TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 382.252 | Formula: C16H20BrN3O3
H donors: 0 H acceptors: 2 LogP: 3.05 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(OC)cc(cc1c1noc(n1)C1CCCN(C1)C)Br
InChi: 1S/C16H20BrN3O3/c1-20-6-4-5-10(9-20)16-18-15(19-23-16)12-7-11(17)8-13(21-2)14(12)22-3/h7-8,10H,4-6,9H2,1-3H3
InChiKey: BMLYDPYFLMNUPC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0207	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0114	0.5339	0.5339
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0023	0.0834	0.0834
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0114	0.5339	0.5339
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0039	0.161	0.161
Echinococcus multilocularis	serotonin receptor	0.0114	0.5339	0.5339
Mycobacterium tuberculosis	Probable oxidoreductase	0.0023	0.0834	1
Schistosoma mansoni	serine protease inhibitors serpins	0.0014	0.0367	0.0367
Entamoeba histolytica	serine protease inhibitor, putative	0.0014	0.0367	0.0367
Schistosoma mansoni	neuropeptide F-like receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Echinococcus granulosus	serine protease inhibitor	0.0014	0.0367	0.0367
Entamoeba histolytica	aldose reductase, putative	0.0023	0.0834	0.0834
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0207	1	1
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Trichomonas vaginalis	aldo/keto reductase, putative	0.0023	0.0834	0.0834
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0114	0.5339	0.5339
Brugia malayi	Serpin protein 6	0.0014	0.0367	0.0367
Brugia malayi	Serotonin receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	serotonin receptor	0.0114	0.5339	0.5339
Brugia malayi	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0114	0.5339	0.5339
Brugia malayi	sulfakinin receptor protein	0.0114	0.5339	0.5339
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.161	0.161
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Echinococcus granulosus	neuropeptide Y receptor	0.0114	0.5339	0.5339
Mycobacterium ulcerans	oxidoreductase	0.0023	0.0834	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0114	0.5339	0.5339
Entamoeba histolytica	aldose reductase, putative	0.0023	0.0834	0.0834
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0367	0.0367
Onchocerca volvulus		0.0114	0.5339	0.6674
Onchocerca volvulus		0.0114	0.5339	0.6674
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0114	0.5339	0.5339
Loa Loa (eye worm)	neuropeptide F receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	sex peptide receptor	0.0114	0.5339	0.5339
Onchocerca volvulus		0.0114	0.5339	0.6674
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0023	0.0834	0.0834
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0207	1	1
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0008	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0114	0.5339	0.5339
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Brugia malayi	hypothetical protein	0.0114	0.5339	0.5339
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0167	0.8	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0114	0.5339	0.5339
Onchocerca volvulus		0.0014	0.0367	0.0459
Echinococcus granulosus	dro:myosuppressin receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	histamine h1 receptor	0.0114	0.5339	0.5339
Brugia malayi	GnHR receptor homolog	0.0114	0.5339	0.5339
Brugia malayi	follicle stimulating hormone receptor	0.0114	0.5339	0.5339
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0023	0.0834	0.0834
Brugia malayi	AKH receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	aldo keto reductase	0.0023	0.0834	0.0834
Loa Loa (eye worm)	oxidoreductase	0.0023	0.0834	0.0834
Brugia malayi	hypothetical protein	0.0014	0.0367	0.0367
Brugia malayi	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	Dopamine receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	Estrogen regulated protein EP45	0.0014	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Schistosoma mansoni	adenoreceptor	0.0114	0.5339	0.5339
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0039	0.161	0.161
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0114	0.5339	0.5339
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0367	0.0367
Trypanosoma cruzi	aldo-keto reductase	0.0023	0.0834	0.0834
Brugia malayi	hypothetical protein	0.0114	0.5339	0.5339
Schistosoma mansoni	amine GPCR	0.0114	0.5339	0.5339
Schistosoma mansoni	pol-related	0.0023	0.0834	0.0834
Toxoplasma gondii	protease inhibitor PI1	0.0014	0.0367	0.0367
Echinococcus granulosus	neuropeptide receptor A26	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0008	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0367	0.0367
Brugia malayi	serpin	0.0014	0.0367	0.0367
Leishmania major	prostaglandin f synthase, putative	0.0023	0.0834	0.0834
Echinococcus granulosus	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Echinococcus granulosus	neuropeptide Y receptor	0.0114	0.5339	0.5339
Trichomonas vaginalis	aldo/keto reductase, putative	0.0023	0.0834	0.0834
