TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 679.684 | Formula: C32H40F3N5O8
H donors: 6 H acceptors: 7 LogP: 3.81 Rotable bonds: 22
Rule of 5 violations (Lipinski): 3
SMILES: COC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)Cc1ccc(cc1)NC(=O)Nc1ccccc1C(F)(F)F)CC(C)C)CC(=O)O
InChi: 1S/C32H40F3N5O8/c1-17(2)14-23(28(44)38-24(16-26(42)43)29(45)40-27(18(3)4)30(46)48-5)37-25(41)15-19-10-12-20(13-11-19)36-31(47)39-22-9-7-6-8-21(22)32(33,34)35/h6-13,17-18,23-24,27H,14-16H2,1-5H3,(H,37,41)(H,38,44)(H,40,45)(H,42,43)(H2,36,39,47)/t23-,24-,27-/m0/s1
InChiKey: XJSRCFMOUMHDOC-DPZBCOQUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Schistosoma mansoni	tyrosine protein kinase	0.0189	0.3404	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.0531	0.0531
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0189	0.3404	0.6947
Echinococcus granulosus	tyrosine protein kinase HCK	0.0189	0.3404	0.3404
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0189	0.3404	0.3404
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0189	0.3404	1
Brugia malayi	Guanylyl cyclase protein 23	0.0189	0.3404	0.6927
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Brugia malayi	SRC-1	0.0189	0.3404	0.6927
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0189	0.3404	0.3404
Schistosoma mansoni	protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0531	0.1085
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.1058	0.2418
Echinococcus granulosus	tyrosine protein kinase csk	0.0189	0.3404	0.3404
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0042	0.0531	0.0531
Echinococcus granulosus	tyrosine protein kinase Blk	0.0189	0.3404	0.3404
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0189	0.3404	0.6947
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0189	0.3404	0.3404
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0189	0.3404	0.6927
Trypanosoma cruzi	protein kinase, putative	0.0189	0.3404	1
Schistosoma mansoni	protein tyrosine kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK protein kinase	0.0189	0.3404	0.6947
Entamoeba histolytica	hypothetical protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Echinococcus multilocularis	c src tyrosine kinase	0.0189	0.3404	0.3404
Echinococcus granulosus	ephrin type A receptor 4 A	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Echinococcus multilocularis	ubiquitin specific protease 41	0.0042	0.0531	0.0531
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Schistosoma mansoni	ephrin receptor	0.0189	0.3404	1
Plasmodium falciparum	protein kinase, putative	0.0189	0.3404	0.5
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Schistosoma mansoni	serine/threonine protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	SRC-1	0.0189	0.3404	0.6947
Echinococcus multilocularis	protein tyrosine kinase	0.0189	0.3404	0.3404
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Plasmodium falciparum	tyrosine kinase-like protein	0.0189	0.3404	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0528	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Entamoeba histolytica	ankyrin repeat protein	0.0189	0.3404	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0189	0.3404	0.3404
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0189	0.3404	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0189	0.3404	0.6947
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Echinococcus granulosus	tyrosine kinase	0.0189	0.3404	0.3404
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Brugia malayi	intermediate filament protein	0.0031	0.0309	0.057
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus granulosus	tyrosine kinase	0.0189	0.3404	0.3404
Onchocerca volvulus		0.0189	0.3404	1
Schistosoma mansoni	serine/threonine protein kinase	0.0189	0.3404	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0189	0.3404	0.3404
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0189	0.3404	0.6927
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Onchocerca volvulus		0.0189	0.3404	1
Schistosoma mansoni	protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0189	0.3404	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Giardia lamblia	Kinase, NEK	0.0189	0.3404	1
Echinococcus multilocularis	lamin dm0	0.0031	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0189	0.3404	0.6947
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0189	0.3404	0.3404
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK protein kinase	0.0189	0.3404	0.6947
Loa Loa (eye worm)	TK/EPH protein kinase	0.0189	0.3404	0.6947
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.1058	0.2418
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0189	0.3404	0.3404
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0309	0.0631
Echinococcus multilocularis	neuropeptide receptor A26	0.0528	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.3404	1
Onchocerca volvulus		0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0189	0.3404	0.6947
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Echinococcus granulosus	ubiquitin specific protease 41	0.0042	0.0531	0.0531
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0189	0.3404	0.6947
Entamoeba histolytica	tyrosin kinase, putative	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Brugia malayi	Raf kinase	0.0189	0.3404	0.6927
Echinococcus multilocularis	epidermal growth factor receptor	0.0189	0.3404	0.3404
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0189	0.3404	1
Loa Loa (eye worm)	TK protein kinase	0.0189	0.3404	0.6947
Schistosoma mansoni	protein kinase	0.0189	0.3404	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Echinococcus multilocularis	transfer RNA-Thr	0.0189	0.3404	0.3404
Echinococcus granulosus	integrin linked protein kinase	0.0189	0.3404	0.3404
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0309	0.0631
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0189	0.3404	0.3404
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0189	0.3404	0.3404
Schistosoma mansoni	hypothetical protein	0.0189	0.3404	1
