Detailed information for compound 1870124

Basic information

Technical information
  • TDR Targets ID: 1870124
  • Name: 2-[(2-methylpropan-2-yl)oxycarbonyl]benzoic a cid
  • MW: 222.237 | Formula: C12H14O4
  • H donors: 1 H acceptors: 3 LogP: 2.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1C(=O)O)OC(C)(C)C
  • InChi: 1S/C12H14O4/c1-12(2,3)16-11(15)9-7-5-4-6-8(9)10(13)14/h4-7H,1-3H3,(H,13,14)
  • InChiKey: PBUQZKXKYSAJDO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-tert-butoxycarbonylbenzoic acid
  • 2-(tert-butoxy-oxomethyl)benzoic acid
  • 33693-84-4
  • 1,2-Benzenedicarboxylic acid, mono(1,1-dimethylethyl) ester
  • t-Monobutyl phthalate
  • SBB007635
  • t-Butyl hydrogen phthalate
  • tert-Butyl hydrogen phthalate
  • FR-0008

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni metabotropic glutamate receptor 0.0026 0.0332 0.0431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0896 0.1341
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0087 0.3234 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0896 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0896 0.1341
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0047 0.1311 0.1961
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.1458 0.1892
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Onchocerca volvulus 0.0047 0.1311 0.1401
Echinococcus granulosus nmda type glutamate receptor 0.0091 0.342 0.4437
Schistosoma mansoni glutamate receptor AMPA 0.0039 0.0927 0.1203
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Echinococcus granulosus nAChR subunit 0.0087 0.3238 0.4202
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.004 0.0987 0.1281
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.004 0.0987 0.1477
Echinococcus granulosus glutamate receptor 2 0.005 0.1458 0.1892
Schistosoma mansoni nAChR subunit 0.0087 0.3238 0.4202
Brugia malayi Cation transporter family protein 0.0087 0.3238 0.4846
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0087 0.3238 0.4202
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0896 0.1163
Loa Loa (eye worm) hypothetical protein 0.0158 0.6683 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0436 0.0652
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0896 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.3238 0.4202
Echinococcus multilocularis musashi 0.0029 0.0436 0.0565
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0254 0.0254
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0056 0.1733 0.2248
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.3238 0.4202
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0087 0.3238 0.4202
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0087 0.3238 0.4846
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.0047 0.1311 0.1961
Trypanosoma cruzi Peptide deformylase 2, putative 0.0087 0.3234 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Loa Loa (eye worm) acetylcholine receptor protein 0.004 0.0987 0.1477
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1227 0.1836
Brugia malayi hypothetical protein 0.0127 0.5187 0.7762
Echinococcus multilocularis glutamate receptor NMDA 0.0076 0.2729 0.354
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.3238 0.4202
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0158 0.6683 0.867
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0087 0.3234 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.004 0.0987 0.1477
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0087 0.3238 0.4846
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0087 0.3238 0.4202
Loa Loa (eye worm) hypothetical protein 0.0047 0.1311 0.1961
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0896 0.1163
Schistosoma mansoni acetylcholine receptor-related 0.004 0.0987 0.1281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1227 0.1592
Brugia malayi Cation transporter family protein 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Echinococcus multilocularis nAChR subunit 0.0047 0.1311 0.1701
Loa Loa (eye worm) hypothetical protein 0.0056 0.1733 0.2593
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1227 0.1836
Entamoeba histolytica hypothetical protein 0.0047 0.1311 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0299 0.0447
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0896 0.1163
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0436 0.0652
Echinococcus multilocularis metabotropic glutamate receptor 2 0.004 0.0992 0.1287
Loa Loa (eye worm) LGC-31 protein 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.004 0.0987 0.1477
Onchocerca volvulus 0.004 0.0987 0.0883
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0087 0.3238 0.4846
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.1458 0.1892
Brugia malayi Cytochrome P450 family protein 0.0026 0.0299 0.0447
Echinococcus granulosus glutamate receptor 2 0.0035 0.0767 0.0995
Loa Loa (eye worm) GABA receptor subunit 0.0047 0.1311 0.1961
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.1311 0.1701
Schistosoma mansoni nAChR subunit 0.0087 0.3238 0.4202
Echinococcus granulosus metabotropic glutamate receptor 5 0.0056 0.1733 0.2248
Trypanosoma brucei Peptide deformylase 2 0.0087 0.3234 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.1311 0.1961
Brugia malayi hypothetical protein 0.004 0.0987 0.1477
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0087 0.3238 0.4202
Schistosoma mansoni hypothetical protein 0.018 0.7708 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0254 0.0254
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0254 0.0785
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0896 0.2772
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0047 0.1311 0.1961
Schistosoma mansoni nAChR subunit 0.004 0.0987 0.1281
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0896 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.3238 0.4202