Brugia malayi	RE15519p	0.0114	0.5339	0.5339
Onchocerca volvulus		0.0014	0.0367	0.0459
Onchocerca volvulus		0.0014	0.0367	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	hypothetical protein	0.0014	0.0367	0.0367
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0207	1	1
Toxoplasma gondii	serpin (serine proteinase inhibitor) superfamily protein	0.0014	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	somatostatin receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	neuropeptide f receptor 76f	0.0114	0.5339	0.5339
Onchocerca volvulus		0.0114	0.5339	0.6674
Echinococcus granulosus	g protein coupled receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0114	0.5339	0.5339
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	sex peptide receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0114	0.5339	0.5339
Echinococcus multilocularis	aldehyde reductase	0.0017	0.0494	0.0494
Onchocerca volvulus		0.0114	0.5339	0.6674
Loa Loa (eye worm)	neuropeptide F receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0114	0.5339	0.5339
Onchocerca volvulus		0.0014	0.0367	0.0459
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0023	0.0834	0.0834
Schistosoma mansoni	opsin-like receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0114	0.5339	0.5339
Brugia malayi	G protein-coupled receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0114	0.5339	0.5339
Echinococcus granulosus	7TM GPCR rhodopsin	0.0114	0.5339	0.5339
Echinococcus granulosus	muscleblind protein	0.0138	0.6561	0.6561
Onchocerca volvulus		0.0114	0.5339	0.6674
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	serpin	0.0014	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Onchocerca volvulus		0.0023	0.0834	0.1042
Brugia malayi	G-protein coupled receptor	0.0114	0.5339	0.5339
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0207	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0114	0.5339	0.5339
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	serine protease inhibitor	0.0014	0.0367	0.0367
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0114	0.5339	0.5339
Echinococcus granulosus	Estrogen regulated protein EP45	0.0014	0.0367	0.0367
Onchocerca volvulus		0.0114	0.5339	0.6674
Brugia malayi	serpin	0.0014	0.0367	0.0367
Onchocerca volvulus		0.0114	0.5339	0.6674
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0114	0.5339	0.5339
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0114	0.5339	0.5339
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0023	0.0834	0.0834
Echinococcus multilocularis	aldo keto reductase	0.0023	0.0834	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Onchocerca volvulus		0.0114	0.5339	0.6674
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0114	0.5339	0.5339
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0023	0.0834	0.0834
Schistosoma mansoni	hypothetical protein	0.0114	0.5339	0.5339
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0114	0.5339	0.5339
Brugia malayi	larval opioid receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	segment polarity protein dishevelled	0.0008	0.007	0.007
Echinococcus granulosus	aldo keto reductase	0.0023	0.0834	0.0834
Brugia malayi	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	putative neuropeptide receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	opsin-like receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	neuropeptide Y receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.161	0.161
Schistosoma mansoni	amine GPCR	0.0114	0.5339	0.5339
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0114	0.5339	0.6674
Loa Loa (eye worm)	hypothetical protein	0.0008	0.007	0.007
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0023	0.0834	0.0834
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0114	0.5339	0.5339
Toxoplasma gondii	aldose reductase, putative	0.0023	0.0834	0.0834
Schistosoma mansoni	neuropeptide receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	biogenic amine receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0023	0.0834	0.0834
Brugia malayi	hypothetical protein	0.0114	0.5339	0.5339
Schistosoma mansoni	neuropeptide receptor	0.0114	0.5339	0.5339
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0008	0.007	0.0088
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0114	0.5339	0.5339
Echinococcus granulosus	g-protein coupled receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	allatostatin A receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0114	0.5339	0.5339
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0023	0.0834	0.0834
Brugia malayi	Muscleblind-like protein	0.0138	0.6561	0.6561
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	fmrfamide receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	tm gpcr rhodopsin	0.0114	0.5339	0.5339
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0114	0.5339	0.5339
Echinococcus multilocularis	neuropeptide Y receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	serine protease inhibitor	0.0014	0.0367	0.0367