Brugia malayi	integrin-linked kinase	0.0189	0.3404	0.6927
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0189	0.3404	0.3404
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0189	0.3404	0.3404
Trypanosoma cruzi	protein kinase, putative	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Trypanosoma brucei	protein kinase, putative	0.0189	0.3404	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0189	0.3404	0.3404
Brugia malayi	hypothetical protein	0.0189	0.3404	0.6927
Loa Loa (eye worm)	TK protein kinase	0.0189	0.3404	0.6947
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.3404	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0189	0.3404	0.3404
Echinococcus granulosus	tyrosine kinase	0.0189	0.3404	0.3404
Entamoeba histolytica	receptor protein kinase, putative	0.0189	0.3404	1
Brugia malayi	follicle stimulating hormone receptor	0.0266	0.49	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0189	0.3404	0.3404
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0069	0.1058	0.1058
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0189	0.3404	0.3404
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0189	0.3404	0.3404
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0189	0.3404	1
Echinococcus granulosus	protein tyrosine kinase	0.0189	0.3404	0.3404
Onchocerca volvulus		0.0189	0.3404	1
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0042	0.0531	0.0531
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0189	0.3404	0.3404
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Onchocerca volvulus		0.0189	0.3404	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	hypothetical protein	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0189	0.3404	0.3404
Entamoeba histolytica	tyrosin kinase, putative	0.0189	0.3404	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0189	0.3404	0.6947
Echinococcus multilocularis	activated cdc42 kinase 1	0.0189	0.3404	0.3404
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Entamoeba histolytica	hypothetical protein, conserved	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0189	0.3404	0.6947
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Echinococcus multilocularis	FL cytokine receptor	0.0189	0.3404	0.3404
Plasmodium falciparum	tyrosine kinase-like protein	0.0189	0.3404	0.5
Schistosoma mansoni	protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	CAMK family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	tyrosin kinase, putative	0.0189	0.3404	1
Echinococcus multilocularis	protein kinase	0.0189	0.3404	0.3404
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0189	0.3404	0.3404
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0189	0.3404	0.3404
Toxoplasma gondii	STE kinase	0.0189	0.3404	1
Echinococcus multilocularis	protein kinase	0.0189	0.3404	0.3404
Loa Loa (eye worm)	hypothetical protein	0.003	0.0298	0.0609
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0189	0.3404	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Trypanosoma brucei	Pseudokinase, putative	0.0189	0.3404	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Echinococcus granulosus	lamin dm0	0.0031	0.0309	0.0309
Echinococcus granulosus	c src tyrosine kinase	0.0189	0.3404	0.3404
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0189	0.3404	0.3404
Echinococcus multilocularis	insulin receptor	0.0189	0.3404	0.3404
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0189	0.3404	0.3404
Loa Loa (eye worm)	TK/ALK protein kinase	0.0189	0.3404	0.6947
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0189	0.3404	1
Loa Loa (eye worm)	TK protein kinase	0.0189	0.3404	0.6947
Echinococcus multilocularis	tyrosine protein kinase csk	0.0189	0.3404	0.3404
Leishmania major	protein kinase, putative	0.0189	0.3404	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0189	0.3404	0.3404
Onchocerca volvulus		0.0189	0.3404	1
Echinococcus granulosus	protein kinase	0.0189	0.3404	0.3404
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus multilocularis	integrin linked protein kinase	0.0189	0.3404	0.3404
Echinococcus granulosus	activated cdc42 kinase 1	0.0189	0.3404	0.3404
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0189	0.3404	0.3404
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0189	0.3404	0.6927
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Trichomonas vaginalis	AGC family protein kinase	0.0189	0.3404	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0189	0.3404	0.3404
Brugia malayi	protein-tyrosine kinase	0.0189	0.3404	0.6927
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0189	0.3404	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0189	0.3404	1
Entamoeba histolytica	ankyrin repeat protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0189	0.3404	0.6927
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0189	0.3404	0.3404
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0189	0.3404	0.3404
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0189	0.3404	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Echinococcus granulosus	lamin	0.0031	0.0309	0.0309
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0189	0.3404	0.6947
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0266	0.49	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0189	0.3404	0.3404
Entamoeba histolytica	hypothetical protein	0.0189	0.3404	1
Trichomonas vaginalis	STE family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.3404	1
Schistosoma mansoni	serine/threonine protein kinase	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0189	0.3404	0.3404
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0189	0.3404	0.3404
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0189	0.3404	0.3404
Entamoeba histolytica	receptor protein kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	hypothetical protein	0.0189	0.3404	1
Brugia malayi	hypothetical protein	0.0189	0.3404	0.6927
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0189	0.3404	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0189	0.3404	0.6927
