Detailed information for compound 1897339

Basic information

Technical information
  • TDR Targets ID: 1897339
  • Name: 2-(dimethylcarbamothioyldisulfanyl)benzoic ac id
  • MW: 273.395 | Formula: C10H11NO2S3
  • H donors: 1 H acceptors: 2 LogP: 2.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(N(C)C)SSc1ccccc1C(=O)O
  • InChi: 1S/C10H11NO2S3/c1-11(2)10(14)16-15-8-6-4-3-5-7(8)9(12)13/h3-6H,1-2H3,(H,12,13)
  • InChiKey: ZBZPMTRBQYUUJE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(dimethylamino-thioxomethyl)disulfanylbenzoic acid
  • 2-(dimethylthiocarbamoyldisulfanyl)benzoic acid
  • 62911-27-7
  • BRN 2130160
  • Carbamo(dithioperoxo)thioic acid, dimethyl-, 2-carboxyphenyl ester
  • Dimethylcarbamo(dithioperoxo)thioic acid 2-carboxyphenyl ester
  • o-Carboxyphenyl N,N-dimethyltrithiopercarbamate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Schistosoma mansoni cathepsin F (C01 family) 0.0122 0.459 0.459
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.8722 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trypanosoma cruzi cysteine proteinase, putative 0.0095 0.2661 0.2661
Echinococcus granulosus cathepsin L 0.0095 0.2661 0.2645
Schistosoma mansoni biogenic amine receptor 0.0058 0.0022 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.018 0.8722 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Brugia malayi Cathepsin L-like precursor 0.018 0.8722 0.8722
Entamoeba histolytica cysteine proteinase, putative 0.0122 0.459 0.3182
Onchocerca volvulus 0.018 0.8722 1
Brugia malayi Cathepsin L-like precursor 0.018 0.8722 0.8722
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Brugia malayi putative neuropeptide receptor NPR1 0.0058 0.0022 0.0022
Brugia malayi neuropeptide F receptor 0.0058 0.0022 0.0022
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) papain family cysteine protease containing protein 0.018 0.8722 0.8722
Echinococcus granulosus cathepsin l1 0.018 0.8722 0.8719
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Schistosoma mansoni amine GPCR 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Onchocerca volvulus Cathepsin F homolog 0.018 0.8722 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0058 0.0022 0.0022
Leishmania major cathepsin L-like protease 0.018 0.8722 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0058 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.018 0.8722 1
Trypanosoma cruzi cysteine peptidase, putative 0.018 0.8722 0.8722
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.018 0.8722 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.018 0.8722 0.8719
Trypanosoma cruzi cruzipain precursor, putative 0.018 0.8722 0.8722
Onchocerca volvulus 0.018 0.8722 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0058 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.018 0.8722 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.2661 0.0879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.2661 0.0879
Schistosoma mansoni amine GPCR 0.0058 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0022 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) ctsf protein 0.018 0.8722 0.8722
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0058 0.0022 0.0022
Schistosoma mansoni opsin-like receptor 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Onchocerca volvulus 0.018 0.8722 1
Brugia malayi G protein-coupled receptor 0.0058 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.018 0.8722 1
Onchocerca volvulus 0.018 0.8722 1
Brugia malayi Dopamine receptor protein 2 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0087 0.2077 0.2077
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.018 0.8722 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.2661 0.2661
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.2661 0.2661
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Schistosoma mansoni neuropeptide receptor 0.0058 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0022 0.0022
Brugia malayi G-protein coupled receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0087 0.2077 0.2077
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0022 0.0022
Brugia malayi Serotonin receptor 0.0058 0.0022 0.0022
Trypanosoma cruzi cysteine peptidase, putative 0.018 0.8722 0.8722
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.018 0.8722 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0198 1 1
Brugia malayi sulfakinin receptor protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.018 0.8722 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0058 0.0022 0.0022
Leishmania major cathepsin L-like protease 0.018 0.8722 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0022 0.0022
Onchocerca volvulus Cathepsin L homolog 0.018 0.8722 1
Brugia malayi RE15519p 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Brugia malayi hypothetical protein 0.0058 0.0022 0.0022
Onchocerca volvulus 0.018 0.8722 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.018 0.8722 0.8719
