Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 10 | Starlite/ChEMBL | References |
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 5 | Starlite/ChEMBL | References |
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 8 | Starlite/ChEMBL | References |
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 9 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | proteasome subunit alpha type-5, putative | proteasome (prosome, macropain) subunit, beta type, 5 | 160 aa | 148 aa | 23.0 % |
Toxoplasma gondii | proteasome subunit beta type 1, putative | proteasome (prosome, macropain) subunit, beta type, 8 | 272 aa | 251 aa | 23.1 % |
Plasmodium falciparum | proteasome subunit beta type-5 | proteasome (prosome, macropain) subunit, beta type, 9 | 219 aa | 199 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein arginine n-methyltransferase | 0.0844 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0183 | 0.0487 | 0.5 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0183 | 0.0487 | 0.5 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.0844 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0183 | 0.0487 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain | 0.0183 | 0.0487 | 0.0487 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0183 | 0.0487 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0183 | 0.0487 | 0.5 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.0844 | 1 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0183 | 0.0487 | 0.0487 |
Mycobacterium ulcerans | proteasome PrcB | 0.0183 | 0.0487 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0183 | 0.0487 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0183 | 0.0487 | 0.5 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0183 | 0.0487 | 0.5 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0183 | 0.0487 | 0.0487 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0183 | 0.0487 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0183 | 0.0487 | 0.5 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.0844 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0183 | 0.0487 | 0.5 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0183 | 0.0487 | 0.0487 |
Loa Loa (eye worm) | Carm1-pending protein | 0.0844 | 1 | 1 |
Onchocerca volvulus | 0.0768 | 0.8908 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.7 nM | Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometry | ChEMBL. | 25006746 |
IC50 (binding) | = 450 nM | Inhibition of beta5i subunit of immunoproteasome (unknown origin) by active-site ELISA | ChEMBL. | 24524217 |
IC50 (binding) | = 0.018 uM | Inhibition of proteasome subunit beta-5i in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry | ChEMBL. | 25006746 |
IC50 (binding) | = 0.34 uM | Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry | ChEMBL. | 25006746 |
IC50 (binding) | = 0.46 uM | Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry | ChEMBL. | 25006746 |
IC50 (binding) | = 0.59 uM | Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry | ChEMBL. | 25006746 |
IC50 (binding) | = 0.59 uM | Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry | ChEMBL. | 25006746 |
IC50 (binding) | > 1 uM | Inhibition of beta5 subunit of immunoproteasome (unknown origin) by active-site ELISA | ChEMBL. | 24524217 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.