Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0431 | 1 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.026 | 0.4825 | 0.4283 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0133 | 0.0949 | 0.0949 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0431 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0133 | 0.0949 | 0.0949 |
Echinococcus granulosus | proteasome prosome macropain | 0.0431 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0431 | 1 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0431 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0431 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0431 | 1 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.026 | 0.4825 | 0.4283 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0431 | 1 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0431 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0431 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0431 | 1 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.026 | 0.4825 | 0.4283 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.026 | 0.4825 | 0.4283 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0431 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0431 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0133 | 0.0949 | 0.0949 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0431 | 1 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.026 | 0.4825 | 0.4283 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0431 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0431 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0431 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 20 mg kg-1 | Antidepressant activity in ip dosed CD1 mouse assessed as inhibition of tetrabenazine methanesulfonate-induced reserpine like behavior administered 30 mins before tetrabenazine methanesulfonate challenge measured after 30 mins | ChEMBL. | 533882 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.