Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.615 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.615 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.615 | 0.615 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.2937 | 0.4775 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.615 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.615 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.615 | 0.615 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.615 | 0.615 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.615 | 0.615 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.2937 | 0.2937 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.