Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | alkaline phosphatase 3, intestine, not Mn requiring | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.0108 | 0.0956 | 0.0893 |
Schistosoma mansoni | alkaline phosphatase | 0.0196 | 0.2235 | 0.218 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0077 | 0.051 | 0.1843 |
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.0108 | 0.0956 | 0.0893 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0067 | 0.0379 | 0.0535 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0196 | 0.2235 | 0.1929 |
Entamoeba histolytica | ubiquitin-activating enzyme E1 1, putative | 0.013 | 0.1274 | 0.1274 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1 X, putative | 0.0069 | 0.04 | 0.0565 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0233 | 0.2768 | 1 |
Brugia malayi | ube1-prov protein | 0.0162 | 0.1738 | 0.1412 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0162 | 0.1738 | 0.1738 |
Echinococcus multilocularis | alkaline phosphatase | 0.0196 | 0.2235 | 0.1929 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0379 | 0.0379 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0077 | 0.051 | 0.0444 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0196 | 0.2235 | 0.1929 |
Schistosoma mansoni | ubiquitin-activating enzyme E1 | 0.0134 | 0.1338 | 0.1277 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0196 | 0.2235 | 0.1929 |
Entamoeba histolytica | ThiF family protein | 0.0067 | 0.0379 | 0.0379 |
Echinococcus granulosus | ubiquitin modifier activating enzyme 1 | 0.0162 | 0.1738 | 0.1412 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0095 | 0.0781 | 0.1686 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.013 | 0.1274 | 0.18 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0073 | 0.0463 | 0.0354 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0065 | 0.034 | 0.0481 |
Toxoplasma gondii | ThiF family protein | 0.0067 | 0.0379 | 0.0379 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0533 | 0.708 | 1 |
Giardia lamblia | Ubiquitin-conjugating enzyme E1 | 0.0095 | 0.0781 | 0.5 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.013 | 0.1274 | 0.18 |
Trypanosoma cruzi | NEDD8-activating enzyme E1 regulatory subunit, putative | 0.0067 | 0.0379 | 0.0277 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.0876 | 0.0812 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 1 | 0.0162 | 0.1738 | 0.1412 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.0233 | 0.2768 | 1 |
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.0095 | 0.0781 | 0.1686 |
Echinococcus granulosus | ubiquitin modifier activating enzyme 6 | 0.0162 | 0.1738 | 0.1412 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0077 | 0.051 | 0.1843 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0077 | 0.051 | 0.0137 |
Plasmodium falciparum | ubiquitin-activating enzyme E1 | 0.0162 | 0.1738 | 0.6278 |
Loa Loa (eye worm) | ube1-prov protein | 0.0162 | 0.1738 | 0.1738 |
Toxoplasma gondii | hypothetical protein | 0.0077 | 0.051 | 0.051 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0095 | 0.0781 | 0.1916 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0233 | 0.2768 | 1 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0196 | 0.2235 | 0.1929 |
Brugia malayi | ThiF family protein | 0.0077 | 0.051 | 0.0137 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 6 | 0.0162 | 0.1738 | 0.1412 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0095 | 0.0781 | 0.1916 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0196 | 0.2235 | 0.1929 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0077 | 0.051 | 0.0137 |
Trypanosoma brucei | NEDD8 activating enzyme subunit, putative | 0.0233 | 0.2768 | 1 |
Echinococcus granulosus | alkaline phosphatase | 0.0196 | 0.2235 | 0.1929 |
Schistosoma mansoni | alkaline phosphatase | 0.0196 | 0.2235 | 0.218 |
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.0073 | 0.0463 | 0.0354 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0196 | 0.2235 | 0.1929 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.051 | 0.051 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1c, putative | 0.013 | 0.1274 | 0.18 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0067 | 0.0379 | 0.0535 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0242 | 0.2895 | 0.5 |
Leishmania major | ubiquitin activating enzyme, putative | 0.0233 | 0.2768 | 1 |
Schistosoma mansoni | app binding protein | 0.0067 | 0.0379 | 0.0311 |
Trichomonas vaginalis | molybdopterin biosynthesis moeb protein, putative | 0.0233 | 0.2768 | 0.3909 |
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.0233 | 0.2768 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.53 uM | Inhibition of mouse duodenal-specific FLAG-tagged IAP expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay | ChEMBL. | 24412070 |
IC50 (binding) | = 37 uM | Inhibition of FLAG-tagged TNAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay | ChEMBL. | 24412070 |
IC50 (binding) | > 100 uM | Inhibition of FLAG-tagged PLAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay | ChEMBL. | 24412070 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.