Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0082 | 0.0134 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0029 | 0.0365 | 0.0599 |
Onchocerca volvulus | 0.0014 | 0.0082 | 0.2232 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0775 | 0.0715 |
Loa Loa (eye worm) | fibroinase | 0.0014 | 0.0082 | 0.0134 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0228 | 0.3947 | 0.6477 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0775 | 0.0715 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0347 | 0.6093 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0014 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0365 | 0.0599 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0775 | 0.0715 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0564 | 1 | 1 |
Brugia malayi | N-myristoyltransferase 2 | 0.0347 | 0.6093 | 1 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0347 | 0.6093 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0029 | 0.0365 | 1 |
Leishmania major | N-myristoyl transferase, putative | 0.0347 | 0.6093 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0347 | 0.6093 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0014 | 0.0082 | 0.0082 |
Brugia malayi | beta-lactamase | 0.0029 | 0.0365 | 0.0599 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Mycobacterium ulcerans | beta-lactamase | 0.0029 | 0.0365 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0347 | 0.6093 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0052 | 0.0775 | 0.1153 |
Onchocerca volvulus | 0.0014 | 0.0082 | 0.2232 | |
Loa Loa (eye worm) | ctsf protein | 0.0014 | 0.0082 | 0.0134 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0775 | 0.0715 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0775 | 0.0715 |
Giardia lamblia | CDC72 | 0.0347 | 0.6093 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0365 | 0.0599 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0029 | 0.0365 | 0.0286 |
Onchocerca volvulus | 0.0014 | 0.0082 | 0.2232 | |
Leishmania major | cathepsin L-like protease | 0.0052 | 0.0775 | 0.1153 |
Leishmania major | cathepsin L-like protease | 0.0052 | 0.0775 | 0.1153 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Onchocerca volvulus | 0.0014 | 0.0082 | 0.2232 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0014 | 0.0082 | 0.0134 |
Onchocerca volvulus | 0.0029 | 0.0365 | 1 | |
Mycobacterium ulcerans | lipase LipD | 0.0029 | 0.0365 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Loa Loa (eye worm) | cysteine protease | 0.0014 | 0.0082 | 0.0134 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0029 | 0.0365 | 0.0365 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0775 | 0.0715 |
Echinococcus granulosus | cathepsin l1 | 0.0014 | 0.0082 | 0.0082 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0347 | 0.6093 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0365 | 0.0472 |
Brugia malayi | beta-lactamase family protein | 0.0029 | 0.0365 | 0.0599 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0029 | 0.0365 | 0.0599 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Brugia malayi | beta-lactamase family protein | 0.0029 | 0.0365 | 0.0599 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0775 | 0.0715 |
Onchocerca volvulus | 0.0029 | 0.0365 | 1 | |
Loa Loa (eye worm) | beta-lactamase | 0.0029 | 0.0365 | 0.0599 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0188 | 0.3223 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0029 | 0.0365 | 0.0599 |
Mycobacterium leprae | Probable lipase LipE | 0.0029 | 0.0365 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.0365 | 1 | |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0041 | 0.0573 | 0.0818 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0775 | 0.0715 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0775 | 0.0715 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0029 | 0.0365 | 0.0599 |
Trichomonas vaginalis | esterase, putative | 0.0029 | 0.0365 | 0.0599 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0564 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0365 | 0.0472 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0029 | 0.0365 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0082 | 0.0134 |
Onchocerca volvulus | 0.0014 | 0.0082 | 0.2232 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0014 | 0.0082 | 0.0134 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0029 | 0.0365 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0347 | 0.6093 | 1 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0347 | 0.6093 | 0.6061 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0365 | 0.0599 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0365 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0365 | 0.0599 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0082 | 0.0134 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0052 | 0.0775 | 0.1153 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0082 | 0.0134 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0365 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0365 | 0.0599 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0014 | 0.0082 | 0.0134 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0052 | 0.0775 | 0.1153 |
Trypanosoma brucei | N-myristoyltransferase | 0.0347 | 0.6093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0365 | 0.0599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0052 | 0.0775 | 0.1153 |
Onchocerca volvulus | Cathepsin L homolog | 0.0014 | 0.0082 | 0.2232 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0082 | 0.0134 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0029 | 0.0365 | 0.0365 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0029 | 0.0365 | 0.0365 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0014 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0029 | 0.0365 | 0.0599 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0029 | 0.0365 | 0.0599 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0775 | 0.0715 |
Entamoeba histolytica | cysteine protease, putative | 0.0014 | 0.0082 | 0.0134 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0347 | 0.6093 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Leishmania major | cathepsin L-like protease | 0.0052 | 0.0775 | 0.1153 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0014 | 0.0082 | 0.0082 |
Mycobacterium leprae | conserved hypothetical protein | 0.0029 | 0.0365 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0082 | 0.2232 | |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0347 | 0.6093 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Onchocerca volvulus | Cathepsin L homolog | 0.0014 | 0.0082 | 0.2232 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Onchocerca volvulus | 0.0014 | 0.0082 | 0.2232 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0014 | 0.0082 | 0.0134 |
Mycobacterium ulcerans | hypothetical protein | 0.0029 | 0.0365 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0347 | 0.6093 | 0.6093 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0082 | 0.0134 |
Schistosoma mansoni | N-myristoyltransferase | 0.0347 | 0.6093 | 0.6093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0014 | 0.0082 | 0.0134 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0029 | 0.0365 | 0.0599 |
Onchocerca volvulus | Cathepsin F homolog | 0.0014 | 0.0082 | 0.2232 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0775 | 0.0715 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0048 | 0.0693 | 0.1017 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0082 | 0.0134 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.0082 | 0.0134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.