Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.7442 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2906 | 0.3428 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.7442 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.7442 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2906 | 0.3428 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.2906 | 0.3428 | 0.3428 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.7442 | 1 | 0.5 |
Onchocerca volvulus | Deterin homolog | 0.054 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2906 | 0.3428 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.7442 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.7442 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.7442 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.7442 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.7442 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2906 | 0.3428 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.2906 | 0.3428 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.7442 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.7442 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2906 | 0.3428 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.7442 | 1 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.2906 | 0.3428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.7442 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2906 | 0.3428 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2906 | 0.3428 | 0.5 |
Onchocerca volvulus | 0.054 | 0 | 0.5 | |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2906 | 0.3428 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2906 | 0.3428 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.7442 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.15 uM | Binding affinity against Angiotensin II receptor, from rat adrenal gland | ChEMBL. | 1956044 |
IC50 (binding) | = 0.15 uM | Binding affinity against Angiotensin II receptor, from rat adrenal gland | ChEMBL. | 1956044 |
IC50 (binding) | = 1.6 uM | Binding affinity for rat brain Angiotensin II receptor | ChEMBL. | 1956044 |
IC50 (binding) | = 1.6 uM | Binding affinity for rat brain Angiotensin II receptor | ChEMBL. | 1956044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.