Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase | 0.008 | 0.4285 | 0.4779 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0055 | 0.2269 | 0.2792 |
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.008 | 0.4285 | 0.5273 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1344 | 0.0782 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0128 | 0.8127 | 0.7802 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.008 | 0.4285 | 0.5273 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1476 | 0.181 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0128 | 0.8127 | 0.5 |
Echinococcus granulosus | expressed conserved protein | 0.0099 | 0.5825 | 0.5102 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0045 | 0.1476 | 0.181 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0128 | 0.8127 | 1 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.008 | 0.4285 | 0.5255 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0046 | 0.1497 | 0.1842 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0055 | 0.2269 | 0.0931 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0055 | 0.2269 | 0.2792 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.6342 | 0.7777 |
Schistosoma mansoni | patched 1 | 0.0045 | 0.1476 | 0.0962 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2134 | 0.2617 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2269 | 0.1193 |
Plasmodium vivax | RNA helicase-1, putative | 0.0128 | 0.8127 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0128 | 0.8127 | 0.7802 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0128 | 0.8127 | 0.7802 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0055 | 0.2269 | 0.204 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.8127 | 0.9966 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0107 | 0.6474 | 0.7754 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2299 | 0.2819 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0128 | 0.8127 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.8154 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0768 | 0.0942 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0055 | 0.2269 | 0.0931 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0055 | 0.2269 | 0.0931 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0128 | 0.8127 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0128 | 0.8127 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0128 | 0.8127 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.2134 | 0.2617 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2269 | 0.1193 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.2617 | 0.3209 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0106 | 0.6342 | 0.7777 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.1497 | 0.1836 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.2617 | 0.3209 |
Brugia malayi | Cytochrome P450 family protein | 0.0046 | 0.1497 | 0.1836 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1344 | 0.0782 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.2134 | 0.2617 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0128 | 0.8127 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.008 | 0.4285 | 0.5273 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0128 | 0.8127 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0046 | 0.1497 | 0.1836 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1344 | 0.0782 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0128 | 0.8127 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0128 | 0.8127 | 0.9966 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0128 | 0.8127 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.2269 | 0.2792 |
Trichomonas vaginalis | STE family protein kinase | 0.008 | 0.4285 | 0.4224 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0128 | 0.8127 | 1 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.008 | 0.4285 | 0.3296 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0128 | 0.8127 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0055 | 0.2269 | 0.2792 |
Trichomonas vaginalis | STE family protein kinase | 0.008 | 0.4285 | 0.4224 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0046 | 0.1497 | 0.1842 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0055 | 0.2269 | 0.2792 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0055 | 0.2269 | 0.2783 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.8154 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0128 | 0.8127 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.008 | 0.4285 | 0.3296 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0046 | 0.1497 | 0.1836 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0128 | 0.8127 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2269 | 0.1193 |
Giardia lamblia | Kinase, STE STE20 | 0.008 | 0.4285 | 0.3441 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0151 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0046 | 0.1497 | 0.1842 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0128 | 0.8127 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.2269 | 0.2792 |
Brugia malayi | MAP kinase sur-1 | 0.0055 | 0.2269 | 0.2783 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2269 | 0.1193 |
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.008 | 0.4285 | 0.5255 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0768 | 0.0942 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0128 | 0.8127 | 0.7802 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0055 | 0.2269 | 0.2792 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.8154 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0002 | 0.0002 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0128 | 0.8127 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0046 | 0.1497 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0055 | 0.2269 | 0.0931 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0106 | 0.6342 | 0.5709 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0055 | 0.2269 | 0.2792 |
Echinococcus multilocularis | expressed conserved protein | 0.0099 | 0.5825 | 0.5102 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.1497 | 0.1836 |
Brugia malayi | CHE-14 protein | 0.0045 | 0.1476 | 0.181 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1344 | 0.0782 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0128 | 0.8127 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0106 | 0.6342 | 0.5709 |
Leishmania major | cytochrome p450-like protein | 0.0046 | 0.1497 | 0.1842 |
Echinococcus multilocularis | protein dispatched 1 | 0.0052 | 0.1993 | 0.0606 |
Trypanosoma brucei | protein kinase, putative | 0.0055 | 0.2269 | 0.2792 |
Trichomonas vaginalis | STE family protein kinase | 0.008 | 0.4285 | 0.4224 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.2134 | 0.2617 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9 nM | In vitro inhibition of potassium-contracted rabbit aorta strips | ChEMBL. | 1387168 |
Max/average (functional) | = 0 | In vivo evaluation for the antihypertensive effect in the spontaneously hypertensive rat is % decrease in blood pressure during post drug administration at 135 umol/kg peroral; 50/50 | ChEMBL. | 1387168 |
Max/average (functional) | = 0 | In vivo evaluation for the antihypertensive effect in the spontaneously hypertensive rat is % decrease in blood pressure during post drug administration at 45 umol/kg peroral; 42/41 | ChEMBL. | 1387168 |
Max/average (functional) | = 0 | In vivo evaluation for the antihypertensive effect in the spontaneously hypertensive rat is % decrease in blood pressure during post drug administration at 15 uM/kg peroral; 38/33 | ChEMBL. | 1387168 |
Max/average (functional) | = 0 | In vivo evaluation for the antihypertensive effect in the spontaneously hypertensive rat is % decrease in blood pressure during post drug administration at 5 umol/kg peroral; 21/20 | ChEMBL. | 1387168 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.