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.018 0.8722 0.8722
Loa Loa (eye worm) hypothetical protein 0.0198 1 1
Schistosoma mansoni hypothetical protein 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.8722 1
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.0022 0.0022
Trypanosoma cruzi cysteine proteinase, putative 0.0095 0.2661 0.2661
Leishmania major cathepsin L-like protease 0.018 0.8722 1
Brugia malayi hypothetical protein 0.0058 0.0022 0.0022
Echinococcus granulosus cathepsin l1 0.0122 0.459 0.4577
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0122 0.459 0.459
Schistosoma mansoni biogenic amine receptor 0.0058 0.0022 0.0022
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.2661 0.2661
Brugia malayi Melatonin receptor type 1A 0.0058 0.0022 0.0022
Plasmodium falciparum cysteine proteinase falcipain 2a 0.018 0.8722 1
Brugia malayi putative neuropeptide receptor 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Brugia malayi neuropeptide F receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Brugia malayi Cathepsin L-like cysteine proteinase 0.0122 0.459 0.459
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Echinococcus multilocularis cysteine protease 0.018 0.8722 0.8719
Brugia malayi hypothetical protein 0.0058 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.018 0.8722 1
Schistosoma mansoni hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.8722 1
Entamoeba histolytica cysteine protease, putative 0.018 0.8722 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0022 0.0022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 1 1
Brugia malayi cathepsin L-like precursor 0.0122 0.459 0.459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.018 0.8722 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.8722 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0058 0.0022 0.0022
Onchocerca volvulus 0.018 0.8722 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.018 0.8722 1
Brugia malayi hypothetical protein 0.0058 0.0022 0.0022
Plasmodium falciparum cysteine proteinase falcipain 3 0.018 0.8722 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Plasmodium vivax vivapain-2 0.018 0.8722 1
Schistosoma mansoni amine GPCR 0.0058 0.0022 0.0022
Brugia malayi larval opioid receptor 0.0058 0.0022 0.0022
Giardia lamblia Cathepsin B precursor 0.0087 0.2077 0.5
Leishmania major cathepsin L-like protease 0.018 0.8722 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Brugia malayi Dopamine receptor 0.0058 0.0022 0.0022
Brugia malayi hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Plasmodium falciparum cysteine proteinase falcipain 2b 0.018 0.8722 1
Brugia malayi hypothetical protein 0.0058 0.0022 0.0022
Echinococcus multilocularis cathepsin b 0.0198 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Brugia malayi hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Brugia malayi G protein-coupled receptor F59B2.13 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 1 1
Plasmodium vivax vivapain-1 0.0095 0.2661 0.3051
Echinococcus multilocularis cathepsin L cysteine protease 0.018 0.8722 0.8719
Schistosoma mansoni neuropeptide receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0058 0.0022 0.0022
Leishmania major cathepsin L-like protease 0.018 0.8722 1
Plasmodium vivax vivapain-3 0.0095 0.2661 0.3051
Loa Loa (eye worm) TYRA-2 protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Echinococcus granulosus cathepsin b 0.0198 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0058 0.0022 0.0022
Brugia malayi G-protein coupled receptor 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0122 0.459 0.3781
Giardia lamblia Cathepsin B precursor 0.0087 0.2077 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.0022 0.0022
Leishmania major cathepsin L-like protease 0.018 0.8722 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.8722 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Brugia malayi ORL1-like opioid receptor 0.0058 0.0022 0.0022
Echinococcus multilocularis cathepsin l cysteine peptidase 0.018 0.8722 0.8719
Onchocerca volvulus Cathepsin L homolog 0.018 0.8722 1
Schistosoma mansoni opsin-like receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) fibroinase 0.018 0.8722 0.8722
Leishmania major cathepsin L-like protease 0.018 0.8722 1
Schistosoma mansoni neuropeptide receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0058 0.0022 0.0022
Brugia malayi Serotonin receptor 0.0058 0.0022 0.0022
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.2661 0.2661
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Brugia malayi AKH receptor 0.0058 0.0022 0.0022
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.2661 0.2661
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trypanosoma cruzi cysteine peptidase, putative 0.018 0.8722 0.8722
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.8722 1
Brugia malayi follicle stimulating hormone receptor 0.0058 0.0022 0.0022
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0058 0.0022 0.0022