Echinococcus granulosus	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Brugia malayi	hypothetical protein	0.0008	0.007	0.007
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0114	0.5339	0.5339
Onchocerca volvulus		0.0023	0.0834	0.1042
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0023	0.0834	0.0834
Onchocerca volvulus		0.0014	0.0367	0.0459
Onchocerca volvulus		0.0114	0.5339	0.6674
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	hypothetical protein	0.0008	0.007	0.007
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0138	0.6561	0.6561
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0023	0.0834	0.0834
Schistosoma mansoni	serine protease inhibitors serpins	0.0014	0.0367	0.0367
Schistosoma mansoni	amine GPCR	0.0114	0.5339	0.5339
Onchocerca volvulus		0.0114	0.5339	0.6674
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0114	0.5339	0.5339
Giardia lamblia	Aldose reductase	0.0023	0.0834	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0039	0.161	0.161
Schistosoma mansoni	hypothetical protein	0.0114	0.5339	0.5339
Schistosoma mansoni	neuropeptide F-like receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0834	0.0834
Brugia malayi	ORL1-like opioid receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0367	0.0367
Echinococcus granulosus	neuropeptides capa receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	neuropeptide receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	serine protease inhibitor	0.0014	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	DIX domain containing protein	0.0008	0.007	0.007
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0114	0.5339	0.5339
Brugia malayi	Serotonin receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	regulator of G protein signaling 7	0.0008	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0167	0.8	0.8
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0207	1	1
Echinococcus granulosus	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0114	0.5339	0.5339
Schistosoma mansoni	z-protein (S1r protein)	0.0008	0.007	0.007
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0023	0.0834	0.0834
Entamoeba histolytica	aldose reductase, putative	0.0023	0.0834	0.0834
Schistosoma mansoni	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus multilocularis	neuropeptide receptor A26	0.0114	0.5339	0.5339
Echinococcus multilocularis	regulator of G protein signaling 7	0.0008	0.007	0.007
Loa Loa (eye worm)	serpin protein 6	0.0014	0.0367	0.0367
Onchocerca volvulus		0.0023	0.0834	0.1042
Brugia malayi	serpin precursor	0.0014	0.0367	0.0367
Trypanosoma cruzi	aldo/keto reductase, putative	0.0023	0.0834	0.0834
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0114	0.5339	0.5339
Echinococcus multilocularis	neuropeptide receptor	0.0114	0.5339	0.5339
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0023	0.0834	0.0834
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0023	0.0834	0.0834
Brugia malayi	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0023	0.0834	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus multilocularis	muscleblind protein 1	0.0138	0.6561	0.6561
Onchocerca volvulus		0.0114	0.5339	0.6674
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	G-protein coupled receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0023	0.0834	0.0834
Echinococcus granulosus	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	neuropeptide receptor	0.0114	0.5339	0.5339
Trypanosoma brucei	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Onchocerca volvulus		0.0114	0.5339	0.6674
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0114	0.5339	0.5339
Loa Loa (eye worm)	serpin	0.0014	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0023	0.0834	0.0834
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0207	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0114	0.5339	0.5339
Brugia malayi	Dopamine receptor protein 1	0.0114	0.5339	0.5339
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0008	0.007	0.007
Schistosoma mansoni	opsin-like receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	g protein coupled receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	neuropeptides capa receptor	0.0114	0.5339	0.5339
Brugia malayi	putative neuropeptide receptor NPR1	0.0114	0.5339	0.5339
Giardia lamblia	Aldose reductase	0.0023	0.0834	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0367	0.0367
Brugia malayi	Dopamine receptor protein 2	0.0114	0.5339	0.5339
Echinococcus multilocularis	orexin receptor type 2	0.0114	0.5339	0.5339
Schistosoma mansoni	serpin	0.0014	0.0367	0.0367
Echinococcus granulosus	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Echinococcus multilocularis	dro:myosuppressin receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	serine protease inhibitors serpins	0.0014	0.0367	0.0367
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0114	0.5339	0.5339
Echinococcus multilocularis	regulator of G protein signaling 7	0.0008	0.007	0.007