Brugia malayi hypothetical protein 0.004 0.0987 0.1477
Brugia malayi hypothetical protein 0.0025 0.0254 0.038
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0087 0.3238 0.4846
Echinococcus granulosus nAChR subunit 0.0047 0.1311 0.1701
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0896 1
Toxoplasma gondii hypothetical protein 0.0227 1 1
Onchocerca volvulus 0.0087 0.3238 0.4487
Echinococcus multilocularis lamin 0.0029 0.0436 0.0565
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Onchocerca volvulus 0.004 0.0987 0.0883
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0896 0.2772
Echinococcus granulosus glycine receptor subunit beta 0.0087 0.3238 0.4202
Echinococcus granulosus lamin 0.0029 0.0436 0.0565
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Loa Loa (eye worm) hypothetical protein 0.0047 0.1311 0.1961
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1227 0.1592
Brugia malayi excitatory GABA receptor EXP-1A 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Onchocerca volvulus 0.0087 0.3238 0.4487
Brugia malayi hypothetical protein 0.004 0.0987 0.1477
Onchocerca volvulus 0.004 0.0987 0.0883
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.1458 0.1892
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0087 0.3238 0.4202
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Mycobacterium ulcerans peptide deformylase 0.0227 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0436 0.0652
Schistosoma mansoni glutamate receptor AMPA 0.0039 0.0927 0.1203
Echinococcus granulosus glycine receptor subunit beta 0.0087 0.3238 0.4202
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.3238 0.4846
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0227 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.1311 0.1961
Echinococcus multilocularis glycine receptor subunit beta 0.0087 0.3238 0.4202
Loa Loa (eye worm) hypothetical protein 0.0047 0.1311 0.1961
Schistosoma mansoni glutamate receptor kainate 0.0039 0.0927 0.1203
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.3238 0.4202
Schistosoma mansoni nAChR subunit 0.0087 0.3238 0.4202
Echinococcus granulosus intermediate filament protein 0.0029 0.0436 0.0565
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0087 0.3238 0.4202
Schistosoma mansoni lamin 0.0029 0.0436 0.0565
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0436 0.0652
Loa Loa (eye worm) glutamate receptor 0.0046 0.1298 0.1942
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1227 0.1592
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0987 0.1281
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.1458 0.1892
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1227 0.1592
Brugia malayi Cation transporter family protein 0.0087 0.3238 0.4846
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.0047 0.1311 0.1961
Trypanosoma brucei Polypeptide deformylase 1 0.0087 0.3234 1
Onchocerca volvulus 0.0087 0.3238 0.4487
Leishmania major polypeptide deformylase-like protein, putative 0.0087 0.3234 1
Schistosoma mansoni hypothetical protein 0.018 0.7708 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0987 0.1477
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1227 0.1592
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Schistosoma mansoni nAChR subunit 0.0087 0.3238 0.4202
Echinococcus granulosus metabotropic glutamate receptor 2 0.004 0.0992 0.1287
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.3238 0.4846
Schistosoma mansoni acetylcholine receptor subunit beta 0.004 0.0987 0.1281
Schistosoma mansoni nAChR subunit 0.004 0.0987 0.1281
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0087 0.3238 0.4202
Schistosoma mansoni metabotropic glutamate receptor 0.004 0.0992 0.1287
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.1458 0.1892
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0896 0.2772
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.1458 0.1892
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0158 0.6683 0.867
Echinococcus granulosus lamin dm0 0.0029 0.0436 0.0565
Schistosoma mansoni lamin 0.0029 0.0436 0.0565
Echinococcus granulosus glutamate NMDA receptor subunit 0.0092 0.3496 0.4535
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.3238 0.4846
Onchocerca volvulus 0.0087 0.3238 0.4487
Loa Loa (eye worm) hypothetical protein 0.0127 0.5187 0.7762
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.3238 0.4846
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.004 0.0987 0.1281
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0158 0.6683 0.867
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.004 0.0987 0.1281
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.3238 0.4202
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.004 0.0987 0.1281
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0047 0.1311 0.1701
Brugia malayi Glutamate receptor 2 precursor 0.0039 0.0927 0.1387
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0087 0.3238 0.4202
Echinococcus multilocularis glutamate receptor 2 0.0039 0.0927 0.1203
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0044 0.1202 0.1559
Echinococcus multilocularis nmda type glutamate receptor 0.0087 0.326 0.423
Schistosoma mansoni glutamate receptor kainate 0.0039 0.0927 0.1203
Brugia malayi Metabotropic glutamate receptor precursor. 0.0046 0.1298 0.1942
Brugia malayi hypothetical protein 0.004 0.0987 0.1477
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0254 0.0254
Onchocerca volvulus Huntingtin homolog 0.0127 0.5187 0.7606
Loa Loa (eye worm) ACC-1 protein 0.0087 0.3238 0.4846
Loa Loa (eye worm) glutamate receptor 2 0.0039 0.0927 0.1387
Loa Loa (eye worm) glutamate receptor 1 0.0039 0.0927 0.1387
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0896 0.1163