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0042	0.0531	0.1026
Echinococcus granulosus	insulin receptor	0.0189	0.3404	0.3404
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	tyrosin kinase, putative	0.0189	0.3404	1
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0042	0.0531	0.0717
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Echinococcus granulosus	tyrosine protein kinase	0.0189	0.3404	0.3404
Brugia malayi	Receptor family ligand binding region containing protein	0.0189	0.3404	0.6927
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0189	0.3404	0.6947
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0189	0.3404	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Toxoplasma gondii	protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK protein kinase	0.0189	0.3404	0.6947
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0189	0.3404	0.6947
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Echinococcus multilocularis	neuropeptide s receptor	0.0528	1	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0189	0.3404	0.3404
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0189	0.3404	1
Onchocerca volvulus		0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0189	0.3404	0.3404
Plasmodium vivax	protein kinase, putative	0.0189	0.3404	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0189	0.3404	0.3404
Giardia lamblia	Kinase	0.0189	0.3404	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0189	0.3404	0.3404
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0189	0.3404	0.3404
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0189	0.3404	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0189	0.3404	1
Schistosoma mansoni	serine/threonine RGC	0.0189	0.3404	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0189	0.3404	0.3404
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0189	0.3404	0.3404
Onchocerca volvulus		0.0189	0.3404	1
Echinococcus granulosus	epidermal growth factor receptor	0.0189	0.3404	0.3404
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0069	0.1058	0.1833
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0189	0.3404	0.6947
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Trichomonas vaginalis	TK family protein kinase	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Schistosoma mansoni	protein kinase	0.0189	0.3404	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0069	0.1058	0.1058
Schistosoma mansoni	protein kinase	0.0189	0.3404	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0189	0.3404	0.3404
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0189	0.3404	0.3404
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0189	0.3404	0.3404
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Onchocerca volvulus		0.0189	0.3404	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.1058	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0189	0.3404	0.6927
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0189	0.3404	0.6927
Onchocerca volvulus		0.0189	0.3404	1
Onchocerca volvulus		0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0189	0.3404	0.3404
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.3404	1
Entamoeba histolytica	hypothetical protein	0.0189	0.3404	1
Leishmania major	hypothetical protein, conserved	0.0189	0.3404	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0189	0.3404	1
Brugia malayi	ephrin receptor 1 precursor	0.0189	0.3404	0.6927
Echinococcus granulosus	receptor type guanylyl cyclase	0.0189	0.3404	0.3404
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.1058	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0189	0.3404	0.3404
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	hypothetical protein	0.0189	0.3404	1
Entamoeba histolytica	hypothetical protein	0.0189	0.3404	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine kinase	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Loa Loa (eye worm)	TK protein kinase	0.0189	0.3404	0.6947
Schistosoma mansoni	protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Loa Loa (eye worm)	TK/Met protein kinase	0.0189	0.3404	0.6947
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0189	0.3404	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0189	0.3404	0.3404
Onchocerca volvulus		0.0189	0.3404	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0189	0.3404	0.3404
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0189	0.3404	0.3404
Entamoeba histolytica	cysteine surface protein, putative	0.0189	0.3404	1
Brugia malayi	hypothetical protein	0.0189	0.3404	0.6927
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0189	0.3404	0.3404
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Schistosoma mansoni	protein kinase	0.0189	0.3404	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.1058	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Echinococcus granulosus	epidermal growth factor receptor	0.0189	0.3404	0.3404
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0189	0.3404	0.6947
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0189	0.3404	0.6947
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0189	0.3404	0.3404
Brugia malayi	Tyrosine-protein kinase abl-1	0.0189	0.3404	0.6927
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Giardia lamblia	Kinase, NEK	0.0189	0.3404	1
Schistosoma mansoni	protein kinase	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.0531	0.0531
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0189	0.3404	0.3404
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0189	0.3404	0.3404
Giardia lamblia	Protein 21.1	0.0189	0.3404	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.3404	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0189	0.3404	0.3404
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0189	0.3404	0.3404
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0189	0.3404	0.3404
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine kinase	0.0189	0.3404	0.3404
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Brugia malayi	SH2 domain containing protein	0.0189	0.3404	0.6927