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0023	0.0834	0.0834
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0023	0.0834	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0367	0.0367
Onchocerca volvulus		0.0114	0.5339	0.6674
Echinococcus multilocularis	g protein coupled receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	neuropeptide s receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	aldo keto reductase	0.0023	0.0834	0.0834
Schistosoma mansoni	hypothetical protein	0.0114	0.5339	0.5339
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0114	0.5339	0.5339
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0023	0.0834	0.0834
Schistosoma mansoni	neuropeptide receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	aldo keto reductase	0.0023	0.0834	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0114	0.5339	0.5339
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0207	1	1
Echinococcus multilocularis	aldo keto reductase	0.0023	0.0834	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	BmSERPIN, truncated	0.0014	0.0367	0.0367
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0114	0.5339	0.5339
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0114	0.5339	0.5339
Schistosoma mansoni	biogenic amine receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	somatostatin receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	hypothetical protein	0.0023	0.0834	0.0834
Echinococcus multilocularis	neuropeptides capa receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	myosin xvIII	0.0114	0.5339	0.5339
Echinococcus granulosus	neuropeptide receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0367	0.0367
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0207	1	1
Trypanosoma brucei	prostaglandin f synthase	0.0023	0.0834	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0008	0.007	0.007
Echinococcus granulosus	segment polarity protein dishevelled	0.0008	0.007	0.007
Brugia malayi	serpin	0.0014	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Echinococcus multilocularis	g protein coupled receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	serpin	0.0014	0.0367	0.0367
Schistosoma mansoni	growth hormone secretagogue receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	G protein coupled receptor 139	0.0114	0.5339	0.5339
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0039	0.161	0.161
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	segment polarity protein dishevelled	0.0008	0.007	0.007
Brugia malayi	serpin	0.0014	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	Estrogen regulated protein EP45	0.0014	0.0367	0.0367
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Onchocerca volvulus		0.0023	0.0834	0.1042
Loa Loa (eye worm)	G-protein coupled receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0367	0.0367
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0023	0.0834	0.0834
Schistosoma mansoni	serine protease inhibitors serpins	0.0014	0.0367	0.0367
Onchocerca volvulus		0.0114	0.5339	0.6674
Echinococcus multilocularis	Estrogen regulated protein EP45	0.0014	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus granulosus	biogenic amine 5HT receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	g protein coupled receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	segment polarity protein dishevelled	0.0008	0.007	0.007
Onchocerca volvulus		0.0014	0.0367	0.0459
Schistosoma mansoni	aldo-keto reductase	0.0023	0.0834	0.0834
Brugia malayi	serpin (BmSERPIN)	0.0014	0.0367	0.0367
Schistosoma mansoni	aldo-keto reductase	0.0023	0.0834	0.0834
Brugia malayi	serpin (BmSERPIN)	0.0014	0.0367	0.0367
Loa Loa (eye worm)	oxidoreductase	0.0023	0.0834	0.0834
Echinococcus multilocularis	serotonin receptor	0.0114	0.5339	0.5339
Trichomonas vaginalis	aldo/keto reductase, putative	0.0023	0.0834	0.0834
Echinococcus granulosus	g protein coupled receptor	0.0114	0.5339	0.5339
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0008	0.007	0.007
Brugia malayi	serpin	0.0014	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Schistosoma mansoni	amine GPCR	0.0114	0.5339	0.5339
Echinococcus multilocularis	serine protease inhibitor	0.0014	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	serpin	0.0014	0.0367	0.0367
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0023	0.0834	0.0834
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0114	0.5339	0.5339
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0023	0.0834	0.0834
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0207	1	1
Mycobacterium leprae	Conserved hypothetical protein	0.0017	0.0494	0.5922
Schistosoma mansoni	serine protease inhibitors serpins	0.0014	0.0367	0.0367
Schistosoma mansoni	dep domain containing protein	0.0008	0.007	0.007
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0207	1	1
Echinococcus granulosus	plasminogen activator inhibitor 2	0.0014	0.0367	0.0367
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0023	0.0834	0.0834
