Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidine phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | thymidine phosphorylase | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Mycobacterium ulcerans | thymidine phosphorylase | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Echinococcus multilocularis | thymidine phosphorylase | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0022 | 0.0011 | 0.087 |
Echinococcus granulosus | bloom syndrome protein | 0.0044 | 0.03 | 0.0187 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0216 | 0.2615 | 0.5 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0044 | 0.03 | 0.0187 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.2095 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0044 | 0.03 | 0.0171 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0131 | 0.0626 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0044 | 0.03 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.0044 | 0.03 | 0.086 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0131 | 0.4373 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0044 | 0.03 | 0.0522 |
Entamoeba histolytica | recQ family helicase, putative | 0.0044 | 0.03 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0044 | 0.03 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0413 | 0.0869 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0413 | 0.1195 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0131 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0044 | 0.03 | 0.5 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.0765 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0218 | 0.2639 | 0.7825 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0044 | 0.03 | 0.0522 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0413 | 0.0869 |
Onchocerca volvulus | 0.0056 | 0.0457 | 0.112 | |
Schistosoma mansoni | DNA helicase recq5 | 0.0044 | 0.03 | 0.1433 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0011 | 0.00000000072304 |
Entamoeba histolytica | recQ family DNA helicase | 0.0022 | 0.0011 | 0.0381 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0044 | 0.03 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0131 | 0.0626 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.2095 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0272 | 0.337 | 0.3292 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0191 | 0.0184 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0131 | 0.0626 |
Echinococcus multilocularis | bloom syndrome protein | 0.0044 | 0.03 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0131 | 0.0357 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0457 | 0.2183 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0131 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.337 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0044 | 0.03 | 0.0187 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0457 | 0.2183 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0044 | 0.03 | 0.086 |
Brugia malayi | Pre-SET motif family protein | 0.0218 | 0.2639 | 0.7745 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0191 | 0.091 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0457 | 0.1007 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0044 | 0.03 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0413 | 0.1195 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0044 | 0.03 | 0.0171 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.0765 | 1 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0044 | 0.03 | 0.5 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0022 | 0.0011 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.03 | 0.086 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0022 | 0.0011 | 0.0381 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0044 | 0.03 | 0.0522 |
Brugia malayi | hypothetical protein | 0.0272 | 0.337 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0044 | 0.03 | 0.1433 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0044 | 0.03 | 1 |
Echinococcus multilocularis | geminin | 0.0177 | 0.2095 | 0.199 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0044 | 0.03 | 0.5 |
Echinococcus granulosus | geminin | 0.0177 | 0.2095 | 0.2003 |
Trichomonas vaginalis | set domain proteins, putative | 0.0248 | 0.3044 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0191 | 0.0534 |
Echinococcus multilocularis | thymidine phosphorylase | 0.0765 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0131 | 0.0626 |
Onchocerca volvulus | 0.0248 | 0.3044 | 1 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0272 | 0.337 | 0.3282 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0022 | 0.0011 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.699 | Inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli assessed as conversion of thymidine to thymine after 4 to 20 mins by spectrophotometric analysis | ChEMBL. | 24686016 |
IC50 (binding) | = 19.98 uM | Inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli assessed as conversion of thymidine to thymine after 4 to 20 mins by spectrophotometric analysis | ChEMBL. | 24686016 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.