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Entamoeba histolytica	hypothetical protein	0.0189	0.3404	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0042	0.0531	0.0717
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0189	0.3404	0.3404
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0189	0.3404	0.3404
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0189	0.3404	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0189	0.3404	0.3404
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0189	0.3404	0.3404
Onchocerca volvulus		0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Onchocerca volvulus		0.0189	0.3404	1
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0309	0.0631
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0189	0.3404	1
Entamoeba histolytica	hypothetical protein	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase	0.0189	0.3404	0.3404
Loa Loa (eye worm)	TK/INSR protein kinase	0.0189	0.3404	0.6947
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0189	0.3404	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0189	0.3404	0.3404
Plasmodium falciparum	protein kinase, putative	0.0189	0.3404	0.5
Brugia malayi	SH2 domain containing protein	0.0189	0.3404	0.6927
Loa Loa (eye worm)	serine/threonine protein kinase	0.0189	0.3404	0.6947
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.3404	1
Echinococcus multilocularis	heat shock protein 70	0.0189	0.3404	0.3404
Loa Loa (eye worm)	TK/ACK protein kinase	0.0189	0.3404	0.6947
Echinococcus multilocularis	activin receptor type	0.0189	0.3404	0.3404
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0189	0.3404	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Onchocerca volvulus		0.0189	0.3404	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Brugia malayi	C-terminal src kinase protein 1	0.0189	0.3404	0.6927
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Loa Loa (eye worm)	TK protein kinase	0.0189	0.3404	0.6947
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0189	0.3404	0.6927
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	hypothetical protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0032	0.0065
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0189	0.3404	0.6927
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0189	0.3404	0.6927
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0189	0.3404	0.6947
Schistosoma mansoni	protein kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK protein kinase	0.0189	0.3404	0.6947
Echinococcus granulosus	intermediate filament protein	0.0031	0.0309	0.0309
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0189	0.3404	0.6947
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0189	0.3404	0.3404
Schistosoma mansoni	ephrin receptor	0.0189	0.3404	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.3404	0.6947
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0189	0.3404	0.3404
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.3404	1
Entamoeba histolytica	hypothetical protein	0.0189	0.3404	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0189	0.3404	0.6927
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0189	0.3404	0.6947
Loa Loa (eye worm)	TK/ABL protein kinase	0.0189	0.3404	0.6947
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0189	0.3404	0.3404
Echinococcus granulosus	tyrosine protein kinase csk	0.0189	0.3404	0.3404
Entamoeba histolytica	protein kinase, putative	0.0189	0.3404	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Echinococcus granulosus	tyrosine protein kinase pr2	0.0189	0.3404	0.3404
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0189	0.3404	0.3404
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0189	0.3404	0.6947
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0189	0.3404	0.6947
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.3404	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0309	0.057
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.3404	0.6947
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.3404	1
Echinococcus multilocularis	lamin	0.0031	0.0309	0.0309
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0189	0.3404	0.3404
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0189	0.3404	0.3404
Onchocerca volvulus	Tyrosine kinase homolog	0.0189	0.3404	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0189	0.3404	0.3404
Schistosoma mansoni	protein kinase	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0189	0.3404	0.5
Plasmodium falciparum	protein kinase, putative	0.0189	0.3404	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0189	0.3404	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0069	0.1058	0.5
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0189	0.3404	0.3404
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0189	0.3404	0.3404
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.3404	1
Schistosoma mansoni	serine/threonine protein kinase	0.0189	0.3404	1
Leishmania major	protein kinase, putative	0.0189	0.3404	1
Loa Loa (eye worm)	TK protein kinase	0.0189	0.3404	0.6947
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Brugia malayi	Protein kinase domain containing protein	0.0189	0.3404	0.6927
Echinococcus granulosus	activin receptor type	0.0189	0.3404	0.3404
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0189	0.3404	1
Echinococcus multilocularis	musashi	0.0031	0.0309	0.0309
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.3404	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0189	0.3404	0.3404
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0189	0.3404	0.3404

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 703 uM	Antagonist activity at integrin alpha4beta1 receptor in human CCRF-CEM cells assessed as inhibition of cell adhesion to fibronectin after 1 hr by calcein AM staining-based fluorescence assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3220764

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1853987