Onchocerca volvulus		0.0114	0.5339	0.6674
Onchocerca volvulus		0.0023	0.0834	0.1042
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0207	1	1
Onchocerca volvulus		0.0114	0.5339	0.6674
Echinococcus granulosus	regulator of G protein signaling 7	0.0008	0.007	0.007
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0023	0.0834	0.0834
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0008	0.007	0.007
Leishmania major	aldo-keto reductase-like protein	0.0023	0.0834	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0023	0.0834	0.0834
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0023	0.0834	0.0834
Echinococcus granulosus	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Loa Loa (eye worm)	oxidoreductase	0.0023	0.0834	0.0834
Brugia malayi	Melatonin receptor type 1A	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0023	0.0834	0.0834
Brugia malayi	serpin	0.0014	0.0367	0.0367
Onchocerca volvulus		0.0023	0.0834	0.1042
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	g-protein coupled receptor	0.0114	0.5339	0.5339
Echinococcus multilocularis	muscleblind protein	0.0138	0.6561	0.6561
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.161	0.161
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0114	0.5339	0.5339
Echinococcus granulosus	orexin receptor type 2	0.0114	0.5339	0.5339
Schistosoma mansoni	dishevelled	0.0008	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0138	0.6561	0.6561
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0114	0.5339	0.5339
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0114	0.5339	0.5339
Schistosoma mansoni	amine GPCR	0.0114	0.5339	0.5339
Schistosoma mansoni	dishevelled	0.0008	0.007	0.007
Loa Loa (eye worm)	oxidoreductase	0.0023	0.0834	0.0834
Echinococcus granulosus	biogenic amine 5HT receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	neuropeptides capa receptor	0.0114	0.5339	0.5339
Brugia malayi	BmSERPIN	0.0014	0.0367	0.0367
Brugia malayi	N-terminal motif family protein	0.0167	0.8	0.8
Echinococcus multilocularis	aldo keto reductase	0.0023	0.0834	0.0834
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0114	0.5339	0.6674
Echinococcus granulosus	neuropeptide FF receptor 2	0.0114	0.5339	0.5339
Loa Loa (eye worm)	DIX domain-containing protein	0.0008	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0367	0.0367
Onchocerca volvulus		0.0008	0.007	0.0088
Echinococcus multilocularis	neuropeptide s receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Schistosoma mansoni	biogenic amine receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0114	0.5339	0.5339
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0039	0.161	0.161
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0039	0.161	0.161
Schistosoma mansoni	neuropeptide receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0114	0.5339	0.5339
Echinococcus multilocularis	fmrfamide receptor	0.0114	0.5339	0.5339
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0207	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0114	0.5339	0.5339
Echinococcus granulosus	G protein coupled receptor 139	0.0114	0.5339	0.5339
Schistosoma mansoni	serine protease inhibitors serpins	0.0014	0.0367	0.0367
Brugia malayi	regulator of G-protein signaling egl-10	0.0008	0.007	0.007
Echinococcus multilocularis	fmrfamide receptor	0.0114	0.5339	0.5339
Schistosoma mansoni	regulator of G protein signaling	0.0008	0.007	0.007
Echinococcus multilocularis	allatostatin A receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	aldehyde reductase	0.0017	0.0494	0.0494
Brugia malayi	neuropeptide F receptor	0.0114	0.5339	0.5339
Echinococcus granulosus	7tm_1 domain containing protein	0.0114	0.5339	0.5339
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0023	0.0834	0.0834
Echinococcus granulosus	tm gpcr rhodopsin	0.0114	0.5339	0.5339
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0023	0.0834	0.0834
Brugia malayi	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0114	0.5339	0.5339
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0114	0.5339	0.5339
Brugia malayi	G protein-coupled receptor F59B2.13	0.0114	0.5339	0.5339
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0114	0.5339	0.5339
Schistosoma mansoni	serpin	0.0014	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0008	0.007	0.007
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0008	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0114	0.5339	0.5339
Loa Loa (eye worm)	G-protein coupled receptor	0.0114	0.5339	0.5339
Toxoplasma gondii	hypothetical protein	0.0008	0.007	0.007
Loa Loa (eye worm)	oxidoreductase	0.0023	0.0834	0.0834
Brugia malayi	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Trichomonas vaginalis	aldo-keto reductase, putative	0.0023	0.0834	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0114	0.5339	0.5339
Brugia malayi	neuropeptide F receptor	0.0114	0.5339	0.5339

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2260678

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1841254