Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.2256 | 0.3906 | 0.4028 |
Leishmania major | guanosine monophosphate reductase | 0.2256 | 0.3906 | 0.5 |
Echinococcus multilocularis | neurotracting:lsamp:neurotrimin:obcam | 0.0359 | 0.0277 | 0.0286 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.2122 | 0.365 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0359 | 0.0277 | 0.0196 |
Echinococcus granulosus | roundabout 2 | 0.0359 | 0.0277 | 0.0286 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.5284 | 0.9699 | 1 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.5284 | 0.9699 | 1 |
Trypanosoma brucei | GMP reductase | 0.2256 | 0.3906 | 0.5 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.5284 | 0.9699 | 1 |
Trypanosoma cruzi | GMP reductase | 0.2256 | 0.3906 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.2256 | 0.3906 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.5284 | 0.9699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | TK protein kinase | 0.5441 | 1 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0359 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.0277 | 0.0277 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0359 | 0.0277 | 0.0196 |
Brugia malayi | GMP reductase | 0.0937 | 0.1385 | 0.1312 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.2256 | 0.3906 | 0.4028 |
Toxoplasma gondii | IMP dehydrogenas | 0.2256 | 0.3906 | 0.5 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.5284 | 0.9699 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0359 | 0.0277 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.0277 | 0.0277 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.2122 | 0.365 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0359 | 0.0277 | 0.0286 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0257 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.0277 | 0.0277 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.1184 | 0.1857 | 0.0954 |
Echinococcus multilocularis | roundabout 2 | 0.0359 | 0.0277 | 0.0286 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.2256 | 0.3906 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0359 | 0.0277 | 0.0196 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0359 | 0.0277 | 0.0277 |
Echinococcus multilocularis | tyrosine protein kinase otk | 0.0359 | 0.0277 | 0.0286 |
Echinococcus granulosus | peroxidasin | 0.0359 | 0.0277 | 0.0286 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.2256 | 0.3906 | 1 |
Brugia malayi | Peroxidasin | 0.0359 | 0.0277 | 0.0196 |
Echinococcus multilocularis | roundabout 2 | 0.0359 | 0.0277 | 0.0286 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0359 | 0.0277 | 0.0196 |
Echinococcus granulosus | hemicentin 1 | 0.0359 | 0.0277 | 0.0286 |
Echinococcus multilocularis | lachesin | 0.0359 | 0.0277 | 0.0286 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0359 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0359 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.0277 | 0.0277 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.2256 | 0.3906 | 0.3852 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0359 | 0.0277 | 0.0286 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0359 | 0.0277 | 0.0286 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0359 | 0.0277 | 0.0196 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0359 | 0.0277 | 0.0196 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0359 | 0.0277 | 0.0286 |
Echinococcus granulosus | roundabout 2 | 0.0359 | 0.0277 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.0277 | 0.0277 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.2256 | 0.3906 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.0277 | 0.0277 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0937 | 0.1385 | 0.1312 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.2256 | 0.3906 | 0.3906 |
Echinococcus granulosus | tyrosine protein kinase otk | 0.0359 | 0.0277 | 0.0286 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.2122 | 0.365 | 0.8869 |
Echinococcus granulosus | roundabout 2 | 0.0359 | 0.0277 | 0.0286 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0359 | 0.0277 | 0.2004 |
Onchocerca volvulus | Putative GMP reductase | 0.0937 | 0.1385 | 1 |
Echinococcus granulosus | contactin | 0.0359 | 0.0277 | 0.0286 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0359 | 0.0277 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.0277 | 0.0277 |
Echinococcus multilocularis | neuroglian | 0.0359 | 0.0277 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.0277 | 0.0277 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0359 | 0.0277 | 0.0196 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0359 | 0.0277 | 0.0286 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.2256 | 0.3906 | 0.5 |
Loa Loa (eye worm) | GMP reductase | 0.0937 | 0.1385 | 0.1385 |
Brugia malayi | Prion-like- | 0.0359 | 0.0277 | 0.0196 |
Echinococcus granulosus | lachesin | 0.0359 | 0.0277 | 0.0286 |
Schistosoma mansoni | tyrosine kinase | 0.0415 | 0.0385 | 0.0114 |
Echinococcus multilocularis | peroxidasin | 0.0359 | 0.0277 | 0.0286 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.2256 | 0.3906 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0359 | 0.0277 | 0.0196 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0937 | 0.1385 | 0.1312 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.2256 | 0.3906 | 0.3855 |
Trypanosoma cruzi | GMP reductase | 0.2256 | 0.3906 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0359 | 0.0277 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.0277 | 0.0277 |
Echinococcus multilocularis | hemicentin 1 | 0.0359 | 0.0277 | 0.0286 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.2256 | 0.3906 | 0.5 |
Echinococcus multilocularis | hemicentin 1 | 0.0359 | 0.0277 | 0.0286 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.2256 | 0.3906 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.2256 | 0.3906 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.