Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4303 | 0.4303 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 1 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0052 | 0.3446 | 0.3322 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.4704 | 0.4704 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0031 | 0.0306 | 0.0123 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0052 | 0.3472 | 0.3472 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Onchocerca volvulus | 0.0052 | 0.3472 | 0.004 | |
Brugia malayi | Hexokinase family protein | 0.0096 | 1 | 1 |
Onchocerca volvulus | 0.0058 | 0.4303 | 0.1308 | |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 0.3446 | 0.3322 |
Onchocerca volvulus | 0.0052 | 0.3472 | 0.004 | |
Onchocerca volvulus | 0.0052 | 0.3472 | 0.004 | |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.3446 | 0.3317 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3446 | 0.3446 |
Onchocerca volvulus | 0.006 | 0.4704 | 0.1919 | |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.3472 | 0.3344 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3472 | 0.3472 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0096 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Brugia malayi | Muscle positioning protein 4 | 0.0058 | 0.4303 | 0.4196 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.4704 | 0.4604 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0306 | 0.0306 |
Onchocerca volvulus | 0.0052 | 0.3472 | 0.004 | |
Schistosoma mansoni | hexokinase | 0.0096 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 1 | 0.5 |
Brugia malayi | SEA domain containing protein | 0.0052 | 0.3472 | 0.3349 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.006 | 0.4704 | 0.1919 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0306 | 0.0306 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0052 | 0.3446 | 0.3446 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5481 | 0.5481 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.003 | 0.0185 | 0.0185 |
Onchocerca volvulus | 0.0096 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 29.8 % | Antidiabetic activity in glucose-treated C57BL/J6 db/db mouse assessed as reduction of glucose AUC at 50 mg/kg, po preincubated for 30 mins followed by glucose challenge measured after 30 to 180 mins by oral glucose tolerance test relative to control | ChEMBL. | 24588963 |
EC50 (binding) | = 0.095 uM | Activation of recombinant human pancreatic glucokinase using 10 mM glucose by spectrophotometry | ChEMBL. | 24588963 |
S50 (binding) | = 2.01 mM | Activity of recombinant human pancreatic glucokinase assessed as glucose half-maximal saturation concentration | ChEMBL. | 24588963 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.