Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0131 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1961 | 0.1961 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0145 | 0.546 | 0.5 |
Toxoplasma gondii | prostaglandin-E synthase | 0.0145 | 0.546 | 0.5 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.1961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.546 | 0.546 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0229 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0229 | 1 | 1 |
Onchocerca volvulus | 0.0081 | 0.1961 | 0.3435 | |
Onchocerca volvulus | 0.0145 | 0.546 | 1 | |
Trypanosoma brucei | Prostaglandin E synthase | 0.0145 | 0.546 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0145 | 0.546 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0131 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0131 | 0.0131 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.1961 | 0.1961 |
Brugia malayi | hypothetical protein | 0.0145 | 0.546 | 0.546 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.1961 | 0.1961 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.1961 | 0.1961 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.0145 | 0.546 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.