Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | prostaglandin-E synthase | 0.0145 | 0.546 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.546 | 0.546 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.1961 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0131 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1961 | 0.1961 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0145 | 0.546 | 0.5 |
Onchocerca volvulus | 0.0081 | 0.1961 | 0.3435 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0229 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0229 | 1 | 1 |
Onchocerca volvulus | 0.0145 | 0.546 | 1 | |
Trypanosoma brucei | Prostaglandin E synthase | 0.0145 | 0.546 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0131 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 1 | 1 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0145 | 0.546 | 0.5 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.1961 | 0.1961 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.0145 | 0.546 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.1961 | 0.1961 |
Brugia malayi | hypothetical protein | 0.0145 | 0.546 | 0.546 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.1961 | 0.1961 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0131 | 0.0131 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.