TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 340.502 | Formula: C22H32N2O
H donors: 2 H acceptors: 2 LogP: 4.1 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: OC1CC[C@]2(C(=CCC3C2CC[C@]2(C3CC[C@@H]2c2nc[nH]c2)C)C1)C
InChi: 1S/C22H32N2O/c1-21-9-7-15(25)11-14(21)3-4-16-17-5-6-19(20-12-23-13-24-20)22(17,2)10-8-18(16)21/h3,12-13,15-19,25H,4-11H2,1-2H3,(H,23,24)/t15?,16?,17?,18?,19-,21+,22+/m1/s1
InChiKey: BBUJYEQSYYZBDG-LUECPEOQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0494	0.0214	0.0209
Echinococcus granulosus	serotonin receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	biogenic amine receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	neuropeptide Y receptor	0.0121	0.0034	0.003
Echinococcus granulosus	neuropeptides capa receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	G protein coupled receptor 139	0.0121	0.0034	0.003
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0121	0.0034	0.003
Schistosoma mansoni	biogenic amine receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0006	0.0002
Brugia malayi	follicle stimulating hormone receptor	0.0121	0.0034	0.0034
Onchocerca volvulus		0.0121	0.0034	0.4264
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.7311	0.3488	0.3485
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0143	0.0045	0.4725
Echinococcus granulosus	neuropeptide s receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus multilocularis	fmrfamide receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0121	0.0034	0.003
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0121	0.0034	0.003
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.007	0.001	0.0006
Schistosoma mansoni	hypothetical protein	0.0306	0.0123	0.0119
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0104	0.0026	0.1571
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0006	0.0002
Toxoplasma gondii	hypothetical protein	0.0351	0.0145	1
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0104	0.0026	0.081
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0121	0.0034	0.003
Brugia malayi	Dopamine receptor protein 1	0.0121	0.0034	0.0034
Echinococcus multilocularis	neuropeptide receptor	0.0121	0.0034	0.003
Onchocerca volvulus		0.007	0.001	0.0788
Echinococcus multilocularis	neuropeptide Y receptor	0.0121	0.0034	0.003
Echinococcus granulosus	7TM GPCR rhodopsin	0.0121	0.0034	0.003
Brugia malayi	RNA binding protein	0.0063	0.0006	0.0006
Onchocerca volvulus		0.0121	0.0034	0.4264
Schistosoma mansoni	cathepsin D (A01 family)	0.014	0.0044	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus granulosus	neuropeptide receptor	0.0121	0.0034	0.003
Schistosoma mansoni	hypothetical protein	0.0168	0.0057	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0075	0.0075
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0104	0.0026	0.2213
Mycobacterium ulcerans	aminopeptidase N PepN	0.007	0.001	0.5
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.007	0.001	0.0695
Brugia malayi	neuropeptide F receptor	0.0121	0.0034	0.0034
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Loa Loa (eye worm)	aminopeptidase N	0.007	0.001	0.001
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0225	0.0084	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0121	0.0034	0.003
Echinococcus granulosus	neuropeptide receptor A26	0.0121	0.0034	0.003
Schistosoma mansoni	neuropeptide receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0121	0.0034	0.003
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0143	0.0045	0.5092
Onchocerca volvulus		0.0121	0.0034	0.4264
Schistosoma mansoni	amine GPCR	0.0121	0.0034	0.003
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0121	0.0034	0.0034
Brugia malayi	Dopamine receptor protein 2	0.0121	0.0034	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.0034	0.003
Trypanosoma cruzi	hypothetical protein, conserved	0.0143	0.0045	0.5092
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0225	0.0084	0.3658
Onchocerca volvulus		0.0143	0.0045	0.5773
Echinococcus granulosus	tm gpcr rhodopsin	0.0121	0.0034	0.003
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0006	0.0002
Echinococcus granulosus	neuropeptide Y receptor	0.0121	0.0034	0.003
Trypanosoma cruzi	Aminopeptidase M1, putative	0.007	0.001	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0104	0.0026	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Onchocerca volvulus		0.0121	0.0034	0.4264
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0121	0.0034	0.003
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0121	0.0034	0.003
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0143	0.0045	0.1728
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0225	0.0084	0.008
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0121	0.0034	0.003
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0436	0.0186	0.0181
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0143	0.0045	0.0041
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0121	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Brugia malayi	Peptidase family M1 containing protein	0.007	0.001	0.001
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0225	0.0084	0.0084
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0225	0.0084	0.3826
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0494	0.0214	0.0209
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.0034	0.003
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0121	0.0034	0.0034
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0143	0.0045	0.5092
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0143	0.0045	0.1948
Echinococcus granulosus	7tm_1 domain containing protein	0.0121	0.0034	0.003
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.007	0.001	0.0006
Echinococcus multilocularis	g protein coupled receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0143	0.0045	0.0045
Schistosoma mansoni	hypothetical protein	0.0121	0.0034	0.003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0121	0.0034	0.0034