Brugia malayi hypothetical protein 0.0058 0.0022 0.0022
Brugia malayi hypothetical protein 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.8722 1
Echinococcus granulosus cysteine protease 0.0095 0.2661 0.2645
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Schistosoma mansoni myosin xvIII 0.0058 0.0022 0.0022
Loa Loa (eye worm) cysteine protease 0.018 0.8722 0.8722
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0122 0.459 0.459
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.8722 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0022 0.0022
Brugia malayi Cathepsin L-like precursor 0.018 0.8722 0.8722
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.2661 0.0879
Onchocerca volvulus 0.018 0.8722 1
Schistosoma mansoni amine GPCR 0.0058 0.0022 0.0022
Toxoplasma gondii cathepsin CPL 0.018 0.8722 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Leishmania major cysteine peptidase A (CPA) 0.018 0.8722 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0058 0.0022 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.018 0.8722 0.8719
Brugia malayi Papain family cysteine protease containing protein 0.018 0.8722 0.8722
Entamoeba histolytica cysteine proteinase, putative 0.018 0.8722 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0122 0.459 0.459
Loa Loa (eye worm) hypothetical protein 0.0122 0.459 0.459
Brugia malayi Cathepsin L-like precursor 0.018 0.8722 0.8722
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0058 0.0022 0.0022
Trypanosoma cruzi cysteine protease, putative 0.0095 0.2661 0.2661
Echinococcus multilocularis cathepsin b 0.0198 1 1
Echinococcus granulosus cathepsin b 0.0198 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Giardia lamblia Cathepsin B precursor 0.0087 0.2077 0.5
Schistosoma mansoni biogenic amine receptor 0.0058 0.0022 0.0022
Echinococcus multilocularis cathepsin l cysteine peptidase 0.018 0.8722 0.8719
Brugia malayi GnHR receptor homolog 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.8722 1
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.0022 0.0022
Echinococcus granulosus cathepsin L cysteine protease 0.0095 0.2661 0.2645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Brugia malayi Dopamine receptor protein 1 0.0058 0.0022 0.0022
Leishmania major cathepsin L-like protease 0.018 0.8722 1
Loa Loa (eye worm) cathepsin B 0.0087 0.2077 0.2077
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.0022 0.0022
Echinococcus multilocularis cysteine protease 0.018 0.8722 0.8719
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Schistosoma mansoni histamine h1 receptor 0.0058 0.0022 0.0022
Schistosoma mansoni opsin-like receptor 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.018 0.8722 1
Brugia malayi Cathepsin L-like precursor 0.018 0.8722 0.8722
Schistosoma mansoni alpha-1 adrenergic receptor 0.0058 0.0022 0.0022
Brugia malayi Cathepsin L-like precursor 0.018 0.8722 0.8722
Plasmodium vivax unspecified product 0.0095 0.2661 0.3051
Schistosoma mansoni neuropeptide f receptor 76f 0.0058 0.0022 0.0022
Schistosoma mansoni cathepsin F (C01 family) 0.018 0.8722 0.8722
Brugia malayi Cathepsin L-like precursor 0.0122 0.459 0.459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0095 0.2661 0.2661
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.8722 1
Brugia malayi Cathepsin L-like precursor 0.0122 0.459 0.459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.018 0.8722 1
Echinococcus multilocularis cathepsin L 0.0095 0.2661 0.2645
Brugia malayi hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Schistosoma mansoni adenoreceptor 0.0058 0.0022 0.0022
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.2661 0.0879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0058 0.0022 0.0022
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0058 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0058 0.0022 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.0022 0.0022
Schistosoma mansoni amine GPCR 0.0058 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0022 0.0022
Plasmodium vivax vivapain-2 0.018 0.8722 1
Schistosoma mansoni neuropeptide receptor 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.018 0.8722 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0122 0.459 0.3781
Loa Loa (eye worm) hypothetical protein 0.0058 0.0022 0.0022
Onchocerca volvulus 0.0122 0.459 0.525
Schistosoma mansoni cathepsin F (C01 family) 0.018 0.8722 0.8722
Trypanosoma cruzi cysteine peptidase, putative 0.0095 0.2661 0.2661
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0058 0.0022 0.0022
Trypanosoma cruzi cysteine peptidase, putative 0.018 0.8722 0.8722
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0198 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.018 0.8722 0.8722

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 0.1 g/Kg Toxicity in ip dosed mouse ChEMBL. 330858

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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