonas vaginalis	tubulin beta chain, putative	0.003	0.0916	0.0916
Mycobacterium ulcerans	methionine aminopeptidase	0.0018	0	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.003	0.0916	0.0916
Chlamydia trachomatis	methionine aminopeptidase	0.0018	0	0.5
Mycobacterium ulcerans	cytoplasmic peptidase PepQ	0.0018	0	0.5
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0018	0	0.5
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0146	1	1
Echinococcus granulosus	methionyl aminopeptidase 2	0.0146	1	1
Mycobacterium ulcerans	dipeptidase	0.0018	0	0.5
Echinococcus multilocularis	tubulin beta 1 chain	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Schistosoma mansoni	tubulin subunit beta	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Mycobacterium leprae	Probable cytoplasmic peptidase PepQ	0.0018	0	0.5
Echinococcus multilocularis	Tubulin beta 2C chain	0.003	0.0916	0.0916
Echinococcus granulosus	beta tubulin	0.003	0.0916	0.0916
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0146	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.003	0.0916	0.0916
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0018	0	0.5
Toxoplasma gondii	beta tubulin	0.003	0.0916	0.0916
Giardia lamblia	Methionine aminopeptidase	0.0146	1	1
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0146	1	1
Plasmodium vivax	tubulin beta chain, putative	0.003	0.0916	0.0916
Brugia malayi	beta-tubulin, identical	0.003	0.0916	0.0916
Mycobacterium tuberculosis	Dipeptidase PepE	0.0018	0	0.5
Toxoplasma gondii	beta-tubulin, putative	0.003	0.0916	0.0916
Echinococcus granulosus	Tubulin beta 2C chain	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Echinococcus granulosus	Tubulin beta 2C chain	0.003	0.0916	0.0916
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0146	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0146	1	1
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0018	0	0.5
Entamoeba histolytica	tubulin family protein	0.003	0.0916	0.0916
Echinococcus multilocularis	beta tubulin	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Loa Loa (eye worm)	tubulin beta chain	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Echinococcus multilocularis	Tubulin beta 2C chain	0.003	0.0916	0.0916
Giardia lamblia	Beta tubulin	0.003	0.0916	0.0916
Trypanosoma brucei	beta tubulin	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Treponema pallidum	methionine aminopeptidase (map)	0.0018	0	0.5
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0146	1	1
Entamoeba histolytica	tubulin family protein	0.003	0.0916	0.0916
Trypanosoma cruzi	beta tubulin, putative	0.003	0.0916	0.0916
Echinococcus multilocularis	tubulin subunit beta	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Loa Loa (eye worm)	tubulin beta-4 chain	0.003	0.0916	0.0916
Brugia malayi	Tubulin beta-1 chain	0.003	0.0916	0.0916
Echinococcus granulosus	tubulin beta 4A class IVa	0.003	0.0916	0.0916
Trypanosoma brucei	beta tubulin	0.003	0.0916	0.0916
Schistosoma mansoni	tubulin subunit beta	0.003	0.0916	0.0916
Leishmania major	methionine aminopeptidase 2, putative	0.0146	1	1
Schistosoma mansoni	tubulin subunit beta	0.003	0.0916	0.0916
Mycobacterium ulcerans	dipeptidase PepE	0.0018	0	0.5
Plasmodium falciparum	methionine aminopeptidase 2	0.0146	1	1
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0018	0	0.5
Loa Loa (eye worm)	BEN-1 protein	0.003	0.0916	0.0916
Giardia lamblia	Beta tubulin	0.003	0.0916	0.0916
Echinococcus granulosus	Tubulin beta 2C chain	0.003	0.0916	0.0916
Echinococcus multilocularis	Tubulin beta 2C chain	0.003	0.0916	0.0916
Giardia lamblia	Beta tubulin	0.003	0.0916	0.0916
Leishmania major	beta tubulin	0.003	0.0916	0.0916
Mycobacterium ulcerans	aminopeptidase	0.0018	0	0.5
Toxoplasma gondii	beta-1 tubulin, putative	0.003	0.0916	0.0916
Echinococcus multilocularis	beta tubulin	0.003	0.0916	0.0916
Trypanosoma brucei	beta tubulin	0.003	0.0916	0.0916
Mycobacterium tuberculosis	Probable cytoplasmic peptidase PepQ	0.0018	0	0.5
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0018	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.94 uM	Inhibition of tubulin (unknown origin) polymerization incubated for 15 mins prior to GTP addition measured after 20 mins by turbidimetry	ChEMBL.	24502232
Inhibition (binding)	= 56 %	Displacement of [3H]colchine from tubulin (unknown origin) at 1 uM after 10 mins	ChEMBL.	24502232
Inhibition (binding)	= 87 %	Displacement of [3H]colchine from tubulin (unknown origin) at 5 uM after 10 mins	ChEMBL.	24502232
T1/2 (ADMET)	= 20.89 min	Half life in human liver microsomes at 1 uM by LC-MS analysis	ChEMBL.	24502232

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3126922

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1827625