Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fucosidase, alpha-L- 1, tissue | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Schistosoma mansoni | alpha-l-fucosidase | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Brugia malayi | Alpha-L-fucosidase family protein | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Schistosoma japonicum | ko:K01206 alpha-L-fucosidase [EC3.2.1.51], putative | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Loa Loa (eye worm) | alpha-L-fucosidase | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Mycobacterium ulcerans | alpha-L-fucosidase | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0517 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0246 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0246 | 0 | 0.5 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0517 | 1 | 0.5 |
Onchocerca volvulus | 0.0246 | 0 | 0.5 | |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0313 | 0.2452 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0246 | 0 | 0.5 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0246 | 0 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0246 | 0 | 0.5 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0313 | 0.2452 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0246 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0246 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0246 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0246 | 0 | 0.5 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0246 | 0 | 0.5 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0313 | 0.2452 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0246 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0246 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0246 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis | ChEMBL. | 9873733 |
IC50 (binding) | = 20 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis | ChEMBL. | 9873733 |
IC50 (binding) | = 40 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney | ChEMBL. | 9873733 |
IC50 (binding) | = 40 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney | ChEMBL. | 9873733 |
IC50 (binding) | = 56 nM | Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1 | ChEMBL. | 9873733 |
IC50 (binding) | = 56 nM | Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1 | ChEMBL. | 9873733 |
Ki (binding) | = 19 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis | ChEMBL. | 9873733 |
Ki (binding) | = 19 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis | ChEMBL. | 9873733 |
Ki (binding) | = 30 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney | ChEMBL. | 9873733 |
Ki (binding) | = 30 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney | ChEMBL. | 9873733 |
Ki (binding) | = 47 nM | Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1 | ChEMBL. | 9873733 |
Ki (binding) | = 47 nM | Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1 | ChEMBL. | 9873733 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.