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0121	0.0034	0.003
Echinococcus granulosus	g protein coupled receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus granulosus	g protein coupled receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0004	0.0004
Onchocerca volvulus		0.0121	0.0034	0.4264
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Schistosoma mansoni	amine GPCR	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.0034	0.003
Schistosoma mansoni	neuropeptide receptor	0.0121	0.0034	0.003
Trypanosoma cruzi	hypothetical protein, conserved	0.0104	0.0026	0.2755
Echinococcus multilocularis	g-protein coupled receptor	0.0121	0.0034	0.003
Echinococcus granulosus	biogenic amine 5HT receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	somatostatin receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	allatostatin A receptor	0.0121	0.0034	0.003
Brugia malayi	TAR-binding protein	0.0063	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus multilocularis	serotonin receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	aminopeptidase N	0.0154	0.005	0.0046
Brugia malayi	Serotonin receptor	0.0121	0.0034	0.0034
Brugia malayi	Melatonin receptor type 1A	0.0121	0.0034	0.0034
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0436	0.0186	0.8627
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0436	0.0186	0.0181
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.0034	0.003
Brugia malayi	hypothetical protein	0.0121	0.0034	0.0034
Trypanosoma cruzi	lanosterol synthase, putative	0.015	0.0048	0.5492
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0494	0.0214	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0121	0.0034	0.003
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0143	0.0045	0.5092
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0121	0.0034	0.003
Plasmodium vivax	geranylgeranyltransferase, putative	0.0104	0.0026	0.1054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0143	0.0045	0.1728
Loa Loa (eye worm)	TK/ROR protein kinase	0.0058	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	neuropeptide f receptor 76f	0.0121	0.0034	0.003
Brugia malayi	sulfakinin receptor protein	0.0121	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus granulosus	somatostatin receptor	0.0121	0.0034	0.003
Onchocerca volvulus		0.0154	0.005	0.6496
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0104	0.0026	0.2755
Onchocerca volvulus		0.0121	0.0034	0.4264
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Trypanosoma cruzi	aminopeptidase, putative	0.007	0.001	0.0695
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0205	0.0075	0.0071
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0104	0.0026	0.0026
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0225	0.0084	0.008
Echinococcus multilocularis	g protein coupled receptor	0.0121	0.0034	0.003
Brugia malayi	RE15519p	0.0121	0.0034	0.0034
Loa Loa (eye worm)	melatonin receptor type 1A	0.0121	0.0034	0.0034
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	0.0123	0.0123
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0225	0.0084	0.3658
Schistosoma mansoni	neuropeptide F-like receptor	0.0121	0.0034	0.003
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0121	0.0034	0.003
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0121	0.0034	0.0034
Echinococcus multilocularis	neuropeptides capa receptor	0.0121	0.0034	0.003
Leishmania major	geranylgeranyltransferase, putative	0.0104	0.0026	0.2755
Echinococcus granulosus	neuropeptide receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0205	0.0075	0.0071
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0004	0.0004
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.0086	1
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	2.0871	1	1
Schistosoma mansoni	neuropeptide receptor	0.0121	0.0034	0.003
Echinococcus granulosus	tm gpcr rhodopsin	0.7311	0.3488	0.3485
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0026	0.0026
Echinococcus granulosus	sex peptide receptor	0.0121	0.0034	0.003
Schistosoma mansoni	myosin xvIII	0.0121	0.0034	0.003
Echinococcus granulosus	orexin receptor type 2	0.0121	0.0034	0.003
Echinococcus granulosus	g protein coupled receptor	0.0121	0.0034	0.003
Schistosoma mansoni	amine GPCR	0.0121	0.0034	0.003
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0121	0.0034	0.4264
Loa Loa (eye worm)	hypothetical protein	0.0494	0.0214	0.0214
Onchocerca volvulus		0.0121	0.0034	0.4264
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0006	0.0002
Echinococcus granulosus	tm gpcr rhodopsin	0.0121	0.0034	0.003
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0121	0.0034	0.003
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0225	0.0084	0.0084
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.007	0.001	0.0006
Echinococcus granulosus	fmrfamide receptor	0.0121	0.0034	0.003
Schistosoma mansoni	amine GPCR	0.0121	0.0034	0.003
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0121	0.0034	0.003
Schistosoma mansoni	hypothetical protein	0.0121	0.0034	0.003
Echinococcus granulosus	G protein coupled receptor 139	0.0121	0.0034	0.003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Echinococcus multilocularis	dro:myosuppressin receptor	0.0121	0.0034	0.003
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0436	0.0186	0.0186
Onchocerca volvulus		0.0121	0.0034	0.4264
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Loa Loa (eye worm)	neuropeptide F receptor	0.0121	0.0034	0.0034
Echinococcus multilocularis	orexin receptor type 2	0.0121	0.0034	0.003
Brugia malayi	putative neuropeptide receptor NPR1	0.0121	0.0034	0.0034
Onchocerca volvulus		0.0121	0.0034	0.4264
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0436	0.0186	0.0186
Loa Loa (eye worm)	G-protein coupled receptor	0.0121	0.0034	0.0034
Echinococcus granulosus	aminopeptidase N	0.0154	0.005	0.0046
Giardia lamblia	Rab geranylgeranyltransferase	0.0494	0.0214	1
Brugia malayi	neuropeptide F receptor	0.0121	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0075	0.0075
