Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 17, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Cytochrome P450 17A1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0104 | 0.027 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0866 | 0.7848 | 0.7848 |
Trypanosoma brucei | lipase domain protein, putative | 0.1082 | 1 | 1 |
Loa Loa (eye worm) | amidase | 0.0104 | 0.027 | 0.027 |
Brugia malayi | putative amidase | 0.0104 | 0.027 | 0.027 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0104 | 0.027 | 0.027 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.7848 | 0.7848 |
Onchocerca volvulus | 0.1082 | 1 | 1 | |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0866 | 0.7848 | 1 |
Brugia malayi | Amidase family protein | 0.0104 | 0.027 | 0.027 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0104 | 0.027 | 0.027 |
Brugia malayi | amidase | 0.0866 | 0.7848 | 0.7848 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.026 | 0.1816 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.1082 | 1 | 1 |
Loa Loa (eye worm) | lipase | 0.1082 | 1 | 1 |
Loa Loa (eye worm) | amidase | 0.0104 | 0.027 | 0.027 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0104 | 0.027 | 0.0343 |
Brugia malayi | Amidase family protein | 0.0104 | 0.027 | 0.027 |
Schistosoma mansoni | amidase | 0.0866 | 0.7848 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1082 | 1 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.1082 | 1 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0104 | 0.027 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0866 | 0.7848 | 0.7848 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0104 | 0.027 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0104 | 0.027 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0104 | 0.027 | 0.027 |
Leishmania major | hypothetical protein, conserved | 0.1082 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1082 | 1 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0104 | 0.027 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0866 | 0.7848 | 0.7848 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.1082 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.026 | 0.1816 | 1 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0104 | 0.027 | 0.027 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0104 | 0.027 | 0.5 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0104 | 0.027 | 0.0343 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1082 | 1 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0866 | 0.7848 | 0.7848 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0104 | 0.027 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 400 nM | Inhibition of human testicular microsomal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
IC50 (binding) | = 400 nM | Inhibition of human testicular microsomal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
IC50 (binding) | = 1500 nM | Inhibition of rat testicual micrososmal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
IC50 (binding) | = 1500 nM | Inhibition of rat testicual micrososmal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
Inhibition (binding) | % | Percent inhibition of rat testicular microsomal Cytochrome P450 17A1; No Inhibition | ChEMBL. | 9379450 |
Inhibition (binding) | 0 % | Percent inhibition of rat testicular microsomal Cytochrome P450 17A1; No Inhibition | ChEMBL. | 9379450 |
Inhibition (binding) | = 21 % | Percent inhibition of human testicular microsomal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
Inhibition (binding) | = 21 % | Percent inhibition of human testicular microsomal Cytochrome P450 17A1 | ChEMBL. | 9379450 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.