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0087 0.3238 0.4846
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.3238 0.4846
Brugia malayi metabotropic glutamate receptor type 2 0.0026 0.0332 0.0497
Onchocerca volvulus Putative nachr subunit 0.0158 0.6683 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0087 0.3234 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.004 0.0987 0.1477
Echinococcus multilocularis nAChR subunit 0.0087 0.3238 0.4202
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Echinococcus multilocularis glutamate receptor 2 0.005 0.1458 0.1892
Leishmania major hypothetical protein, conserved 0.0025 0.0254 0.0785
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Echinococcus granulosus geminin 0.018 0.7708 1
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0896 0.1163
Loa Loa (eye worm) hypothetical protein 0.0025 0.0254 0.038
Treponema pallidum polypeptide deformylase (def) 0.0227 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0158 0.6683 0.867
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.3238 0.4202
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0087 0.3238 0.4846
Brugia malayi Glutamate receptor 1 precursor 0.0039 0.0927 0.1387
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0254 0.0785
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0047 0.1311 0.1961
Loa Loa (eye worm) hypothetical protein 0.0028 0.0411 0.0614
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.0127 0.5187 0.7762
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.3238 0.4202
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0087 0.3238 0.4202
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0158 0.6683 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1227 0.1592
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.3238 0.4202
Schistosoma mansoni glutamate receptor NMDA 0.0126 0.5128 0.6653
Echinococcus multilocularis geminin 0.018 0.7708 1
Schistosoma mansoni glutamate receptor kainate 0.0039 0.0927 0.1203
Plasmodium falciparum peptide deformylase 0.0227 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.1458 0.1892
Brugia malayi hypothetical protein 0.004 0.0987 0.1477
Schistosoma mansoni ATP-binding cassette transporter 0.0039 0.0927 0.1203
Brugia malayi intermediate filament protein 0.0029 0.0436 0.0652
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Onchocerca volvulus 0.0087 0.3238 0.4487
Schistosoma mansoni nAChR subunit 0.0087 0.3238 0.4202
Echinococcus granulosus nmda type glutamate receptor 0.0087 0.326 0.423
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.004 0.0987 0.1281
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0087 0.3238 0.4202
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0087 0.3238 0.4202
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0047 0.1311 0.1701
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0987 0.1477
Onchocerca volvulus Huntingtin homolog 0.0127 0.5187 0.7606
Echinococcus multilocularis lamin dm0 0.0029 0.0436 0.0565
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0035 0.0766 0.1147
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.3238 0.4846
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.004 0.0987 0.1477
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0092 0.3496 0.4535
Schistosoma mansoni nAChR subunit 0.0087 0.3238 0.4202
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0896 0.1163
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Schistosoma mansoni intermediate filament proteins 0.0029 0.0436 0.0565
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0254 0.0785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1227 0.1592
Loa Loa (eye worm) hypothetical protein 0.0047 0.1311 0.1961
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0227 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Onchocerca volvulus 0.0087 0.3238 0.4487
Echinococcus multilocularis glycine receptor subunit beta 0.0087 0.3238 0.4202
Echinococcus multilocularis glutamate receptor 2 0.0035 0.0767 0.0995
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0227 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.1458 0.1892
Schistosoma mansoni nAChR subunit 0.0087 0.3238 0.4202
Echinococcus granulosus glutamate receptor NMDA 0.0076 0.2729 0.354
Loa Loa (eye worm) hypothetical protein 0.004 0.0987 0.1477
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0158 0.6683 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0896 0.1163
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0087 0.3238 0.4846
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0047 0.1311 0.1961
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0087 0.3238 0.4202
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0896 0.2772
Loa Loa (eye worm) hypothetical protein 0.0087 0.3238 0.4846
Onchocerca volvulus 0.0047 0.1311 0.1401
Schistosoma mansoni glutamate receptor NMDA 0.0092 0.3496 0.4535
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0087 0.3238 0.4846
Loa Loa (eye worm) ACC-1 protein 0.0087 0.3238 0.4846
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0158 0.6683 0.867
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0896 0.1163
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0158 0.6683 0.867
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0896 0.6839
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0987 0.1477
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0254 0.0254
Echinococcus multilocularis nmda type glutamate receptor 0.0091 0.342 0.4437
Loa Loa (eye worm) hypothetical protein 0.0047 0.1311 0.1961
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0987 0.1281
Plasmodium vivax peptide deformylase, putative 0.0227 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 61.6448 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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