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0109	0.0028	0.0028
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0121	0.0034	0.003
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.007	0.001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	2.0871	1	1
Echinococcus granulosus	snurportin 1	0.0306	0.0123	0.0119
Echinococcus granulosus	neuropeptides capa receptor	0.0121	0.0034	0.003
Brugia malayi	G-protein coupled receptor	0.0121	0.0034	0.0034
Schistosoma mansoni	histamine h1 receptor	0.0121	0.0034	0.003
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.007	0.001	0.0695
Onchocerca volvulus		0.0205	0.0075	1
Brugia malayi	ORL1-like opioid receptor	0.0121	0.0034	0.0034
Brugia malayi	Serotonin receptor	0.0121	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0121	0.0034	0.0034
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0225	0.0084	0.5702
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0225	0.0084	0.3658
Brugia malayi	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.007	0.001	0.0006
Schistosoma mansoni	hypothetical protein	0.0121	0.0034	0.003
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Loa Loa (eye worm)	G-protein coupled receptor	0.0121	0.0034	0.0034
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0121	0.0034	0.003
Brugia malayi	AKH receptor	0.0121	0.0034	0.0034
Giardia lamblia	Rab geranylgeranyltransferase	0.0143	0.0045	0.1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0006	0.0006
Toxoplasma gondii	hypothetical protein	0.0143	0.0045	0.2903
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0006	0.0006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Brugia malayi	hypothetical protein	0.007	0.001	0.001
Echinococcus multilocularis	geminin	0.0168	0.0057	0.0053
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.007	0.001	0.0006
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.007	0.001	0.0006
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0104	0.0026	0.0022
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0143	0.0045	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	hypothetical protein	0.0168	0.0057	0.0053
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0121	0.0034	0.0034
Echinococcus granulosus	neuropeptide FF receptor 2	0.0121	0.0034	0.003
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0225	0.0084	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0121	0.0034	0.003
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0494	0.0214	1
Echinococcus multilocularis	snurportin 1	0.0306	0.0123	0.0119
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0143	0.0045	0.4725
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Trypanosoma brucei	hypothetical protein, conserved	0.0143	0.0045	0.4725
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0121	0.0034	0.0034
Brugia malayi	larval opioid receptor	0.0121	0.0034	0.0034
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0121	0.0034	0.003
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0494	0.0214	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0121	0.0034	0.003
Echinococcus granulosus	g-protein coupled receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0121	0.0034	0.003
Echinococcus granulosus	hypothetical protein	0.0121	0.0034	0.003
Schistosoma mansoni	opsin-like receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0494	0.0214	0.0209
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0006	0.0002
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0121	0.0034	0.003
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0143	0.0045	0.0041
Brugia malayi	Kringle domain containing protein	0.0058	0.0004	0.0004
Loa Loa (eye worm)	TYRA-2 protein	0.0121	0.0034	0.0034
Loa Loa (eye worm)	neuropeptide F receptor	0.0121	0.0034	0.0034
Trypanosoma cruzi	hypothetical protein, conserved	0.0143	0.0045	0.5092
Loa Loa (eye worm)	hypothetical protein	2.0871	1	1
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0225	0.0084	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0026	0.0026
Brugia malayi	GnHR receptor homolog	0.0121	0.0034	0.0034
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0121	0.0034	0.003
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0121	0.0034	0.0034
Trypanosoma brucei	lanosterol synthase	0.015	0.0048	0.5155
Onchocerca volvulus		0.018	0.0063	0.8252
Brugia malayi	Dopamine receptor	0.0121	0.0034	0.0034
Echinococcus multilocularis	serotonin receptor	0.0121	0.0034	0.003
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0121	0.0034	0.003
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0104	0.0026	0.0022
Schistosoma mansoni	adenoreceptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Onchocerca volvulus		0.0121	0.0034	0.4264
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Onchocerca volvulus		0.0121	0.0034	0.4264
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0121	0.0034	0.003
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0494	0.0214	1
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0225	0.0084	0.3658
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0121	0.0034	0.003
Onchocerca volvulus		0.0121	0.0034	0.4264
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0494	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Brugia malayi	Trypsin family protein	0.0205	0.0075	0.0075
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0225	0.0084	0.3826
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0104	0.0026	0.1054
Brugia malayi	G protein-coupled receptor F59B2.13	0.0121	0.0034	0.0034
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0121	0.0034	0.003
Echinococcus granulosus	geminin	0.0168	0.0057	0.0053
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0436	0.0186	0.0181
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0104	0.0026	0.081
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	sex peptide receptor	0.0121	0.0034	0.003
Echinococcus granulosus	neuropeptide Y receptor	0.0121	0.0034	0.003
