Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0034 | 0.0042 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0771 | 0.0771 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.0034 | 0.0034 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0034 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0034 | 0.0042 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0034 | 0.0042 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0034 | 0.0042 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0034 | 0.0042 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0034 | 0.0042 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0034 | 0.0042 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.1731 | 0.1731 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.0034 | 0.0042 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0034 | 0.0042 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0034 | 0.0042 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0034 | 0.0042 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.0034 | 0.0034 |
Brugia malayi | Protein kinase domain containing protein | 0.0658 | 0.8156 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0147 | 0.1731 | 0.1731 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0034 | 0.0042 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.0034 | 0.0042 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0034 | 0.0042 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.0771 | 0.0946 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.0771 | 0.0946 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0034 | 0.0034 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.0034 | 0.0034 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.0034 | 0.0034 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.0034 | 0.0034 |
Schistosoma mansoni | thyroid hormone receptor | 0.0159 | 0.188 | 0.188 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0771 | 0.0771 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.0034 | 0.0034 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.0034 | 0.0042 |
Giardia lamblia | Kinase, TTK | 0.0658 | 0.8156 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0034 | 0.0042 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.0771 | 0.0946 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0658 | 0.8156 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.0034 | 0.0042 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.0034 | 0.0034 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.0034 | 0.0042 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.1554 | 0.1906 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0034 | 0.0034 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0805 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0034 | 0.0042 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0771 | 0.0771 |
Loa Loa (eye worm) | TTK protein kinase | 0.0658 | 0.8156 | 1 |
Brugia malayi | TAR-binding protein | 0.007 | 0.0771 | 0.0946 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0034 | 0.0034 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.0034 | 0.0034 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.0034 | 0.0042 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.0034 | 0.0034 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0034 | 0.0042 |
Schistosoma mansoni | thyroid hormone receptor | 0.0159 | 0.188 | 0.188 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0034 | 0.0042 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.0034 | 0.0042 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0034 | 0.0042 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0034 | 0.0042 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.0771 | 0.0771 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.0034 | 0.0034 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0034 | 0.0042 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0034 | 0.0034 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.0034 | 0.0042 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.1554 | 0.1906 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.0771 | 0.0771 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0771 | 0.0771 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0147 | 0.1731 | 0.1731 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0034 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0034 | 0.0042 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.0034 | 0.0034 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0658 | 0.8156 | 0.8156 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.1554 | 0.1906 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0658 | 0.8156 | 0.8156 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.0034 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0034 | 0.0042 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.0034 | 0.0034 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0034 | 0.0034 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0658 | 0.8156 | 0.8156 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.0034 | 0.0034 |
Brugia malayi | RNA binding protein | 0.007 | 0.0771 | 0.0946 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.0771 | 0.0946 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0658 | 0.8156 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0034 | 0.0042 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0034 | 0.0042 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0034 | 0.0034 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0805 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0034 | 0.0042 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0034 | 0.0034 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0034 | 0.0034 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0159 | 0.188 | 0.188 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0034 | 0.0034 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0658 | 0.8156 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0771 | 0.0771 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0034 | 0.0042 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.