Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.32 mg kg-1 | Inverse agonist activity of orally administered compound against a subcutaneous dose of 90 mg/kg of PTZ-induced convulsions in mice | ChEMBL. | 2842502 |
ED50 (functional) | = 2.58 mg kg-1 | Inverse agonist activity of orally administered compound against a subcutaneous dose of 75 mg/kg of PTZ-induced convulsions in mice | ChEMBL. | 2842502 |
Ki (binding) | = 0.37 nM | Binding affinity against benzodiazepine (BZ) receptor by displacing [3H]-diazepam in cerebral cortex of Wistar rats | ChEMBL. | 2842502 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.