Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0116 | 0.2263 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0116 | 0.2263 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0125 | 0.2502 | 0.0309 |
Toxoplasma gondii | ribonuclease HI protein | 0.0116 | 0.2263 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0116 | 0.2263 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0125 | 0.2502 | 0.0309 |
Giardia lamblia | Ribonuclease H | 0.0116 | 0.2263 | 0.5 |
Brugia malayi | RNase H family protein | 0.0116 | 0.2263 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0125 | 0.2502 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | ACC-1 protein | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | ribonuclease H1 | 0.0116 | 0.2263 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0125 | 0.2502 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0116 | 0.2263 | 0.5 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Brugia malayi | RNase H family protein | 0.0116 | 0.2263 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0116 | 0.2263 | 0.2263 |
Schistosoma mansoni | phosphoglucomutase | 0.0116 | 0.2263 | 0.2263 |
Loa Loa (eye worm) | ACC-1 protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Brugia malayi | RNase H family protein | 0.0116 | 0.2263 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0116 | 0.2263 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0116 | 0.2263 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0433 | 1 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0125 | 0.2502 | 0.0309 |
Loa Loa (eye worm) | LGC-31 protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0116 | 0.2263 | 0.2263 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | ribonuclease H1 | 0.0116 | 0.2263 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Leishmania major | ribonuclease H1, putative | 0.0116 | 0.2263 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Hill coefficient (functional) | = 1 | Hill value, slope calculated from GABA-current potentiation in Xenopus oocytes | ChEMBL. | 9016329 |
IC50 (binding) | = 614 nM | Ability to allosterically modulate the binding of [35S]-TBPS to gamma-aminobutyric-acid A receptor in rat brain cortical P2 membranes. | ChEMBL. | 9016329 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.