Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0298 | 0.277 | 0.2522 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0138 | 0.0331 | 0.0331 |
Leishmania major | carbonic anhydrase-like protein | 0.0773 | 1 | 1 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0298 | 0.277 | 0.2522 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.2598 | 0.2598 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0287 | 0.2598 | 0.2344 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0189 | 0.1103 | 0.0799 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0138 | 0.0331 | 0.0331 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0773 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0773 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0773 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0773 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0287 | 0.2598 | 0.2344 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0189 | 0.1103 | 0.1103 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0773 | 1 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0189 | 0.1103 | 0.0799 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0773 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0287 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0331 | 0.0331 |
Echinococcus granulosus | carbonic anhydrase | 0.0287 | 0.2598 | 0.2598 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0287 | 0.2598 | 0.2344 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0189 | 0.1103 | 0.1103 |
Echinococcus multilocularis | carbonic anhydrase | 0.0287 | 0.2598 | 0.2598 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0138 | 0.0331 | 0.0331 |
Echinococcus multilocularis | carbonic anhydrase | 0.0287 | 0.2598 | 0.2598 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0287 | 0.2598 | 0.2344 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0138 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0773 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0773 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0138 | 0.0331 | 0.0331 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0287 | 0.2598 | 0.2344 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0138 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.2598 | 0.2598 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0287 | 0.2598 | 0.2344 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0287 | 0.2598 | 0.2344 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0773 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0138 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0287 | 0.2598 | 0.2598 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0138 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0189 | 0.1103 | 0.1103 |
Schistosoma mansoni | carbonic anhydrase | 0.0287 | 0.2598 | 0.2344 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0138 | 0.0331 | 0.0331 |
Plasmodium falciparum | carbonic anhydrase | 0.0287 | 0.2598 | 0.5 |
Onchocerca volvulus | 0.0298 | 0.277 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0331 | 0.0331 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0138 | 0.0331 | 0.0331 |
Toxoplasma gondii | hypothetical protein | 0.0287 | 0.2598 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0138 | 0.0331 | 0.0331 |
Echinococcus granulosus | carbonic anhydrase | 0.0287 | 0.2598 | 0.2598 |
Schistosoma mansoni | hypothetical protein | 0.0287 | 0.2598 | 0.2344 |
Echinococcus granulosus | carbonic anhydrase | 0.0287 | 0.2598 | 0.2598 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0773 | 1 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0298 | 0.277 | 0.277 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0287 | 0.2598 | 0.2344 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0331 | 0.0331 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of rat liver FBPase | ChEMBL. | No reference | |
IC50 (binding) | = 0.42 uM | Inhibition of human liver FBPase | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.