Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0121 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2692 | 0.5349 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0056 | 0.0469 | 0.0351 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Echinococcus multilocularis | calpain A | 0.0055 | 0.0452 | 0.0335 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0056 | 0.0469 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0312 | 0.0391 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.0452 | 0.0314 |
Leishmania major | fk506-binding protein 1-like protein | 0.0056 | 0.0469 | 0.5 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0056 | 0.0469 | 0.5 |
Echinococcus granulosus | peptidase s8 s53 subtilisin kexin sedolisin | 0.01 | 0.1365 | 0.1087 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0056 | 0.0469 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.0056 | 0.0469 | 0.0352 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0053 | 0.0404 | 0.0505 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0056 | 0.0469 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0053 | 0.0404 | 0.0205 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0056 | 0.0469 | 0.0352 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2692 | 0.5349 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0039 | 0.0121 | 0.0152 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0056 | 0.0469 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0056 | 0.0469 | 0.0351 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0056 | 0.0469 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0404 | 0.0505 |
Echinococcus multilocularis | geminin | 0.0165 | 0.2692 | 0.2602 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0056 | 0.0469 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0282 | 0.0353 |
Echinococcus granulosus | geminin | 0.0165 | 0.2692 | 0.2456 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.7994 | 1 |
Brugia malayi | Subtilase family protein | 0.0267 | 0.476 | 1 |
Loa Loa (eye worm) | subtilase | 0.0267 | 0.476 | 0.5955 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.7994 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0056 | 0.0469 | 0.0351 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0056 | 0.0469 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0048 | 0.0312 | 0.0193 |
Loa Loa (eye worm) | FKBP5 protein | 0.0056 | 0.0469 | 0.0586 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0056 | 0.0469 | 0.0161 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0055 | 0.0452 | 0.0144 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0056 | 0.0469 | 0.0161 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0056 | 0.0469 | 0.0149 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0525 | 1 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.0452 | 0.0314 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0056 | 0.0469 | 0.0586 |
Echinococcus multilocularis | Peptidase S8 S53, subtilisin kexin sedolisin | 0.01 | 0.1365 | 0.1259 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.0452 | 0.0335 |
Trichomonas vaginalis | immunophilin, putative | 0.0056 | 0.0469 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0056 | 0.0469 | 0.0149 |
Schistosoma mansoni | tripeptidyl-peptidase II (S08 family) | 0.0267 | 0.476 | 1 |
Echinococcus granulosus | calpain A | 0.0055 | 0.0452 | 0.0144 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
PFA (functional) | 0 mg kg-1 | Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a dose of 10 (mg/kg); Activity between positive and negative control groups | ChEMBL. | 2562852 |
PFA (functional) | 0 mg kg-1 | Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a dose of 3.16 (mg/kg); Activity between positive and negative control groups | ChEMBL. | 2562852 |
PFA (functional) | 0 mg kg-1 | Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a dose of 1.0 (mg/kg); not significantly different from negative control group | ChEMBL. | 2562852 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.