Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ras-related protein ypt4 | 0.0031 | 0.0187 | 0.0188 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0729 | 0.9931 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.0187 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0031 | 0.0187 | 1 |
Trypanosoma brucei | Rab-like 5, small G protein | 0.0031 | 0.0187 | 1 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0729 | 0.9931 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0031 | 0.0187 | 1 |
Echinococcus granulosus | rab protein 3 | 0.0031 | 0.0187 | 0.0187 |
Onchocerca volvulus | 0.0031 | 0.0187 | 1 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0359 | 0.4761 | 0.4794 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | Mitochondrial Rho GTPase homolog | 0.0031 | 0.0187 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0187 | 0.0188 |
Leishmania major | hypothetical protein, conserved | 0.0031 | 0.0187 | 1 |
Plasmodium falciparum | ras-related protein Rab-5A | 0.0031 | 0.0187 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0031 | 0.0187 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0187 | 0.0188 |
Brugia malayi | hypothetical protein | 0.0031 | 0.0187 | 0.0188 |
Echinococcus multilocularis | rab protein 3 | 0.0031 | 0.0187 | 0.0188 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0359 | 0.4761 | 0.4794 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0359 | 0.4761 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0359 | 0.4761 | 0.4794 |
Brugia malayi | Protein kinase domain containing protein | 0.0729 | 0.9931 | 1 |
Trichomonas vaginalis | GTP binding protein rare7l, putative | 0.0031 | 0.0187 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0187 | 0.0392 |
Echinococcus granulosus | GTP binding protein Parf | 0.0031 | 0.0187 | 0.0187 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0031 | 0.0187 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0359 | 0.4761 | 0.4761 |
Plasmodium vivax | ras-related protein Rab-5A, putative | 0.0031 | 0.0187 | 0.5 |
Echinococcus multilocularis | GTP binding protein Parf | 0.0031 | 0.0187 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0187 | 0.0188 |
Trypanosoma cruzi | Rab-like 5, small G protein | 0.0031 | 0.0187 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.0187 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0031 | 0.0187 | 1 |
Echinococcus multilocularis | ras-related protein rab-5 | 0.0031 | 0.0187 | 0.0188 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.0187 | 1 |
Brugia malayi | RAB, member of RAS oncogene family-like 5 | 0.0031 | 0.0187 | 0.0188 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0 % | Phytotoxicity against directly seeded Oryza sativa (rice) seedlings assessed as phytotoxic activity ratings (0- no effect to 5-complete killing rating scale) at 100 g/a measured after 3 weeks post compound treatment under green house conditions | ChEMBL. | 27393589 |
Activity (ADMET) | = 100 % | Effect on Oryza sativa (rice) assessed as growth rate at 1 uM relative to control | ChEMBL. | 27393060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.