Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetyl-CoA carboxylase alpha | Starlite/ChEMBL | References |
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 359 nM | Inhibition of human ACC2 expressed in CHOK1 cells assessed as acetylCoA to malonylCoA conversion after 1 hr by LC-MS/MS analysis | ChEMBL. | 24294923 |
IC50 (binding) | = 841 nM | Inhibition of human ACC2 assessed as acetylCoA to malonylCoA conversion after 10 mins by LC-MS/MS analysis | ChEMBL. | 24294923 |
IC50 (binding) | = 4280 nM | Inhibition of human ACC1 assessed as acetylCoA to malonylCoA conversion after 10 mins by LC-MS/MS analysis | ChEMBL. | 24294923 |
Inhibition (binding) | Inhibition of ACC1 in rat FaO cells | ChEMBL. | 24294923 | |
Inhibition (binding) | Inhibition of ACC1 in rat H9c2 cells | ChEMBL. | 24294923 | |
Inhibition (binding) | Inhibition of ACC1 in rat L6 cells | ChEMBL. | 24294923 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.