Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0203 | 0.8146 | 0.8146 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0014 | 0.0233 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0233 | 0.0277 |
Echinococcus granulosus | roundabout 2 | 0.0014 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0014 | 0.0233 | 0.0277 |
Echinococcus granulosus | hemicentin 1 | 0.0014 | 0.0233 | 0.0233 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0.1001 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase otk | 0.0014 | 0.0233 | 0.0233 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0233 | 0.0196 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0233 | 0.0196 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0.1001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0233 | 0.0277 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0233 | 0.0196 |
Echinococcus granulosus | roundabout 2 | 0.0014 | 0.0233 | 0.0233 |
Echinococcus multilocularis | hemicentin 1 | 0.0014 | 0.0233 | 0.0233 |
Echinococcus multilocularis | hemicentin 1 | 0.0014 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0233 | 0.0277 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0014 | 0.0233 | 0.0277 |
Echinococcus granulosus | contactin | 0.0014 | 0.0233 | 0.0233 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0233 | 0.0196 |
Echinococcus multilocularis | peroxidasin | 0.0014 | 0.0233 | 0.0233 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 1 | 1 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0233 | 0.0277 |
Echinococcus multilocularis | roundabout 2 | 0.0014 | 0.0233 | 0.0233 |
Echinococcus granulosus | roundabout 2 | 0.0014 | 0.0233 | 0.0233 |
Echinococcus granulosus | lachesin | 0.0014 | 0.0233 | 0.0233 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0014 | 0.0233 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0032 | 0.1001 | 0.1191 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.001 | 0.007 | 0.0083 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0014 | 0.0233 | 0.0233 |
Echinococcus multilocularis | roundabout 2 | 0.0014 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0014 | 0.0233 | 0.0277 |
Schistosoma mansoni | kinesin eg-5 | 0.0032 | 0.1001 | 0.0911 |
Echinococcus granulosus | peroxidasin | 0.0014 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | TK protein kinase | 0.0209 | 0.8399 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.8656 | 1 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0203 | 0.8146 | 0.8146 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0014 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0233 | 0.0277 |
Brugia malayi | Kinesin motor domain containing protein | 0.0032 | 0.1001 | 0.1117 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0032 | 0.1001 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0203 | 0.8146 | 0.9394 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0233 | 0.0196 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0233 | 0.0233 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0014 | 0.0233 | 0.0233 |
Brugia malayi | Peroxidasin | 0.0014 | 0.0233 | 0.0196 |
Echinococcus multilocularis | neurotracting:lsamp:neurotrimin:obcam | 0.0014 | 0.0233 | 0.0233 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0203 | 0.8146 | 0.8146 |
Echinococcus granulosus | tyrosine protein kinase otk | 0.0014 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0233 | 0.0277 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0014 | 0.0233 | 0.0233 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0209 | 0.8399 | 1 |
Echinococcus multilocularis | lachesin | 0.0014 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0233 | 0.0277 |
Brugia malayi | Prion-like- | 0.0014 | 0.0233 | 0.0196 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0014 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0233 | 0.0277 |
Schistosoma mansoni | tyrosine kinase | 0.0016 | 0.0323 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0233 | 0.0277 |
Entamoeba histolytica | kinesin, putative | 0.0032 | 0.1001 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0233 | 0.0196 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0203 | 0.8146 | 0.8146 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0233 | 0.0277 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0.1001 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0233 | 0.0196 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0233 | 0.0196 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0233 | 0.0196 |
Echinococcus multilocularis | roundabout 2 | 0.0014 | 0.0233 | 0.0233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.122 uM | Inhibition of C-terminal His-tagged microtubule-stimulated KSP motor domain (1 to 369) ATPase activity (unknown origin) preincubated for 30 mins followed by ATP addition measured after 15 mins by luciferase-derived luminescence assay | ChEMBL. | 24184776 |
IC50 (functional) | = 14.8 uM | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 24184776 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24184776 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.