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0143	0.0045	0.0045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.0034	0.003
Echinococcus granulosus	biogenic amine 5HT receptor	0.0121	0.0034	0.003
Schistosoma mansoni	neuropeptide F-like receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	neuropeptide receptor A26	0.0121	0.0034	0.003
Trypanosoma cruzi	lanosterol synthase, putative	0.015	0.0048	0.5492
Schistosoma mansoni	hypothetical protein	0.0121	0.0034	0.003
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0225	0.0084	0.3658
Brugia malayi	Peptidase family M1 containing protein	0.0154	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0006	0.0006
Echinococcus multilocularis	neuropeptides capa receptor	0.0121	0.0034	0.003
Onchocerca volvulus		0.0121	0.0034	0.4264
Echinococcus multilocularis	neuropeptide s receptor	0.0121	0.0034	0.003
Trypanosoma cruzi	hypothetical protein, conserved	0.0104	0.0026	0.2755
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.0034	0.003
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0121	0.0034	0.003
Echinococcus granulosus	allatostatin A receptor	0.0121	0.0034	0.003
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0006	0.0002
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.007	0.001	0.0695
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0104	0.0026	0.1571
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0104	0.0026	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0225	0.0084	0.008
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0436	0.0186	0.0181
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Brugia malayi	G protein-coupled receptor	0.0121	0.0034	0.0034
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0121	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	growth hormone secretagogue receptor	0.0121	0.0034	0.003
Giardia lamblia	Prenyltransferase	0.0225	0.0084	0.3099
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0121	0.0034	0.4264
Echinococcus multilocularis	g protein coupled receptor	0.0121	0.0034	0.003
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0121	0.0034	0.003
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.007	0.001	0.0006
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.007	0.001	0.0006
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0143	0.0045	0.0041
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0143	0.0045	0.0041
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0494	0.0214	0.0214
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0494	0.0214	1
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0143	0.0045	0.4725
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Schistosoma mansoni	cathepsin D (A01 family)	0.014	0.0044	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Onchocerca volvulus		0.0121	0.0034	0.4264
Schistosoma mansoni	amine GPCR	0.0121	0.0034	0.003
Schistosoma mansoni	neuropeptide receptor	0.0121	0.0034	0.003
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0096	0.0022	0.0018
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0121	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	opsin-like receptor	0.0121	0.0034	0.003
Brugia malayi	RNA, U transporter 1	0.0081	0.0015	0.0015
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0436	0.0186	0.8627
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.0034	0.003
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0121	0.0034	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	biogenic amine receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0121	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0121	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0006	0.0002
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0225	0.0084	0.3658
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0104	0.0026	0.081
Onchocerca volvulus		0.0121	0.0034	0.4264
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0121	0.0034	0.003
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.007	0.001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0143	0.0045	0.5092
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	2.0871	1	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Leishmania major	farnesyltransferase beta subunit	0.0225	0.0084	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.007	0.001	0.0006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0121	0.0034	0.003
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0351	0.0145	0.6621
Schistosoma mansoni	opsin-like receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Brugia malayi	putative neuropeptide receptor	0.0121	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0121	0.0034	0.0034
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0143	0.0045	0.1948
Echinococcus multilocularis	neuropeptide receptor	0.0121	0.0034	0.003
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0121	0.0034	0.003
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0494	0.0214	0.0214
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0225	0.0084	0.3658
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0121	0.0034	0.0034
Onchocerca volvulus		0.0121	0.0034	0.4264
Echinococcus granulosus	dro:myosuppressin receptor	0.0121	0.0034	0.003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0121	0.0034	0.003
Echinococcus multilocularis	fmrfamide receptor	0.0121	0.0034	0.003
Brugia malayi	G-protein coupled receptor	0.0121	0.0034	0.0034
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0121	0.0034	0.003
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0034	0.0034
Onchocerca volvulus		0.0121	0.0034	0.4264

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 66 nM	Inhibition of human testicular microsomal Cytochrome P450 17A1	ChEMBL.	9379450
IC50 (binding)	= 91 nM	Inhibition of rat testicular microsomal Cytochrome P450 17A1	ChEMBL.	9379450

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 283404

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 184238