Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.079 | 0.4499 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.079 | 0.4499 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.079 | 0.4499 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0351 | 0.0874 | 0.0394 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.079 | 0.4499 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.079 | 0.4499 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.079 | 0.4499 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0351 | 0.0874 | 0.0394 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.079 | 0.4499 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.079 | 0.4499 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.079 | 0.4499 | 0.4499 |
Brugia malayi | eukaryotic initiation factor 4A | 0.079 | 0.4499 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.079 | 0.4499 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0351 | 0.0874 | 0.0874 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.079 | 0.4499 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.079 | 0.4499 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.079 | 0.4499 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.079 | 0.4499 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.079 | 0.4499 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.079 | 0.4499 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.079 | 0.4499 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.079 | 0.4499 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.079 | 0.4499 | 0.5 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0333 | 0.0726 | 0.0726 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.079 | 0.4499 | 0.4499 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.079 | 0.4499 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.079 | 0.4499 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.079 | 0.4499 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 78 nM | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | ChEMBL. | 12039560 |
Ki (binding) | = 300 nM | Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes | ChEMBL. | 12039560 |
Ki (binding) | = 885 nM | Inhibitory activity against human recombinant carbonic anhydrase I (CA1) | ChEMBL. | 12039560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.