Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase | 0.006 | 0.0105 | 0.0104 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0258 | 0.0257 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.0105 | 0.0105 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0258 | 0.1925 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0258 | 0.1925 |
Schistosoma mansoni | hexokinase | 0.0096 | 0.0258 | 1 |
Toxoplasma gondii | prostaglandin-E synthase | 0.238 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0127 | 0.0127 |
Onchocerca volvulus | 0.0096 | 0.0258 | 0.0155 | |
Onchocerca volvulus | 0.0096 | 0.0258 | 0.0155 | |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.0258 | 0.0257 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.0258 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.0258 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.0258 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 0.0258 | 0.1925 |
Brugia malayi | hexokinase | 0.0096 | 0.0258 | 0.0258 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.0258 | 0.5 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.238 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.0258 | 0.5 |
Echinococcus multilocularis | Ankyrin | 0.0036 | 0.0001 | 0.0004 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0258 | 0.1925 |
Onchocerca volvulus | 0.238 | 1 | 1 | |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0036 | 0.0001 | 0.0023 |
Onchocerca volvulus | 0.0096 | 0.0258 | 0.0155 | |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0258 | 0.0257 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.0258 | 0.0258 |
Echinococcus granulosus | Ankyrin | 0.0036 | 0.0001 | 0.0004 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.238 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0258 | 0.1925 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0258 | 0.1925 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 0.0258 | 0.1925 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0258 | 0.1925 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.035 | 0.1339 | 1 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.238 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.238 | 1 | 1 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.035 | 0.1339 | 1 |
Trypanosoma brucei | Prostaglandin E synthase | 0.238 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 12.9 ml/min.kg | Intrinsic clearance in human liver microsomes | ChEMBL. | No reference |
EC50 (binding) | = 2170 nM | Activation of recombinant human glucokinase assessed as formation of glucose-6-phosphate by G6PDH/NADP coupled assay | LITERATURE. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.