Detailed information for compound 1875216

Basic information

Technical information
  • TDR Targets ID: 1875216
  • Name: BAS 01810090
  • MW: 315.324 | Formula: C16H17N3O4
  • H donors: 1 H acceptors: 2 LogP: 1.68 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)cc(c1/C=N/NC(=O)c1ccncc1)OC
  • InChi: 1S/C16H17N3O4/c1-21-12-8-14(22-2)13(15(9-12)23-3)10-18-19-16(20)11-4-6-17-7-5-11/h4-10H,1-3H3,(H,19,20)/b18-10+
  • InChiKey: BCQROTLTENFYGQ-VCHYOVAHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Isonicotinic acid (2,4,6-trimethoxy-benzylidene)-hydrazide
  • MLS001207970
  • N-[(2,4,6-trimethoxyphenyl)methylideneamino]pyridine-4-carboxamide
  • N-[(2,4,6-trimethoxyphenyl)methyleneamino]pyridine-4-carboxamide
  • N-[(2,4,6-trimethoxyphenyl)methyleneamino]-4-pyridinecarboxamide
  • N-[(2,4,6-trimethoxybenzylidene)amino]isonicotinamide
  • SMR000516996
  • ST073407

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0195 0.0426
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0318 0.029
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0356 0.0789
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.109 0.2106
Brugia malayi jmjC domain containing protein 0.0115 0.2122 0.4772
Schistosoma mansoni hypothetical protein 0.0205 0.398 0.3976
Loa Loa (eye worm) hypothetical protein 0.0021 0.0168 0.0371
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2096 0.5419
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0227 0.4443 1
Schistosoma mansoni ap endonuclease 0.0023 0.0195 0.0189
Onchocerca volvulus Alhambra homolog 0.0035 0.0455 0.077
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1235 0.2775
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0191 0.3703 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0455 0.0612
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0191 0.3703 1
Onchocerca volvulus 0.0035 0.0444 0.0708
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2096 0.5419
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0227 0.4443 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2096 0.4475
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.065 0.0644
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0455 0.1018
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2096 0.2096
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.065 0.1458
Brugia malayi hypothetical protein 0.003 0.0356 0.0795
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0227 0.4443 0.4443
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2096 0.5419
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2096 0.5419
Loa Loa (eye worm) hypothetical protein 0.0035 0.0455 0.1018
Schistosoma mansoni hypothetical protein 0.0205 0.398 0.3976
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0195 0.0432
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0318 0.029
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0227 0.4443 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0356 0.0789
Loa Loa (eye worm) hypothetical protein 0.0029 0.0318 0.071
Schistosoma mansoni hypothetical protein 0.0494 1 1
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0227 0.4443 1
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.065 0.065
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0227 0.4443 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2096 0.2096
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0318 0.071
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0318 0.0648
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0195 0.0432
Giardia lamblia PHD finger protein 15 0.0035 0.0455 0.1368
Chlamydia trachomatis transcriptional repressor NrdR 0.0036 0.0463 0.069
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0318 0.0648
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0356 0.0379
Echinococcus multilocularis peregrin 0.0035 0.0455 0.0455
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2096 0.5419
Loa Loa (eye worm) hypothetical protein 0.0029 0.0318 0.071
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2096 0.2091
Schistosoma mansoni cpg binding protein 0.0035 0.0444 0.0438
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0318 0.0491
Echinococcus multilocularis cpg binding protein 0.0037 0.0485 0.0485
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2096 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0168 0.0371
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0191 0.3703 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2096 0.4475
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0191 0.3703 1
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0742 0.0742
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0191 0.3703 1
Schistosoma mansoni cpg binding protein 0.0037 0.0485 0.0479
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1629 0.1623
Echinococcus granulosus geminin 0.0205 0.398 0.398
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2096 1
Echinococcus granulosus cpg binding protein 0.0037 0.0485 0.0485
Brugia malayi jmjC domain containing protein 0.0045 0.065 0.1458
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0609 0.0609
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0742 0.0742
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0318 0.0648
Schistosoma mansoni cpg binding protein 0.0037 0.0485 0.0479
Loa Loa (eye worm) hypothetical protein 0.0021 0.0168 0.0371
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0195 0.0195
Schistosoma mansoni ap endonuclease 0.0023 0.0195 0.0189
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0227 0.4443 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1253 0.1247
Schistosoma mansoni kinase 0.0058 0.0929 0.0923
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0036 0.0463 0.0897
Brugia malayi PHD-finger family protein 0.0035 0.0455 0.1018
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2096 0.5419
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0318 0.071
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0168 0.0364
Brugia malayi hypothetical protein 0.002 0.0131 0.0289
Loa Loa (eye worm) hypothetical protein 0.006 0.0978 0.2197
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0356 0.0379
Echinococcus multilocularis geminin 0.0205 0.398 0.398
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0227 0.4443 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0356 0.0789
Schistosoma mansoni hypothetical protein 0.0035 0.0455 0.0449
Loa Loa (eye worm) hypothetical protein 0.0029 0.0318 0.071
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0021 0.0168 0.0371
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0444 0.0993
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2096 0.4714
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0318 0.0426
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0168 0.0364
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0455 0.0455
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0463 0.0427
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0195 0.0078
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0168 0.0068
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2096 0.4714
Echinococcus granulosus peregrin 0.0035 0.0455 0.0455
Mycobacterium ulcerans hypothetical protein 0.0029 0.0318 0.0426
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2096 0.4475
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0182 0.0404
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0227 0.4443 0.444
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0318 0.0426
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0069 0.1154 0.2838
Mycobacterium ulcerans transcriptional regulator NrdR 0.0036 0.0463 0.0835
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0897 0.2002
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0006 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.065 0.0644
Brugia malayi Bromodomain containing protein 0.0035 0.0455 0.1018
Loa Loa (eye worm) hypothetical protein 0.003 0.0356 0.0795
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0227 0.4443 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0455 0.1012
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2122 0.2122
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0227 0.4443 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0356 0.0379
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0195 0.0145
Leishmania major hypothetical protein, conserved 0.003 0.0356 0.0379
Trypanosoma brucei polo-like protein kinase 0.0114 0.2096 0.4475
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0318 0.0426
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0897 0.2002
Brugia malayi CXXC zinc finger family protein 0.0035 0.0444 0.0993
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0141 0.0135
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0318 0.0426
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0455 0.0449
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0059 0.0944 0.1762
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0006 0.0006
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2122 0.2122
Plasmodium falciparum phd finger protein, putative 0.0035 0.0455 0.1012
Giardia lamblia Kinase, PLK 0.0114 0.2096 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0318 0.0426
Loa Loa (eye worm) hypothetical protein 0.0021 0.0168 0.0371
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0318 0.0491
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0318 0.0426
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0195 0.0426
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0227 0.4443 0.4443
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0318 0.029
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0318 0.071
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2096 0.5419
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0356 0.0379
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0195 0.0195
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0227 0.4443 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0318 0.0426
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0455 0.0612

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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